CONTRIBUTION OF NON-HLA GENES TO JUVENILE IDIOPATHIC ARTHRITIS SUSCEPTIBILITY

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Abstract

Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatologic disease in children. JIA is a group of disorders that share the clinical manifestation of chronic joint inflammation. The Human Leukocyte Antigen region (HLA) seems to be a major susceptibility locus for JIA that is estimated to account for 17% of familial segregation of the disease. Genome-wide association studies (GWAS), case-control studies and meta-analyses of the post-GWAS era revealed over 20 non-HLA loci conferring susceptibility to JIA. At least a half of those are shared between JIA and rheumatoid arthritis, an adult rheumatic disease, thereby suggesting for similarity of pathogenic mechanisms of both diseases. New findings also suggest for a likely role of epigenetic alterations in the pathogenesis of JIA that should be investigated in the future.

About the authors

K. V. Savost'yanov

Scientific Centre of Children Health, Moscow

Author for correspondence.
Email: 7443333@gmail.com
кандидат биологических наук, заведующий лабораторией молекулярной генетики и клеточной биологии Лабораторного отдела Научного центра здоровья детей Адрес: 119991, Москва, Ломоносовский пр-т, д. 2, стр. 1, тел.: +7 (495) 744-33-33 Russian Federation

E. I. Alexeeva

Scientific Centre of Children Health, Moscow
I.M. Sechenov First Moscow State Medical University

Email: alekatya@ya.ru
доктор медицинских наук, профессор, заведующая ревматологическим отделением Научного центра здоровья детей, декан педиатрического факультета Первого МГМУ им. И.М. Сеченова Адрес: 119991, Москва, Ломоносовский пр-т, д. 2, стр. 1 тел.: +7 (499) 134-02-97 Russian Federation

D. A. Chistiakov

Scientific Centre of Children Health, Moscow
N.I. Pirogov Russian National Research Medical University, Moscow

Email: dimitry.chistiakov@lycos.com
доктор биологических наук, профессор, главный научный сотрудник лабо- ратории молекулярной генетики и клеточной биологии Лабораторного отдела Научного центра здоровья детей, ведущий научный сотрудник РНИМУ им. Н.И. Пирогова Адрес: 117997, Москва, ул. Островитянова, д. 1, тел.: +7 (499) 134-09-19 Russian Federation

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