MOLECULAR AND PHARMACOGENETIC MECHANISMS OF SEVERE ASTHMA
- Authors: Kulikov E.S.1, Ogorodnova L.M.1, Freidin M.B.2, Deev I.A.1, Selivanova P.A.1, Fedosenko S.V.1, Kirillova N.A.1
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Affiliations:
- Siberian State Medical University, Tomsk, Russian Federation
- Research Institute of Medical Genetics, Tomsk, Russian Federation
- Issue: Vol 68, No 3 (2013)
- Pages: 15-23
- Section: РATHOPHYSIOLOGY: CURRENT ISSUES
- Published:
- URL: https://vestnikramn.spr-journal.ru/jour/article/view/200
- DOI: https://doi.org/10.15690/vramn.v68i3.596
- ID: 200
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Full Text
Abstract
This review summarizes the results of studies to identify the dominant mechanisms of development and persistence of inflammation in severe asthma and results of pharmacogenetic studies of determination response to drugs. These mechanisms could potentially be used for diagnostic purposes and become the new targets of asthma therapy. Pharmacogenetic information will enable the use of a personalized approach to the asthma management which will adjust the therapy technology and increase the possibility of achieving disease control.
Keywords
About the authors
E. S. Kulikov
Siberian State Medical University, Tomsk, Russian Federation
Author for correspondence.
Email: evgeny.s.kulikov@gmail.com
кандидат медицинских наук, ассистент кафедры общей врачебной практики с курсом поликлинической терапии ГБОУ ВПО СибГМУ Минздрава России
Адрес: 634050, Томск, Московский тракт, д. 2; тел.: (3822) 51-49-67
L. M. Ogorodnova
Siberian State Medical University, Tomsk, Russian Federation
Email: lm-ogorodova@mail.ru
доктор медицинских наук, профессор, член-корреспондент РАМН, заведующая кафедрой факультетской педиатрии с курсом детских болезней лечебного факультета ГБОУ ВПО СибГМУ Минздрава России
Адрес: 634050, Томск, Московский тракт, д. 2; тел.: (3822) 51-49-67
M. B. Freidin
Research Institute of Medical Genetics, Tomsk, Russian Federation
Email: mfreidin@medgenetics.ru
кандидат биологических наук, старший научный сотрудник лаборатории популяционной генетики ФГБУ «НИИ медицинской генетики» СО РАМН
Адрес: 634050, Томск, ул. Набережная р. Ушайки, д. 10; тел.: (3822) 42-09-56
I. A. Deev
Siberian State Medical University, Tomsk, Russian Federation
Email: ivandeyev@yandex.ru
доктор медицинских наук, профессор кафедры факультетской педиатрии с курсом детских болезней лечебного факультета ГБОУ ВПО СибГМУ Минздрава России
Адрес: 634050, Томск, Московский тракт, д. 2; тел.: (3822) 51-49-67 Russian Federation
P. A. Selivanova
Siberian State Medical University, Tomsk, Russian Federation
Email: p.selivanova@mail.ru
кандидат медицинских наук, ассистент кафедры госпитальной терапии с курсом физической реабилитации и спортивной медицины ГБОУ ВПО СибГМУ Минздрава России
Адрес: 634050, Томск, Московский тракт, д. 2; тел.: (3822) 51-49-67 Russian Federation
S. V. Fedosenko
Siberian State Medical University, Tomsk, Russian Federation
Email: s-fedosenko@mail.ru
кандидат медицинских наук, ассистент кафедры госпитальной терапии с курсом физической реабилитации и спортивной медицины ГБОУ ВПО СибГМУ Минздрава России
Адрес: 634050, Томск, Московский тракт, д. 2; тел.: (3822) 51-49-67 Russian Federation
N. A. Kirillova
Siberian State Medical University, Tomsk, Russian Federation
Email: kirillova.natalya@gmail.com
кандидат медицинских наук, ассистент кафедры общей врачебной практики с курсом поликлинической терапии ГБОУ ВПО СибГМУ Минздрава России
Адрес: 634050, Томск, Московский тракт, д. 2; тел.: (3822) 51-49-67
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