THE INTENSITY OF LIPID PEROXIDATION PROCESSES IN WOMEN WITH PRIMARY VARICOSE VEINS OF THE PELVIC DEPENDING ON THE STAGE OF THE DISEASE

Cover Page
  • Authors: Kolesnikova, L.I.1,2, Semendyaev A.A.1,3, Stupin D.A.1, Darenskaya M.A.1, Grebenkina [.A.1, Natyaganova L.V.1, Danusevich I.N.1, Cherepanova M.A.4, Kolesnikov S.I.1,5
  • Affiliations:
    1. Scientific Centre for Family Health and Human Reproduction Problems
    2. Irkutsk State University
    3. Irkutsk State Medical University
    4. Maternity hospital № 25
    5. Lomonosov Moscow State University
  • Issue: Vol 73, No 4 (2018)
  • Pages: 229-235
  • Section: BIOCHEMISTRY: CURRENT ISSUES
  • URL: https://vestnikramn.spr-journal.ru/jour/article/view/1005
  • DOI: https://doi.org/10.15690/vramn1005

Abstract


Background: Information about involvement of general nonspecific reactions, in particular lipid peroxidation processes, in the progression of varicose veins of the pelvic (VVP) in women is still too scarce. Aims: To study the intensity of processes of lipid peroxidation and the activity of components of the antioxidant system in women with primary varicose veins of the pelvic at different stages of the disease. Materials and methods: 167 women of reproductive age were examined ― 137 with VVP and 30 made up a control group. All patients with VVP were divided into 3 groups depending on stages of the disease. Spectrophotometric and fluorometric methods of investigation were used. The study was conducted during 2012−2017. Results: It was revealed that the level of primary products of lipid peroxidation, diene conjugates, increased statistically significantly according to the stage of the disease by 1.25 times (in the 1st stage), 1.51 times (in the II stage) and 1.59 times (in the III stage) values. Changes in the content of final TBA-active products showed similar changes-an increase in the mean values for all stages of the disease relative to control (in 1.24, 1.17, and 1.77 times, respectively). Activity of glutathione peroxidase increased in stage 2 of VVP (1.19 times), with the maximum increase in stage III (1.42 times); activity of glutathione-S-transferase increased 1.18 times in the II stage of the disease. The concentration of GSH in the clinical groups was characterized by lower values with respect to the control (by 1.22 times in the 1st stage, in 1.64 times in the II stage), with the maximum decrease of this parameter in the III stage of VVP (3.67 times). The level of catalase activity increased in the I stage of VVP ― by 1.18 times and decreased in the III stage ― by 1.14 times with respect to the control. The activity of SOD showed similar changes with catalase ― in the form of increased activity at the 1st stage (1.35 times higher) and decreased values for II (1.35 times lower) and III (1.65 times lower) for the stages of VVP to the values of control. Conclusions: At progression of primary VVP in women (from the initial stage to the 3rd stage of the disease), there is an increase in imbalance in the lipid peroxidation − antioxidant defense system. Moreover, if the compensatory increase in activity of antioxidant enzymes is registered at stage 1 of the disease, then the most of the antioxidant defense factors decreases as relative to control values, and the initial stages of the disease.


Lyubov’ I. Kolesnikova,

Scientific Centre for Family Health and Human Reproduction Problems; Irkutsk State University

Email: iphr@sbamsr.irk.ru
ORCID iD: 0000-0003-3354-2992

Russian Federation

MD, PhD, Professor.

Irkutsk.

SPIN-код: 1584-0281

Andrey A. Semendyaev

Scientific Centre for Family Health and Human Reproduction Problems; Irkutsk State Medical University

Email: ismupriem@mail.ru
ORCID iD: 0000-0002-4107-6285

Russian Federation

MD, PhD, Professor.

Irkutsk.

SPIN-код: 3598-8817

Dmitriy A. Stupin

Scientific Centre for Family Health and Human Reproduction Problems

Email: stupindima@rambler.ru
ORCID iD: 0000-0002-0687-4804

Russian Federation

MD.

Irkutsk.

SPIN-код: 6459-1703

 

Marina A. Darenskaya

Scientific Centre for Family Health and Human Reproduction Problems

Author for correspondence.
Email: marina_darenskaya@inbox.ru
ORCID iD: 0000-0003-3255-2013

Russian Federation

PhD.

16 Timiryazeva street, 664003 Irkutsk, тел.: +7 (3952) 20-73-67.

SPIN-код: 3327-4213

[Lyudmila A. Grebenkina

Scientific Centre for Family Health and Human Reproduction Problems

Email: greblud@mail.ru
ORCID iD: 0000-0002-1263-5527

Russian Federation

PhD.

Irkutsk.

SPIN-код: 6194-5785

 

Larisa V. Natyaganova

Scientific Centre for Family Health and Human Reproduction Problems

Email: irklara@yandex.ru
ORCID iD: 0000-0002-9315-2307

Russian Federation

PhD.

Irkutsk.

SPIN-код: 5956-1754

Irina N. Danusevich

Scientific Centre for Family Health and Human Reproduction Problems

Email: irinaemails@gmail.com
ORCID iD: 0000-0002-8862-5771

Russian Federation

MD, PhD.

Irkutsk.

SPIN-код: 6289-3358

 

Mariya A. Cherepanova

Maternity hospital № 25

Email: batontchik@yandex.ru
ORCID iD: 0000-0002-6891-3338

Russian Federation

MD, PhD.

Moscow.

SPIN-код: 7850-1633

 

Sergey I. Kolesnikov

Scientific Centre for Family Health and Human Reproduction Problems; Lomonosov Moscow State University

Email: iphr@sbamsr.irk.ru
ORCID iD: 0000-0003-2124-6328

Russian Federation

MD, PhD, Professor.

Irkutsk, Moscow.

SPIN-код: 1752-6695

 

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