Degradome Components in Progression of Squamous Cell Carcinoma of the Head and Neck

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Abstract

The process of tumor progression is closely related to the intracellular, extracellular and intramembranous proteolysis. Many studies indicate that the proteases function as part of an extensive multidirectional network of proteolytic interactions. Disturbance of strictly controlled equilibrium of the proteolytic system is described in a number of diseases, including cancer. The paper presents a review of the available data concerning the contribution of intracellular, extracellular and intramembrane proteolysis to the process of squamous cell head and neck carcinoma. Specific mechanisms of interaction of different proteolytic systems in cancer progression both in general and in squamous cell head and neck carcinoma remain underinvestigated. The versatility of functions and complexity of the relationships between proteolytic systems highlights the importance of studying the participation of all degradome components in tumor progression that may clarify the multi-link complex mechanisms of carcinogenesis of squamous cell head and neck carcinoma and to identify markers of progression and/or a targets for therapeutic intervention.

About the authors

Gelena Valer'evna Kakurina

Tomsk Cancer Research Institute

Author for correspondence.
Email: kakurinagv@oncology.tomsk.ru
MD, PhD, Cheif researcher Russian Federation

Irina Viktorovna Kondakova

Tomsk Cancer Research Institute

Email: kondakova@oncology.tomsk.ru
MD, PhD, Head of the tumor biochemistry laboratory Russian Federation

Evgeniy Lkhamatsyrenovich Choynzonov

Tomsk Cancer Research Institute

Email: info@oncology.tomsk.ru
MD, PhD, Professor, Academician of the Russian Academy of Sciences, Director of the Tomsk Cancer Research Institute Russian Federation

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