THE PERSONALIZED APPROACH TO ANTIHYPERTENSIVE THERAPY DURING PREGNANCY IN TERMS OF CLINICAL PHARMACOGENETICS

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Abstract

The right drug at the right dose administered to a patient in time is the goal which all medical specialists aim at when prescribing medicines to patients. Pregnancy is a condition when the principle of personalized pharmacotherapy is especially relevant. Due to the developing fetus and the occurring changes in the maternal organism, the selection of drug therapy during pregnancy is especially difficult for a clinician. This issue is tightly intertwined with clinical pharmacogenetics since the genetic code of a woman that determines the activity of the liver cytochrome, the fetus-placental barrier, and renal clearance contributes to the peculiarities of the drug metabolism during pregnancy. Additional data provides the opportunities to form therapeutic models and to determine the ways of personifying pharmacotherapy in pregnancy. The purpose of this review is to summarize the available data on the pharmacogenetics of antihypertensive drugs used during pregnancy.

About the authors

I. V. Ignatko

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: iradocent@mail.ru
ORCID iD: 0000-0002-9945-3848

Irina V. Ignatko -MD, PhD, Professor.

Moscow

Russian Federation

L. A. Strizhakov

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: strizhakov76@mail.ru
ORCID iD: 0000-0002-2291-6453

Leonid A. Strizhakov - MD, PhD, Professor.

Moscow

Russian Federation

V. S. Florova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: Florova.violetta@gmail.com
ORCID iD: 0000-0003-1483-8819

Violetta S. Frolova – MD.

Moscow

Russian Federation

A. L. Martirosova

City Clinical Hospital № 29 named after N.E. Bauman

Email: martirosova@inbox.ru
ORCID iD: 0000-0002-5763-7593

Alina L. Martirosova – MD.

Moscow

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