АДАПТИВНЫЙ ФЕНОМЕН ИШЕМИЧЕСКОГО ПОСТКОНДИЦИОНИРОВАНИЯ СЕРДЦА. ПЕРСПЕКТИВЫ КЛИНИЧЕСКОГО ПРИМЕНЕНИЯ

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Аннотация

Анализ экспериментальных данных свидетельствует о том, что старение и метаболический синдром могут быть серьезными препятствиями для реализации кардиопротекторного эффекта посткондиционирования. Умеренная гиперхолестеринемия, постинфарктный кардиосклероз и гипертрофия сердца не устраняют защитный эффект посткондиционирования у экспериментальных животных. Вопрос о том, влияют ли экспериментальный сахарный диабет и артериальная гипертензия на эффективность посткондиционирования, является предметом дискуссии. Клинические исследования свидетельствуют о кардиопротекторном действии посткондиционирования у больных острым инфарктом миокарда и кардиохирургических пациентов. Вместе с тем, остается неясным, в какие сроки после появления коронарной окклюзии посткондиционирование оказывает кардиопротекторный эффект. Также остается неизвестным, как влияют старение, сахарный диабет, метаболический синдром, артериальная гипертензия, гипертрофия миокарда, постинфарктное ремоделирование сердца на эффективность посткондиционирования в клинической практике. Требуются дальнейшие клинические исследования, направленные на разработку фармакологических подходов к профилактике реперфузионных повреждений сердца.

Об авторах

Л. Н. Маслов

НИИ кардиологии СО РАМН, Томск, Российская Федерация

Автор, ответственный за переписку.
Email: maslov@cardio.tsu.ru

PhD, Professor, Head of the laboratory of experimental Cardiology «Research Institute of Cardiology» Siberian Branch of the Russian Academy of Medical Sciences
Address: 634012, Tomsk, Kiev St. 111; tel.: (3822) 26-21-74

Россия

А. Г. Мрочек

Республиканский научно-практический центр «Кардиология», Минск, Республика Беларусь

Email: a.mrochek@mail.by

PhD, Professor, Academician of the National Academy of Sciences of Belarus, Director of Republican Scientific Practical Center «Сardiology» Address: 220036, Minsk, Rosa Luxemburg St. 110

Белоруссия

И. Г. Халиулин

Университет Бристоля, Великобритания

Email: I.Khaliulin@bristol.ac.uk

PhD, Research Worker Biochemistry Department University of Bristol
Address: University Walk, Bristol, BS8 1TD UK; tel.: +44 (0)117-331-21-20

Великобритания

Л. Хануш

Институт исследования лекарств, Еврейский университет Иерусалима, Израиль

Email: lumirh@ekmd.huji.ac.il
Professor, Hebrew University’s School of Pharmacy
Address: Jerusalem, Israel, The Hebrew University of Jerusalem Израиль

Ж.-М. Пей

Четвертый военно-медицинский университет, Ксиань, провинция Шаанкси, Китай

Email: Jmpei8@fmmu.edu.cn

Professor, Department of Physiology, Fourth Military Medical University
Address: 710032, Shaanxi Province, China, West Changle Road, Xi’an

Китай

И. Жанг

Медицинский университет Хебея, Шиджиажуанг, провинция Хебей, Китай

Email: zhyhenry@hotmail.com

Professor, Department of Physiology, Hebei Medical University
Address: Shijiazhuang 050017, China, 361, East Zhongshan Road

Китай

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