MOLECULAR MECHANISMS OF FORMATION OF BLOOD EOSINOPHILIA UNDER PULMONARY TUBERCULOSIS

Cover Page

Abstract


Molecular factors of pathogenesis of the eosinophilic blood reaction under pulmonary tuberculosis are analyzed in the article. It has been established that the key cytokine providing the development of hemic eosinophilia in patients with pulmonary tuberculosis is IL-5. IL-5 plasma concentration turned out to be increased only in patients with eosinophilia. Increase of eotaxin was determined in patients with tuberculosis despite of the presense of eosinophilia. One-directional nature of the defined changes in eotaxin concentration might be explained by dual properties of this chemokine: on the one hand, eotaxin mediates long-term presence of eosinophils in blood; on the other hand, it initiates the process of adhesion of eosinophilic leucocytes to vascular endothelium with their further migration to the focus of granulomatous inflammation. The established increase in number of IL-5R-positive eosinophils presents one more mechanism which explains the basis of long-term presence of eosinophils in peripheral blood in patients with pulmonary tuberculosis.

 


About the authors

Yu. V. Kolobovnikova

State budgetary educational institution of higher professional education «Siberian State Medical University» of the Ministry of Health and Social Development of Russian Federation

Author for correspondence.
Email: kolobovnikova.julia@mail.ru

Russian Federation кандидат медицинских наук, ассистент кафедры патофизиологии ГБОУ ВПО СибГМУ Минздравсоцразвития России, Адрес: 634050, Томск, Московский тракт, д. 2 Тел.: (3822) 55-36-13

O. I. Urazova

State budgetary educational institution of higher professional education «Siberian State Medical University» of the Ministry of Health and Social Development of Russian Federation

Email: urazova72@yandex.ru

Russian Federation доктор медицинских наук, профессор кафедры патофизиологии ГБОУ ВПО СибГМУ Минздравсоцразвития России Адрес: 634050, Томск, Московский тракт, д. 2 Тел.: (3822) 55-36-13

V. V. Novitskii

State budgetary educational institution of higher professional education «Siberian State Medical University» of the Ministry of Health and Social Development of Russian Federation

Email: office@ssmu.net.ru

Russian Federation академик РАМН, профессор, заведующий кафедрой патофизиологии ГБОУ ВПО СибГМУ Минздравсоцразвития России Адрес: 634050, Томск, Московский тракт, д. 2 Тел.: (3822) 55-36-13

K. O. Mikheeva

State budgetary educational institution of higher professional education «Siberian State Medical University» of the Ministry of Health and Social Development of Russian Federation

Email: mko1986@sibmail.com

Russian Federation аспирант кафедры патофизиологии ГБОУ ВПО СибГМУ Минздравсоцразвития России Адрес: 634050, Томск, Московский тракт, д. 2 Тел.: (3822) 55-36-13

M. D. Goncharov

State budgetary educational institution of higher professional education «Siberian State Medical University» of the Ministry of Health and Social Development of Russian Federation

Email: mko1986@sibmail.com

Russian Federation студент 6-го курса медико-биологического факультета ГБОУ ВПО СибГМУ Минздравсоцразвития России Адрес: 634050, Томск, Московский тракт, д 2 Тел.: (3822) 55-36-13

References

  1. VoronLova O.V., Urazova O.I., NovitcLii` V.V., Strelis A.K. Immunopatologiia tuberLuleza legLikh. Tomsq: Izd-vo Tom. un-ta. 2007. 194 s.
  2. Kirman J. Role of eosinophils in the pathogenesis of Mycobacterium bovis BCG infection in gamma interferon receptor-deficient mice. Infect. Immun. 2009; 68 (5): 2976–2978.
  3. Lasco T.M. Rapid Accumulation of Eosinophils in Lung Lesions in Guinea Pigs Infected with Mycobacterium tuberculosis. Infect. Immun. 2004; 72 (2): 1147–1149.
  4. -JUWJOPWB - 4 3ZB[BOUTFWB / 7 /PWJUTLJJ 7 7 ,MFUPDIOZF NF† LIBOJ[NZ bol`shikh eozinofilii` Lrovi. TomsL: Izd-vo Tom. un-ta. 2007. 138 s.
  5. Mordvinov V.A., Furman D.P. TDitoLiny`: biologichesLie svoi`stva i reguliatciia eLspressii gena interleiLina-5 cheloveLa. 7FTUOJL VOGiS. 2009; 13 (1): 53–67.
  6. Hogan S.P. Eosinophils: Biological Properties and Role in Health and Disease. Clinical & Experimental Allergy. 2008; 38: 709–750.
  7. Liadova I.V., Gergert V.Ia. Reaqtcii T-Lletochnogo immuniteta pri tuberLuleze: eLsperimental`ny`e i LlinichesLie issledovaniia. Tuberqulez i bolezni legqikh. 2009; 11: 9–18.
  8. Barnes P.J. Differential regulation of human eosinophil IL-3, IL-5, and GM-CSF receptor alpha-chain expression by cytokines. J. Immunol. 2003; 1 (5): 167–175.
  9. Nagase H., Miyamasu M., Yamaguchi M. Regulation of chemokine receptor expression in eosinophils. Arch. Allergy Immunol. 2001; 1 (10): 29–32.
  10. Mordvinov V.A., Sanderson C.J. Regulation of IL-5 expression. Arch. Immunol. Ther. Exp. (Warsz). 2001; 5 (1): 345–351.
  11. Garcia-Zepeda E.A., Rothenberg M.E., Ownbey R.T. et al. Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. Nat. Med. 1996; 2: 449–456.
  12. Jose P.J., Griffiths-Johnson D.A., Collins P.D. et al. Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. J. Exp. Med. 1994; 179: 881–887.
  13. Fulkerson P.C., Fischetti C.A., Rothenberg M.E. Eosinophils and CCR3 regulate interleukin-13 transgene-induced pulmonary remodeling. Am. J. Pathol. 2006; 169 (6): 2117–2126.
  14. Park Y.M., Bochner B.S. Eosinophil Survival and Apoptosis in Health and Disease. Allergy Asthma Immunol. Res. 2010, 2 (2): 87–101.
  15. Tavernier J., Devos R., Cornelis S.et al. A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α-chain and a β chain shared with the receptor for GM-CSF. Cell. 2001; 66 (7): 1175

Statistics

Views

Abstract - 303

PDF (Russian) - 277

Cited-By


Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM

PlumX

Dimensions



Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies