ESTROGEN RECEPTORS Β — NEW TARGET IN CELLULAR LUNG CANCER TREATMENT

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Abstract

Literature review upon various types of estrogen receptors expression (type ? and ?) in the cells of cellular lung cancer, their participation in estrogen and antiestrogen effects implementation, influence of estrogens and antiestrogens on occurrence and progression of malignant lung tumors in animals and humans. Were analyzed reasons of data ambiguity on type ? estrogen receptors (ER?) expression frequency. The results of authors own research in quantitative assessment of ER? expression in tumor tissue of patients with cellular lung cancer (79 male and 22 female patients are presented in this article. An increase in expression rate and incidence of tumors with high ER? level has been shown in patients with lung adenocarcinoma regardless of smoking status or gender. A new strategy of antiestrogen use, especially tamoxifen, has been formulated for cellular lung cancer treatment. Authors believe in a positive effect of adjuvant treatment with tamoxifen in patients with ER?-positive cellular lung cancer used independently or during and after the chemotherapy, by analogy with breast cancer patients.


About the authors

M. I. Davydov

FSBI «Blokhin Russian oncological scientific centre» RAMS, Moscow

Email: bogush@orc.ru
доктор медицинских наук, академик РАН и РАМН, профессор, директор Российского онкологического научного центра имени. Н.Н. Блохина РАМН Адрес: 115478, Москва, Каширское шоссе, д. 24 Тел./факс: (495) 932-85-68 Russian Federation

T. A. Bogush

FSBI «Blokhin Russian oncological scientific centre» RAMS, Moscow

Author for correspondence.
Email: bogush@orc.ru
доктор биологических наук, профессор, заслуженный деятель науки РФ, заведующая лабораторией медицинской химии Российского онкологического научного центра имени Н.Н. Блохина РАМН Russian Federation

B. E. Polotskii

FSBI «Blokhin Russian oncological scientific centre» RAMS, Moscow

Email: bogush@orc.ru
доктор медицинских наук, профессор, ведущий научный сотрудник Российского онколо- гического научного центра имени Н.Н. Блохина РАМН Russian Federation

S. A. Tyulyandin

FSBI «Blokhin Russian oncological scientific centre» RAMS, Moscow

Email: bogush@orc.ru
доктор медицинских наук, профессор, руководитель отделения клинической фармако- логии и химиотерапии Российского онкологического научного центра имени Н.Н. Блохина РАМН Russian Federation

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