ELECTROPHYSIOLOGICAL MARKERS OF MIDDLE CEREBRAL ARTERY BLOOD FLOW VELOCITY IN HEALTHY SUBJECTS

Cover Page


Cite item

Full Text

Abstract

Aim: to determine electrophysiological markers of middle cerebral artery blood flow velocity (BFV). Patients and methods: transcranial Doppler registration of middle cerebral artery BFV and direct current  (DC) potentials recording from surface of head were performed in 30 healthy volunteers. Analysis of correlation between the BFV and DC potentials was used. Results: significant correlation between BFV and DC potential characteristics was observed. The highest correlation was found between BFV in middle cerebral artery and the difference of DC potentials between central and temporal areas of head (r =0,55; p =0,003). These areas coincide with the location of middle cerebral artery and the correlation observed may be connected with streaming potential generated by the blood flow in middle cerebral artery. If electrode placement did not coincide with blood current, DC potentials and BFV were not correlated. Conclusions: it is assumed that electrical field created BFV in middle cerebral artery may contribute to the generation of DC potentials registered from the head.

 

About the authors

V. F. Fokin

Research Centre of Neurology RAMS, Moscow, Russian Federation

Author for correspondence.
Email: fvf@mail.ru
PhD, professor, Head of the development brain physiology department of the Federal State Budgetary Institution “Scientific Center of Neurology” of RAMS. Address: 80, Volokolamskoye Route, Moscow, 125367, tel.: (495) 917-07-65 Россия

N. V. Ponomareva

Research Centre of Neurology RAMS, Moscow, Russian Federation

Email: ponomare@yandex.ru
PhD, leading research scientist, Head of the genetic and physiological mechanisms of brain aging group of the Federal State Budgetary Institution “Scientific Center of Neurology” of RAMS. Address: 80, Volokolamskoye Route, Moscow, 125367, tel.: (495) 917-07-65 Россия

G. I. Kuntsevich

Research Centre of Neurology RAMS, Moscow, Russian Federation

Email: doctorkunsevich@mail.ru
PhD, professor, Head of the ultrasonic investigations laboratory of the Federal State Budgetary Institution “Scientific Center of Neurology” of RAMS. Address: 80, Volokolamskoye Route, Moscow, 125367, tel.: (495) 490-24-07 Россия

References

  1. Sawyer P.N., Himmelfarb E., Lustrin I, Ziskind H. Measurement of streaming potentials of mammalian blood vessels, aorta and vena cava, in vivo. Biophys. J. 1966; 6; 641–651.
  2. Trivedi D.P., Hallock K.J., R.Bergethon P.R. Electric fields caused by blood flow modulate vascular endothelial electrophysiology and nitric oxide production. Bioelectromagnetics. 2013; 34; 22–30.
  3. Bergethon P.R. Altered electrophysiologic and pharmacologic response of smooth muscle cells on exposure to electrical fields generated by blood flow. Biophys. J. 1991; 60; 588–595.
  4. Fokin V.F., Ponomareva N.V. Energeticheskaya fiziologiya mozga. [Energetic Physiology of the Brain]. Мoscow, Antidor, 2003. 288 p.
  5. Revest P.A., Jones H.C., Abbott N.J. Transendothelial electrical potential across pial vessels in anaesthetised rats: a study of ion permeability and transport at the blood-brain barrier. Brain Res. 1994; 652 (1): 76-82.
  6. Fokin V.F., Ponomareva N.V. The intensity of cerebral energy metabolism: the possibility of its evaluation of electrophysiological methods. Vestnik Rossiiskoi akademii meditsinskikh nauk = Annals of the Russian Academy of Medical Sciences. 2001; 8: 38–43.
  7. Voipio J., Tallgren P., Heinonen E., Vanhatalo S., Kaila K. Millivolt-scale DC shifts in the human scalp EEG: evidence for a nonneuronal generator. J. Neurophysiol. 2003; 89: 2208–2214.
  8. Suslina Z.А. Neurology at the turn of the century: achievements and prospects. Vestnik Rossiiskoi akademii meditsinskikh nauk = Annals of the Russian Academy of Medical Sciences. 2012; 8: 57–65.
  9. Kuntsevich G.I. Ul’trazvukovye metody issledovaniya vetvei dugi aorty. [Ultrasonic Methods of Aortic Arch Branches Research]. Minsk, Aversev, 2006. 205 p.
  10. Fokin V.F., Ponomareva N.V., Krotenkova M.V. et al. Conjugation of changes in the characteristics of the local cerebral blood flow and slow the electrical activity of the brain in patients with circulatory encephalopathy. Vestnik Rossiiskoi akademii meditsinskikh nauk = Annals of the Russian Academy of Medical Sciences. 2011; 7: 42–45.
  11. Vanhatalo S., Talgren P., Becker C., et al. Scalp recorder slow EEG responses generated in response to hemodynamic changes in human brain. Clin. Neurophysiol. 2003; 114: 1744–1754.
  12. Barakat A.I., Lieu D.K. Differential Responsiveness of Vascular Endothelial Cells to Different Types of Fluid Mechanical Shear Stress. Cell biochemistry and Biophysyc. 2003; 38: 323–344.
  13. Callies C., Fels J., Liashkovich I., Kliche K., Jeggle P., Kusche-Vihrog K., Oberleithner H. Membrane potential depolarization decreases the stiffness of vascular endothelial cells. Journal of Cell Science. 2011; 124: 1936–1942.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 1970 "Paediatrician" Publishers LLC



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies