CLINICAL SIGNIFICANCE OF INSULIN RESISTANCE SYNDROME IN DEVELOPMENT OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH PRIMARY GOUT

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Abstract

Endothelial function has been studied in 175 males with primary gout. It has been established that incidence of endothelial dysfunction in patients with primary gout was associated with the clinical course and was marked most of all in patients who had a chronic gout. The correlations found between the parameters of endothelial dysfunction and impaired carbohydrate metabolism suggest close link and coordination between the above processes which contribute greatly to development and progress of atherosclerosis in such patients.

About the authors

N. N. Kushnarenko

Chita State Medical Academy Ministry of Healthcare and Social development of Russia, Chita, Russia

Author for correspondence.
Email: pochta@medacadem.chita.ru
кандидат медицинских наук, заведующая кафедрой внутренних болезней стома- тологического и педиатрического факультетов Читинской государственной медицинской академии. Russian Federation

A. V. Govorin

Chita State Medical Academy Ministry of Healthcare and Social development of Russia, Chita, Russia

Email: pochta@medacadem.chita.ru
доктор медицинских наук, профессор, заслуженный врач РФ, ректор ГОУ ВПО Читинской государственной медицинской академии, заведующий кафедрой факультетской терапии. Russian Federation

O. A. Shcherbakova

Chita State Medical Academy Ministry of Healthcare and Social development of Russia, Chita, Russia

Email: pochta@medacadem.chita.ru
Russian Federation

S. G. Sotnikova

Chita State Medical Academy Ministry of Healthcare and Social development of Russia, Chita, Russia

Email: pochta@medacadem.chita.ru
Russian Federation

O. V. Ivanitskaya

Chita State Medical Academy Ministry of Healthcare and Social development of Russia, Chita, Russia

Email: pochta@medacadem.chita.ru
Russian Federation

References

  1. Namakanov B.A., Rasulov M.M. Kardiovaskulyarnaya terapiya i profilaktika = Cardiovascular therapy and prophylaxis. 2005; 4 (6): 98−101.
  2. Trusov V.V., Filimonov M.A., Aksenov K.V. Kardiovaskulyarnaya terapiya i profilaktika = Cardiovascular therapy and prophylaxis. 2005; 4 (6): 62−66.
  3. Petrischev N.N. Disfunktsiya endoteliya: prichiny, mekhanizmy, farmakologicheskaya korrektsiya [Endothelial Dysfunction: Etiology, Mechanisms, Pharmacological Correction]. St. Petersburg, SPbGMU, 2003. 184 p.
  4. Furchgott R.F, Vanhoutte P.M. Еndothelium-derived relaxing and contracting factors. FASEB J. 1989; 3: 2007−2018.
  5. Rackley C.E. Endothelial UpToDate. 2002; 10. Available at: http://www.uptodate.com
  6. Kanellis J., Kang D.H. Uric acid as a mediator of endothelial dysfunction, inflammation and vascular diseas. Semin. Nephrol. 2005; 25: 39−42.
  7. Lapkina N.A., Baranov A.A., Barskova V.G. et al. Ter. arhiv = Therapeutic archive. 2005; 6: 62−65.
  8. Laakso M., Sarlund H., Mykkanen L. Insulin resistance is associated with lipid and lipoprotein abnormalities in subject with varying degrees of glucose tolerance. Arteriosclerosis. 1990; 10: 223−231.
  9. Wallace К.L., Riedel A.A., Joseph-Ridge N. et al. Increasing prevalence of gout and hyperuricemia over 10 years among older adult in a managed care population. J. Rheumatol. 2004; 31: 1582−1587.
  10. Ivanova O.V., Rogoza A.N., Balahonova T.V. et al. Kardiologiya = Cardiology. 1998; 3: 37−41.
  11. Hollenbeck C.B., Chen N., Chen Y.-D. I., Reaven G.М. Relationship between the plasma insulin response to oral glucose and insulin-stimulated glucose utilization in normal subjects. Diabetes. 1984; 33: 460−463.
  12. Rojtberg G.E. Metabolicheskii sindrom [Metabolic Syndrome]. Moscow, 2007.
  13. Zatejschikova A.A., Zatejschikov D.A. Kardiologiya = Cardiology. 1998; 9: 68−76.
  14. ESH-ESC Guidelines Committee. ESH-ESC guidelines for the management of arterial hypertension. J. Hypertens. 2007; 21: 1011−1053.
  15. Vogel R.A. Coronary risk factors, endothelial function, and atherosclerosis: a review. Clin. Cardiol. 1997; 20: 426−432.

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