PREVENTION OF TUBERCULOSIS: CURRENT APPROACHES TO DEVELOPMENT OF VACCINES

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Abstract

This review is focused on recent advances in development of new vaccines for the prevention of tuberculosis. The main reasons for lack of BCG vaccine efficacy in different populations and geographic regions are presented. Design of new vaccines based on live modified strains of Mycobacterium bovis BCG, attenuated strains of Mycobacterium tuberculosis, recombinant proteins and viral vectors is considered in the specific examples. The usage of the heterologous «prime-boost» vaccination strategy against tuberculosis is discussed.

 

About the authors

M. A. Stukova

Research Institute of Influenza, Ministry of Health and Social Development, Saint Petersburg, Russian Federation

Author for correspondence.
Email: stukova@influenza.spb.ru
кандидат медицинских наук, ведущий научный сотрудник лаборатории молеку- лярной вирусологии и генной инженерии ФГБУ «Научно-исследовательский институт гриппа» МЗ РФ Адрес: 197376, Санкт-Петербург, ул. Проф. Попова, д. 15/17 Тел.: (812) 499-15-20 Russian Federation

N. V. Zabolotnykh

Saint-Petersburg Research Institute of Phthisiopulmonology, Ministry of Health and Social Development Saint Petersburg, Russian Federation

Email: zabol-natal@yandex.ru
доктор медицинских наук, ведущий научный сотрудник лаборатории экспери- ментального туберкулеза и новых медицинских технологий ФГБУ «Санкт-Петербургский научно-исследовательский институт фтизиопульмонологии» МЗ РФ Адрес: 191036, Санкт-Петербург, Лиговский пр-т, д. 2-4 Тел.: (812) 297-86-31 Russian Federation

T. I. Vinogradova

Saint-Petersburg Research Institute of Phthisiopulmonology, Ministry of Health and Social Development Saint Petersburg, Russian Federation

Email: vinogradova@spbniif.ru
доктор медицинских наук, профессор, ученый секретарь ФГБУ «Санкт- Петербургский научно-исследовательский институт фтизиопульмонологии» МЗ РФ Адрес: 191036, Санкт-Петербург, Лиговский пр-т, д. 2-4 Тел.: (812) 579-25-84 Russian Federation

V. Ya. Gergert

Central Institute for Tuberculosis, Russian Academy of Medical Science, Moscow, Russian Federation

Email: hergert@mail.ru
доктор медицинских наук, профессор, руководитель отдела иммунологии ФГБУ «Центральный научно-исследовательский институт туберкулеза» РАМН Адрес: 107564, Москва, ул. Яузская аллея, д. 2 Тел.: (499) 785-90-72 Russian Federation

A. S. Apt

Central Institute for Tuberculosis, Russian Academy of Medical Science, Moscow, Russian Federation

Email: stukova@influenza.spb.ru
доктор биологических наук, профессор, заведующий лабораторией иммуногенетики ФГБУ «Центральный научно-исследовательский институт туберкулеза» РАМН Адрес: 107564, Москва, ул. Яузская аллея, д. 2 Тел.: (499) 785-90-72 Russian Federation

V. V. Erokhin

Central Institute for Tuberculosis, Russian Academy of Medical Science, Moscow, Russian Federation

Email: inbi@inbi.ras.ru
доктор биологических наук, профессор, заведующий лабораторией стрессов микроорганизмов ФГБУ «Научно-исследовательский институт биохимии им. А.Н. Баха» РАН Адрес: 125284, Москва, Ленинский пр-т, д. 33 Тел.: (495) 954-40-47 Russian Federation

A. S. Kaprelyants

A.N. Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russian Federation

Email: cniit@ramn.ru
доктор медицинских наук, профессор, член-корреспондент РАМН, директор ФГБУ «Центральный научно-исследовательский институт туберкулеза» РАМН Адрес: 107564, Москва, ул. Яузская аллея, д. 2 Тел.: (499) 785-91-36 Russian Federation

P. K. Yablonskii

Saint-Petersburg Research Institute of Phthisiopulmonology, Ministry of Health and Social Development Saint Petersburg, Russian Federation
Saint Petersburg State University, Russian Federation

Email: spbniif_all@mail.ru
доктор медицинских наук, профессор, директор ФГБУ «Санкт-Петербургский научно-исследовательский институт фтизиопульмонологии» МЗ РФ, профессор медицинского факультета ФГБО ВПО «Санкт-Петербургский государственный университет» Адрес: 191036, Санкт-Петербург, Лиговский пр-т, д. 2-4 Тел.: (812) 579-25-54 Russian Federation

O. I. Kiselev

Research Institute of Influenza, Ministry of Health and Social Development, Saint Petersburg, Russian Federation

Email: office@influenza.spb.ru
академик РАМН, профессор, директор ФГБУ «Научно-исследовательский институт гриппа» МЗ РФ Адрес: 197376, Санкт-Петербург, ул. Проф. Попова, д. 15/17 Тел.: (812) 234-60-00 Russian Federation

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