Correlation Between Emotional-Affective Disorders and Gut Microbiota Composition in Patients with Parkinson’s Disease

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Abstract

Background: Despite the efforts of scientific community the data available on the correlation between emotional-affective symptoms of Parkinson’s disease and changes in microbiome is still scarce. Deeper studies of nonmotor symptoms evident in premotor stages of the disease and the reciprocal influence of microbiota may help to understand the etiology and pathogenesis of PD neurodegeneration better.

The aim of the study was to discover the relations between emotional-affective disorders prevalent in PD population and changes in gut microbiota composition.

Мethods: 51 patient diagnosed with PD participated in the study. Every participant’s emotional-affective state was examined using Beck’s Depression Inventory (BDI) and Hospital Anxiety and Depression Scale (HADS). Taxonomic richness of microbiome was studied using 16S ribosomal RNA gene sequencing, bioinformatics, and statistical analysis.

Results: Anxiety and depression are prevalent affective disorders in patients with PD. In our study, most of the subjects demonstrated certain anxiety and depression. Taxonomic diversity of gut microbiota in BP was increasing with the increase in anxiety levels, reaching the maximum in the group with subclinical anxiety, and decreasing in the group with clinically significant anxiety disorder. At the species level, patients with clinically significant anxiety had higher abundance of Clostridium clariflavum compared to the anxiety-free patients. Patients with moderate depression were characterized by the higher prevalence of Christensenella minuta, Clostridium disporicum, and Oscillibacter valericigenes compared to subjects without depression or with mild depression.

Conclusion: The data we received in our study allow better understanding of PD pathogenesis.

About the authors

V. M. Alifirova

Department of Neurology and Neurosurgery, Siberian State Medical University

Author for correspondence.
Email: v_alifirova@mail.ru
ORCID iD: 0000-0002-4140-3223

Tomsk, Russian Federation

Russian Federation

N. G. Zhukova

Department of Neurology and Neurosurgery, Siberian State Medical University

Email: znatali@yandex.ru
ORCID iD: 0000-0001-6547-6622

Tomsk, Russian Federation

Russian Federation

I. A. Zhukova

Department of Neurology and Neurosurgery, Siberian State Medical University

Email: irzhukova@inbox.ru
ORCID iD: 0000-0001-5679-1698

Tomsk, Russian Federation

Russian Federation

Yu. S. Mironova

Department of Neurology and Neurosurgery, Siberian State Medical University

Email: mir.yuli@mail.ru
ORCID iD: 0000-0002-3834-5923

Tomsk, Russian Federation

Russian Federation

V. A. Petrov

Central Research Laboratory, Siberian State Medical University

Email: vyacheslav.a.petrov@mail.ru
ORCID iD: 0000-0002-5205-9739

младший научный сотрудник Центральной научно-исследовательской лаборатории ФГБОУ ВО «Сибирский государственный медицинский университет» Минздрава России Адрес: 634001, Томск, Московский тракт, д. 2 г, стр. 18, тел.: +7 (3822) 90-11-01 доб. 16-35

Russian Federation

O. P. Izhboldina

Department of Neurology and Neurosurgery, Siberian State Medical University

Email: olga.izhboldina@inbox.ru
ORCID iD: 0000-0003-3705-9615
Tomsk, Russian Federation Russian Federation

M. A. Titova

Department of Neurology and Neurosurgery, Siberian State Medical University

Email: titovam82@list.ru
ORCID iD: 0000-0002-0080-3765

Tomsk, Russian Federation

Russian Federation

A. V. Latypova

Department of Neurology and Neurosurgery, Siberian State Medical University

Email: lina.lae@gmail.com
ORCID iD: 0000-0003-0676-3968

Tomsk, Russian Federation

Russian Federation

M. A. Nikitina

Department of Neurology and Neurosurgery, Siberian State Medical University

Email: nikitina_ma@mail.ru
ORCID iD: 0000-0002-2614-207X
Tomsk, Russian Federation Russian Federation

Y. B. Dorofeeva

Central Research Laboratory, Siberian State Medical University

Email: julia.dorofeeva25@gmail.com

Tomsk, Russian Federation

Russian Federation

I. V. Saltykova

Central Research Laboratory, Siberian State Medical University

Email: ira.salticova@mail.ru
ORCID iD: 0000-0002-0457-5392

Tomsk, Russian Federation

Russian Federation

A. V. Tyakht

Scientific Research Institute of Physical-Chemical Medicine

Email: at@niifhm.ru
ORCID iD: 0000-0002-7358-2537

Moscow, Russian Federation

Russian Federation

E. S. Kostryukova

Scientific Research Institute of Physical-Chemical Medicine

Email: el-es@yandex.ru
ORCID iD: 0000-0002-0457-6803

Moscow, Russian Federation

Russian Federation

A. E. Sazonov

Central Research Laboratory, Siberian State Medical University

Lomonosov Moscow State University

Email: sazonov_al@mail.ru

Tomsk, Russian Federation

Moscow, Russian Federation

Russian Federation

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