Causes and Factors of Male Infertility

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Abstract

The preservation of reproductive health of the population is an important factor of demographic policy of the state. According to some authors from 14 to 30% of couples of reproductive age suffer from infertility, male factor in such marriages is detected in more than half of the cases. As you know, in recent years there has been a significant deterioration in the main indicators of reproductive function of men. Increased the number of andrological diseases, morphological disorders of the male reproductive system, almost halved the production of sperm in men of reproductive age. The reason probably lies behind a whole range of stress factors, such as medical ignorance, uncontrolled and inappropriate use of medication, metabolic disturbances, lack of vitamins and minerals, the impact of industrial pollutants, as well as the growth of addictive disorders (alcoholism, smoking and drug addiction). The forms of infertility differ according to its etiology and severity from minor changes to complete spermatogenesis dysfunction of the gonads, and can also occur due to genetic disorders. The lack of analysis of the relationship between clinical and genetic-biochemical components in men with infertility makes it impossible to understand the pathogenesis of infertility and to assess the risks of male infertility. High level of current medicine does not always guarantee an identification of the cause of male infertility. The article analyzes data from the review of specialized literature on the diagnosis and etiopathogenesis of male infertility. Frequency and clinical signs of pathology of the male reproductive system depend on the combinatorial effects of environmental influences, manifested most often in mutually reinforcing effect. A combination of several, seemed to be imperceptible factors makes the risk of development of male reproductive pathology very high. This situation compels specialists to conduct comprehensive studies on the men reproductive potential.

About the authors

L. I. Kolesnikova

Scientifi c Centre for Family Health and Human Reproduction Problems, Irkutsk, Russian Federation

Author for correspondence.
Email: iphr@sbamsr.irk.ru

доктор медицинских наук, профессор, член-корреспондент РАН, научный руководитель НЦ ПЗСРЧ Адрес: 664003, Иркутск, ул. Тимирязева, д. 16, тел.: +7 (3952) 20-76-36

Russian Federation

S. I. Kolesnikov

Scientifi c Centre for Family Health and Human Reproduction Problems, Irkutsk, Russian Federation

Email: iphr@sbamsr.irk.ru

академик РАН, главный научный сотрудник НЦ ПЗСРЧ Адрес: 664003, Иркутск, ул. Тимирязева, д. 16, тел.: +7 (3952) 20-76-36

Russian Federation

N. A. Kurashova

Scientifi c Centre for Family Health and Human Reproduction Problems, Irkutsk, Russian Federation

Email: nakurashova@yandex.ru

кандидат биологических наук, научный сотрудник лаборатории патофизиологии репродукции НЦ ПЗСРЧ Адрес: 664003, Иркутск, ул. Тимирязева, д. 16, тел.: +7 (3952) 20-76-36

Russian Federation

T. A. Bairova

Scientifi c Centre for Family Health and Human Reproduction Problems, Irkutsk, Russian Federation

Email: iphr@sbamsr.irk.ru

доктор медицинских наук, заведующая лабораторией персонализированной медицины НЦ ПЗСРЧ Адрес: 664003, Иркутск, ул. Тимирязева, д. 16, тел.: +7 (3952) 20-76-36

Russian Federation

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