Causes and Factors of Male Infertility

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The preservation of reproductive health of the population is an important factor of demographic policy of the state. According to some authors from 14 to 30% of couples of reproductive age suffer from infertility, male factor in such marriages is detected in more than half of the cases. As you know, in recent years there has been a significant deterioration in the main indicators of reproductive function of men. Increased the number of andrological diseases, morphological disorders of the male reproductive system, almost halved the production of sperm in men of reproductive age. The reason probably lies behind a whole range of stress factors, such as medical ignorance, uncontrolled and inappropriate use of medication, metabolic disturbances, lack of vitamins and minerals, the impact of industrial pollutants, as well as the growth of addictive disorders (alcoholism, smoking and drug addiction). The forms of infertility differ according to its etiology and severity from minor changes to complete spermatogenesis dysfunction of the gonads, and can also occur due to genetic disorders. The lack of analysis of the relationship between clinical and genetic-biochemical components in men with infertility makes it impossible to understand the pathogenesis of infertility and to assess the risks of male infertility. High level of current medicine does not always guarantee an identification of the cause of male infertility. The article analyzes data from the review of specialized literature on the diagnosis and etiopathogenesis of male infertility. Frequency and clinical signs of pathology of the male reproductive system depend on the combinatorial effects of environmental influences, manifested most often in mutually reinforcing effect. A combination of several, seemed to be imperceptible factors makes the risk of development of male reproductive pathology very high. This situation compels specialists to conduct comprehensive studies on the men reproductive potential.

About the authors

L. I. Kolesnikova

Scientifi c Centre for Family Health and Human Reproduction Problems, Irkutsk, Russian Federation

Author for correspondence.

доктор медицинских наук, профессор, член-корреспондент РАН, научный руководитель НЦ ПЗСРЧ Адрес: 664003, Иркутск, ул. Тимирязева, д. 16, тел.: +7 (3952) 20-76-36

Russian Federation

S. I. Kolesnikov

Scientifi c Centre for Family Health and Human Reproduction Problems, Irkutsk, Russian Federation


академик РАН, главный научный сотрудник НЦ ПЗСРЧ Адрес: 664003, Иркутск, ул. Тимирязева, д. 16, тел.: +7 (3952) 20-76-36

Russian Federation

N. A. Kurashova

Scientifi c Centre for Family Health and Human Reproduction Problems, Irkutsk, Russian Federation


кандидат биологических наук, научный сотрудник лаборатории патофизиологии репродукции НЦ ПЗСРЧ Адрес: 664003, Иркутск, ул. Тимирязева, д. 16, тел.: +7 (3952) 20-76-36

Russian Federation

T. A. Bairova

Scientifi c Centre for Family Health and Human Reproduction Problems, Irkutsk, Russian Federation


доктор медицинских наук, заведующая лабораторией персонализированной медицины НЦ ПЗСРЧ Адрес: 664003, Иркутск, ул. Тимирязева, д. 16, тел.: +7 (3952) 20-76-36

Russian Federation


  1. Danilova T.I., Tikhomirova V.Yu., Mel'nikova E.A., Khludeev V.N. Cryptorchidism and modern approach to the prevention of male infertility. Tikhookeanskii meditsinskii zhurnal = Pacific medical journal. 2006;4:59–60.
  2. Sallmen М., Sandler D., Hoppin J.A., Blair A., Baird D.D. Reduced fertility among overweight and obese men. Epidemiology. 2006; 17 (5): 520–523.
  3. Shantanova L.N., Osadchuk L.V., Dashiev B.G., Kleshchev M.A., Gutorova N.V., Osadchuk A.V., Bashelkhanov I.S. Evaluation of the reproductive health of young men of the Republic of Buryatia. Byulleten' VSNTs SO RAMN = Bulletin of ESSC of SD of RAMS. 2012;6(88):44–46.
  4. Panayiotis M.Z., Khalied K., Juan R.C., Suresh C.S. Seminal Characteristics and Sexual Behavior in Men of Different Age Groups: Is There an Aging Effect? Asian J. Androl. 2006; 8 (3):337–341.
  5. Glybochko P.V., Alyaev Yu.G., Vinarov A.Z., Demidko Yu.L., Akhvlediani N.D, Baiduvaliev A.M. Use of an inhibitor of phosphodiesterase type 5 in the rehabilitation of patients with chronic prostatitis. Effektivnaya farmakoterapiya = Effective pharmacotherapy. 2013;53:30–35.
  6. Glybochko P.V., Alyaev Yu.G., Chalyi M.E., Barashkov G.K., Usacheva O.A. Infertility and patozoospermiya after surgical treatment of varicocele. Farmateka = Pharmateca. 2013;3(256):35–37.
  7. Labygina A.V., Zagarskikh E.Yu., Suturina L.V., Kurashova N.A. Adolescent Reproductive Health in Eastern Siberia the main ethnic groups living in rural areas. Byulleten' VSNTs SO RAMN = Bulletin of ESSC of SD of RAMS. 2013;4(92):36–40.
  8. Baranov A.A., Namazova-Baranova L.S., Il'in A.G. Maintenance and health promotion of adolescent – pledge of sustainable development of society and state (current status of the issue). Vestnik RAMN = Annals of the Russian academy of medical sciences. 2014;5–6:65–70. doi: 10.15690/vramn.v69i5-6.1046
  9. Carlsen E., Giwercman A., Keiding N., Skakkebaek N.E. Evidence for decreasing quality of semen during past 50 years. BMJ. 1992; 305 (6854): 609–613.
  10. Jorgensen N., Andersen A.G., Eustache F., Irvine D.S., Suominen J., Petersen J.H., Andersen A.N., Auger J., Cawood E.H.H., Horte A., Kold J.T., Jouannet P., Keiding N., Vierula M., Toppari J., Skakkebæk N.E. Regional differences in semen quality in Europe. Hum. Reprod. 2001; 16: 1012–1019.
  11. Iwamoto T., Nozawa S., Yoshiike M., Hoshino T., Baba K., Matsushita T., Tanaka S.N., Naka M., Skakkebæk N.E., Jørgensen N. Semen quality of 324 fertile Japanese men. Hum. Reprod. 2006; 21:760–765.
  12. Swan S.N., Brasil C., Drobnis E.Z., Liu F, Kruse R.L., Hatch M., Redmon J.B., Wang C., Overstreet J.W. Geographic differences in semen quality of fertile U.S. males. Environ. Health Perspect. 2003;111: 414–420.
  13. Kleshchev M.A., Osadchuk L.V., Gutorova N.V., Tipisova U.V., Osadchuk L.V. Analysis of spermatogenic function in male population of the city of Arkhangelsk. Andrologiya i genital'naya khirurgiya = Andrology and genital surgery. 2011;2:56–60.
  14. Osadchuk L.V., Kleshchev M.A., Temnikov N.D., Erkovich A.A., Osadchuk AV. High incidence of suboptimal sperm quality among residents of the Siberian region (by the example of Novosibirsk). Andrologiya i genital'naya khirurgiya = Andrology and genital surgery. 2010;3:52–55.
  15. Goncharova N.N., Martyshkina E.Yu., Kaznacheeva T.V., Arslanyan K.N., Adamyan L.V., Kurilo L.F., Sorokina T.M., Chernykh V.B. Medical and genetic aspects of infertility. Akusherstvo. Ginekologiya. Reproduktsiya = Obstetrics. Gynecology. Reproduction. 2012;2:35–40.
  16. Osadchuk L.V., Erkovich A.A., Tataru D.A., Markova E.V., Svetlakov A.V. he level of DNA fragmentation in human sperm varicocele and prostatitis. Urologiya = Urology. 2014;3:37–43.
  17. Markova E.V., Zamai A.S. Fragmentation of the DNA of human sperm. Problemy reproduktsii = Problems of reproduction. 2006;12(4):42–50.
  18. Vityazeva I.I., Bogolyubov S.V., Dedov I.I. Modern technology in the treatment of azoospermia by microdissection TECE in IVF-ICSI. Part 1. Problemy endokrinologii = Problems of endocrinology. 2012;58(5):66–74.
  19. Chernyak Y.I., Itskovich V.B., Kolesnikov S.I. Effects of CYP1A2 gene polymorphisms on antipyrine CYP1A2 dependent metabolism. Bull. Exp. Biol. Med. 2011; 151 (4): 445–448.
  20. Baranov V.S., Ailamazyan E.K. Environmental and genetic causes of reproductive disorders and their prevention. Zhurnal akusherstva i zhenskikh boleznei = Journal of Obstetrics and gynecological diseases. 2007;LVI(1):3–10.
  21. Bozhedomov V.A., Gromenko D.S., Ushakova I.Ya., Toroptseva M.V., Galimov Sh.N., Aleksandrova L.A., Teodorovich O.V., Sukhikh G.T. Oxidative stress in the pathogenesis of sperm of male infertility. Urologiya = Urology. 2009;2:51–56.
  22. Kolesnikova L.I., Vlasov B.Ya., Neronova N.A., Kirilenko E.A., Atalyan A.V., Kurashova N.A., Batunova E.V., Bardaeva Yu.M., Tonkoshkurova T.Yu. Reproductive function, lipid peroxidation and antioxidant protection in men with chronic infection monotrihomonadnoy. Fundamental'nye issledovaniya = Basic research. 2011;1:76–81.
  23. Bozhedomov V.A., Gromenko D.S., Ushakova I.Ya. Causes of oxidative stress. Problemy reproduktsii = Problems of reproduction. 2008;3(14):63.
  24. Tremellen K. Oxidative stress and of male infertility. Hum. Reproduct. Update. 2008; 14 (3): 243–258.
  25. Il'in V.P., Kolesnikova L.I., Suturina L.V., Labygina A.V., Sholokhov L.F., Kurashova N.A. Features hormone-metabolic disorders in women with hypothalamic syndrome, depending on the body mass index. Byulleten' VSNTs SO RAMN = Bulletin of ESSC of SD of RAMS. 2004;2-1:117–121.
  26. Khyshiktuev B.S., Koshmelev A.A. Characteristics of changes in phospholipid composition of semen in men with impaired fertility. Klinicheskaya laboratornaya diagnostika = Clinical laboratory services. 2010;7:27–30.
  27. Aitken R.J., Whiting S., De Iuliis G.N., McClymont S., Mitchell L.A., Baker M.A. Electrophilic aldehydes generated by sperm metabolism activate mitochondrial reactive oxygen species generation and apoptosis by targeting succinate dehydrogenase. J. Biol. Chem. 2012; 39(287): 33048–33060.
  28. Galimova E.F. Characteristics of glutathione metabolism in idiopathic male infertility. Problemy reproduktsii = Problems of reproduction. 2013;3:51-53.
  29. Kolesnikova L.I., Bairova T.A., Pervushina O.A. Ethnogenetic markers of antioxidant system. Byulleten' VSNTs SO RAMN = Bulletin of ESSC of SD of RAMS. 2013;4(92):166–171.
  30. Sharma R., Yang Y., Sharma A., Awasthi S., Awasthi Y.C. Antioxidant role of glutathione-S-transferases: protection against oxidant toxicity and regulation of stress-mediated apoptosis. Antioxid. Redox. Signal. 2006; 6: 289–300.
  31. Miao L., Clair D.K. Regulation of superoxide dismutase genes: Implications in disease. Free Radic. Biol. Med. 2009; 47: 344–350.
  32. Zini A., Carrels K., Phang D. Antioxidant activity in the semen of fertile and infertile men. Urology. 2000; 55: 922–926.
  33. Wu J.P., Xing–Tang, K.F., Xue W., Liu M., Sun J.H., Wang X.Y., Jin X.J. Genetic polymorphism of glutathione S-transferase T1 gene and susceptibility to idiopatic azoospermia or oligozoospermia in north western. China Asian J. Androl. 2008; 10: 266–270.
  34. El'chaninova S.A., Popovtseva A.V., Zolovkina A.G., Aliev R.T., Nozdrachev N.A., Krainichenko S.V., Neimark A.I. Features semen parameters and metabolism of reactive oxygen species in the ejaculate of patients with chronic abacterial prostatitis. Klinicheskaya laboratornaya diagnostika = Clinical laboratory services. 2009; 7: 21–22.
  35. Glybochko P.V., Alyaev Yu.G., Demidko Yu.L., Myannik S.A. Application of herbal medicines in the treatment of chronic prostatitis. Effektivnaya farmakoterapiya = Effective pharmacotherapy. 2012;43:26–31.
  36. Kasturi S.S., Tannir J., Brannigan R.E. The methabolic syndrome and male infertility. J. Androl. 2008; 29: 251–259.
  37. Tyuzikov I.A. Metabolic syndrome and male infertility (review). Andrologiya i genital'naya khirurgiya = Andrology and genital surgery. 2013;(2):5–9.
  38. Schwartz V. Adipose tissue as an endocrine organ. Problemy endokrinologii = Problems of endocrinology. 2009;55(1):38–50.
  39. Ter-Avanesov G.V. Korrektsiya reproduktivnoi funktsii muzhchin pri endokrinnykh narusheniyakh. Prakt. ruk-vo [Correction of Reproductive Function of Men with Endocrine Disorders. Guidelines]. Moscow, 2002. 63 p.
  40. Agbaje I.M., Rogers D.A., McVicar C.M., McClure N., Atkinson A.B., Mallidis C., Lewis S.E. Insulin dependent diabetes mellitus: implications for male reproductive function. Hum. Reprod. 2007; 22: 1871–1877.
  41. Hossain F., Ali O., D’Souza U.J., Naing D.K. Effects of Pesticide Use on Semen Quality among Farmers in Rural Areas of Sabah, Malaysia. J. Occur. Health. 2010; 52 (6): 353–360.
  42. Nikitin A.I. Disappearing gender? Morfologiya = Morphology. 2003;124(6):80–89.
  43. Lutskii D.L., Vybornov S.V., Lutskaya A.M., Goncharova L.A., Makhmudov R.M. Influence of chemical factors on the male reproductive system. Problemy reproduktsii = Problems of reproduction. 2009; 6: 48–64.
  44. Tokar' V.I. O patogeneze narushenii v sisteme gipotalamusgipofiz–gonady pri khronicheskoi ftoristoi intoksikatsii. Sb. tezisov konferentsii «Endokrinnaya sistema organizma i vrednye faktory vneshnei sredy» [On Pathogenesis of the System Gipotalamusgipofiz-Gonads in Chronic Fluoride Intoxication. Coll. of abstracts "Endocrine System of Body and Harmful Environmental Factors"]. Moscow, 1983. P. 194.
  45. Kolstad H., Bunde J.P.E., Spano M. Giwercman A., Zschiesche W., Kaae D., Roeleveld N. Sperm chromatin structure and semen quality following occupational styrene exposure. Scand. J. Work Environ. Health. 1999; 1: 70–73.



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