ADAPTIVE PHENOMENON OF ISCHEMIC POSTCONDITIONING OF THE HEART. PERSPECTIVES OF CLINICAL USE

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Abstract

Analysis of experimental data indicates that aging, metabolic syndrome may be serious obstacle against realization of cardioprotective effect of postconditioning. The moderate hypercholesterolemia, postinfarction cardiosclerosis and cardiac hypertrophy do not abolish protective effect of postconditioning in experimental animals. The issue whether diabetes mellitus and arterial hypertension affect an efficacy of postconditioning is a subject of discussion. Clinical investigations testify on cardioprotective impact of postconditioning in patients with acute myocardial infarction and cardiosurgery patients. At the same time, it is remained unclear when after coronary artery occlusion postconditioning exhibits cardioprotective effect. It is remained unknown how do affect aging, diabetes mellitus, metabolic syndrome, arterial hypertension, myocardial hypertrophy, cardiac postinfarction remodeling and efficacy postconditioning in clinical praxis. It is required a further clinical investigations turning the development pharmacological approaches to prophylaxis of reperfusion injury of the heart.

About the authors

L. N. Maslov

Federal State Budgetary Institution «Research Institute for Cardiology» of Siberian Branch under the Russian Academy
of Medical Sciences, Tomsk, Russian Federation

Author for correspondence.
Email: maslov@cardio.tsu.ru

PhD, Professor, Head of the laboratory of experimental Cardiology «Research Institute of Cardiology» Siberian Branch of the Russian Academy of Medical Sciences
Address: 634012, Tomsk, Kiev St. 111; tel.: (3822) 26-21-74

Russian Federation

A. G. Mrochek

Republic Scientific-Practical Center “Cardiology”, Minsk, Belarus

Email: a.mrochek@mail.by

PhD, Professor, Academician of the National Academy of Sciences of Belarus, Director of Republican Scientific Practical Center «Сardiology» Address: 220036, Minsk, Rosa Luxemburg St. 110

Belarus

I. Khaliulin

University of Bristol, Bristol, UK

Email: I.Khaliulin@bristol.ac.uk

PhD, Research Worker Biochemistry Department University of Bristol
Address: University Walk, Bristol, BS8 1TD UK; tel.: +44 (0)117-331-21-20

United Kingdom

L. Hanuš

Institute for Drug Research, Faculty of Medicine, Hebrew University of Jerusalem, Israel

Email: lumirh@ekmd.huji.ac.il
Professor, Hebrew University’s School of Pharmacy
Address: Jerusalem, Israel, The Hebrew University of Jerusalem Israel

J.-M. Pei

Fourth Military Medical University, Xi'an, Shaanxi Province, China

Email: Jmpei8@fmmu.edu.cn

Professor, Department of Physiology, Fourth Military Medical University
Address: 710032, Shaanxi Province, China, West Changle Road, Xi’an

China

Y. Zhang

Hebei Medical University, Shijiazhuang, China

Email: zhyhenry@hotmail.com

Professor, Department of Physiology, Hebei Medical University
Address: Shijiazhuang 050017, China, 361, East Zhongshan Road

China

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