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The Study of Influence of Different Methods of Local Treatment on Wound Healing in Patients with Diabetic Foot Ulcers
- Authors: Zaitseva E.L.1, Tokmakova A.Y.1, Shestakova M.V.1, Galstyan G.R.1, Doronina L.P.1
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Affiliations:
- Endocrinology Research Centre
- Issue: Vol 71, No 6 (2016)
- Section: ENDOCRINOLOGY: CURRENT ISSUES
- URL: https://vestnikramn.spr-journal.ru/jour/article/view/735
- DOI: https://doi.org/10.15690/vramn735
- ID: 735
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Abstract
Aim. To evaluate the influence of different methods of local treatment on tissue repair in patients with diabetic foot ulcers.
Materials and methods. We evaluated such clinical characteristics as wound size and local perfusion after using negative pressure wound therapy (NPWT), local collagen, and standard care in patients with diabetic foot ulcers. We observed 63 patients with neuropathic and neuroischemic forms of diabetic foot (without critical ischemia) after surgical debridement. After that 21 patients received NPWT, 21 local collagen treatment and 21 ― standard care.
Results. After using NPWT wound area and depth decreased in 19,8% and 42,8% (p<0.05), in group of collagen dressings in 26,4 and 30,4% (p<0.05). In control group those parameters were 17,0 и 16.6% respectively (p<0.05). There was found the significant increase of local perfusion according to oxygen monitoring in group of NPWT (p<0.05).
Conclusion. The received data showed that the intensity of lower limb tissue repair processes increases more significant after using NPWT and collagen dressings in comparison to standard care which is found according to wound size and tissue perfusion alterations.
Keywords
About the authors
E. L. Zaitseva
Endocrinology Research Centre
Author for correspondence.
Email: zai.kate@gmail.com
Moscow, Russian Federation Russian Federation
A. Yu. Tokmakova
Endocrinology Research Centre
Email: alla-tokmakova@yandex.ru
Moscow, Russian Federation
M. V. Shestakova
Endocrinology Research Centre
Email: nephro@endocrincenr.ru
ORCID iD: 0000-0002-5057-127X
Moscow, Russian Federation
G. R. Galstyan
Endocrinology Research Centre
Email: ggalstyan964@gmail.com
ORCID iD: 0000-0001-6581-4521
Moscow, Russian Federation
L. P. Doronina
Endocrinology Research Centre
Email: doronina.l@mail.ru
Moscow, Russian Federation
References
- International Working Group on the Diabetic Foot. IWGDF Guidance on the management and prevention of foot problems in diabetes 2015 [Internet]. Amsterdam; 2015 [cited 2016 Sep 9]. Available from: http://iwgdf.org/guidelines/.
- Дедов И.И., Шестакова М.В., Галстян Г.Р., и др. Алгоритмы специализированной медицинской помощи больным сахарным диабетом (7 выпуск). Под ред. И.И. Дедова, М.В. Шестаковой // Сахарный диабет. ― 2015. ― Т.18. ― №1S ― C. 1–112. [Dedov II, Shestakova MV, Galstyan GR, et al. Standards of specialized diabetes care. Edited by Dedov I.I., Shestakova M.V. (7th edition). Diabetes mellitus. 2015;18(1S):1–112. (In Russ)]. doi: 10.14341/DM20151S1-112.
- Christman AL, Selvin E, Margolis DJ, et al. Hemoglobin A1c predicts healing rate in diabetic wounds. J Invest Dermatol. 2011;131(10):2121–2127. doi: 10.1038/jid.2011.176.
- Lavery LA, Murdoch DP, Kim PJ, et al. Negative pressure wound therapy with low pressure and gauze dressings to treat diabetic foot wounds. J Diabetes Sci Technol. 2014;8(2):346–349. doi: 10.1177/1932296813519012.
- Зайцева Е.Л. Клинические, морфологические и иммуногистохимические особенности репарации мягких тканей нижних конечностей у больных с синдромом диабетической стопы на фоне различных методов местного лечения: дис. … канд. мед. наук. — М.; 2015. — С. 78–87. [Zaitseva EL. Klinicheskie, morfologicheskie i immunogistokhimicheskie osobennosti reparatsii myagkikh tkanei nizhnikh konechnostei u bol’nykh s sindromomdiabeticheskoi stopy na fone razlichnykh metodov mestnogo lecheniya. [dissertation] Moscow; 2015. p. 78–87. (In Russ).]
- Kakagia DD, Kazakos KJ, Xarchas KC, et al. Synergistic action of protease-modulating matrix and autologous growth factors in healing of diabetic foot ulcers. A prospective randomized trial. J Diabetes Complications. 2007;21(6):387–391. doi: 10.1016/j.jdiacomp.2007.03.006.
- Горюнов С.В., Абрамов И.С., Чапарьян Б.А., и др. Руководство по лечению ран методом управляемого отрицательного давления. ― М.: Апрель; 2013. — 130 с. [Goryunov SV, Abramov IS, Chapar’yan BA, et al. Rukovodstvo po lecheniyu ran metodom upravlyaemogo otritsatel’nogo davleniya. Moscow: Aprel’; 2013. (In Russ).]
- Wollina U, Schmidt WD, Kronert C, et al. Some effects of a topical collagen-based matrix on the microcirculation and wound healing in patients with chronic venous leg ulcers: preliminary observations. Int J Low Extrem Wounds. 2005;4(4):214–224. doi: 10.1177/1534734605283001.
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