IMMUNOLOGIC INDEXES, ENZYME STATUS OF LYMPHOCYTES AND FUNCTIONAL ACTIVITY OF BLOOD NEUTROPHILS IN CHILDREN WITH INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN–BARR VIRUS

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Abstract

Aim. Explore the immunological parameters, levels of activity of NAD(P)-dependent dehydrogenases lymphocytes, interferon status parameters, phagocytic activity and chemiluminescence response of neutrophils in the blood of children in the acute phase of infectious mononucleosis caused by the Epstein-Barr virus. Patients and methods. 65 children at the age of 4–6 years old with infectious mononucleosis caused by EBV in acute phase were observed. Such indexes as cell-mediated, humoral and interferon immunity, NAD(P)-depended dehydrogenases activity in blood lymphocyte, phagocytes activity, levels of spontaneous and induced chemiluminescence of peripheral blood neutrophils were studied. Results. Children with EVB-infection have immunophenotype spectrum changes and changes of enzymes status of blood lymphocytes against the increasing in leucocytes and the useful increasing in lymphocytes. The useful increasing in IgA, IgM, IgG contenting in serum blood were found. The decreasing of spontaneous production of IFN α and the decreasing of induced production of IFN α, IFN γ were determined. The breach of phagocytes activity and chemiluminescent response of blood neutrophils were found. Conclusions. The children in the acute phase of infectious mononucleosis caused by the Epstein-Barr virus, there are changes in the immune status, changes the activity of NAD(P)-dependent dehydrogenases in blood lymphocytes, marked changes in functional and metabolic state of peripheral blood neutrophils.

 

About the authors

L. M. Kurtasova

Voyno-Yasenetsky Krasnoyarsk State Medical University, Russian Federation

Author for correspondence.
Email: office@aids.krsn.ru
PhD, Professor, Department of Clinical Immunology, Krasnoyarsk State Medical University named after Prof. V. F. Voyno-Yasenetsky Address: 660022, Krasnoyarsk, Partizan Zheleznyaka St., 1/1; tel.: (391) 227-24-13 Russian Federation

A. E. Tolstikova

Medical Research Institute for Northern Problems of Siberian Division of RAMS, Krasnoyarsk, Russian Federation

Email: a-golovanova@mail.ru
PhD student for the Degree of Candidate of Biological Sciences, Medical Research Institute for Northern Problems Siberian Branch of RAMS Address: 660022, Krasnoyarsk, Partizan Zheleznyaka St., 3G; tel.: (391) 212-52-63 Russian Federation

A. A. Savchenko

Medical Research Institute for Northern Problems of Siberian Division of RAMS, Krasnoyarsk, Russian Federation

Email: aasavchenko@yandex.ru
PhD, Professor, Head of the Molecule-cellular Physiology and Pathology Laboratory, Medical Research Institute for Northern Problems Siberian Branch of RAMS Address: 660022, Krasnoyarsk, Partizan Zheleznyaka St., 3G; tel.: (391) 212-52-63 Russian Federation

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