PREDICTIVE VALUE OF HODGKIN’S LYMPHOMA TUMOR BURDEN IN PRESENT

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Abstract

Today approximately 70% of patients with Hodgkin lymphoma can be cured with the combined-modality therapy. Tumor burden, the importance of which was demonstrated at first 15 years ago, is a powerful prognostic factor. Data of literature of representations on predictive value of Hodgkin’s lymphoma tumor burden are shown in the article. The difficult immunological relations between tumor cells and reactive ones lead to development of the main symptoms. Nevertheless, the collective sign of tumor burden shows the greatest influence on survival and on probability of resistance, which relative risk can be predicted on this variable and treatment program. Patients with bulky disease need escalated therapy with high-dose chemotherapy. Integration into predictive models of the variable will change an expected contribution of clinical and laboratory parameters in the regression analyses constructed on patients with Hodgkin's lymphoma. Today the role of diagnostic functional methods, in particular a positron emission tomography, for metabolic active measurement which allows excluding a reactive component is considered.

About the authors

S. A. Kuleva

N.N. Petrov Research Institute of Oncology, St. Petersburg, Russian Federation
Saint-Petersburg State Pediatric Medical University, Russian Federation

Author for correspondence.
Email: Kulevadoc@yandex.ru
доктор медицинских наук, детский онколог отделения химиотерапии и комби- нированного лечения злокачественных опухолей у детей НИИ онкологии им. Н.Н. Петрова, профессор кафедры онкологии с курсом лучевой диагностики и лучевой терапии СПбГПМУ Адрес: 197758, Санкт-Петербург, пос. Песочный, ул. Ленинградская, д. 68, тел.: +7 (812) 439-95-10 Russian Federation

A. P. Karitskii

N.N. Petrov Research Institute of Oncology, St. Petersburg, Russian Federation

Email: 9515321@mail.ru
кандидат медицинских наук, главный врач НИИ онкологии им. Н.Н. Петрова Адрес: 197758, Санкт-Петербург, пос. Песочный, ул. Ленинградская, д. 68, тел.: +7 (812) 439-95-40 Russian Federation

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