ROLES OF DIFFERENT MACROPHAGE PHENOTYPES IN THE PATHOGENESIS OF SOME HUMAN DISEASES

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Abstract

Macrophages have recently been shown to play a key role in promoting of recovery after some diseases as well as in aggravation of inflammatory responses, all the functions being resulted from microenvironmental conditions and therefore phenotypes acquired by macrophages in these conditions. In this article some protective functions of macrophages during infectious and oncologic diseases as well as pathogenic roles in a number of inflammatory diseases are reviewed. Much attention is devoted to opportunities of macrophage reprogramming.

About the authors

V. N. Sakharov

Sechenov First Moscow State Medical University, Russian Federation

Author for correspondence.
Email: vladimirsah91@mail.ru
аспирант кафедры патофизиологии лечебного факультета Первого Московского государственного медицинского университета им. И.М. Сеченова
Адрес: 119992, Москва, ул. Трубецкая, д. 8, стр. 2, тел.: +7 (495) 708-34-81 Russian Federation

P. F. Litvitskii

Sechenov First Moscow State Medical University, Russian Federation

Email: litvicki@mma.ru
доктор медицинских наук, профессор, член-корреспондент РАН, заведующий кафедрой патофизиологии лечебного факультета Первого Московского государственного медицинского университета им. И.М. Сеченова
Адрес: 119992, Москва, ул. Трубецкая, д. 8, стр. 2, тел.: +7 (495) 708-34-81

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