FUNDAMENTAL AND APPLIED ASPECTS OF THE BLOOD-BRAIN BARRIER RESEARCH

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Abstract

The results of fundamental and applied studies of blood-brain barrier had been conducted by authors during the last 10 years are summarized in the publication. The molecular anatomy of barrier microvessels, as well as promising markers of BBB and other proteins involved in barrier functions are discussed. Via in vitro experiments with endothelial cells of cerebral microvessels we characterized the basic conditions required for adequate BBB modeling. The in vivo data of BBB permeability for macromolecules in normal and different pathological processis including radiation injury, hyperosmotic shock, and nervous tissue ischemia are properly described. A particular attention was focused upon the experimental studies of the permeability and functional reorganization of barrier endothelium during tumor neoangiogenesis. We detected a dramatically increased permeability of neoplastic microvessels both for horseradish peroxidase/serum albumin and labeled monoclonal antibodies. The increased tumor permeability for IgG and the overexpression of target antigens in tumor tissue and peritumoral zone make possible the targeted delivery of diagnostics and therapeutic agents into the tumor by means of monoclonal antibodies.

 

About the authors

V. P. Chekhonin

Pirogov Russian National Medical Research University Ministry of Healthcare and Social Development of Russia, Moscow
Federal State Institution «Serbsky State scientific centre of social and forensic psychiatry» Ministry of Healthcare
and Social development, Moscow

Author for correspondence.
Email: chekhoninnew@yandex.ru
академик РАМН, доктор медицинских наук, профессор, академик-секретарь РАМН, руководитель отдела фундаментал ьной и прикладной нейробиологии ГНЦССП им. В.П. Сербского, руководитель отдела медицинских нанобиотехнологий РНИМУ им. Н.И. Пирог ова Адрес: 119991, Москва, Кропоткинский пер., д. 23 Тел.: (495) 695-02-62, факс: (495) 637-50-55 Russian Federation

V. P. Baklaushev

Pirogov Russian National Medical Research University Ministry of Healthcare and Social Development of Russia, Moscow
Federal State Institution «Serbsky State scientific centre of social and forensic psychiatry» Ministry of Healthcare
and Social development, Moscow

Email: serpoff@mail.ru
кандидат медицинских наук, доцент кафедры медицинских нанобиотехно- логий РНИМУ им. Н.И. Пирогова, в.н.с. отдела фундаментальной и прикладной нейробиологии ГНЦССП им. В.П. Сербского Адрес: 119991, Москва, Кропоткинский пер., д. 23 Тел.: (495)695-02-62, факс (495)637-50-55 Russian Federation

G. M. Yusubalieva

Pirogov Russian National Medical Research University Ministry of Healthcare and Social Development of Russia, Moscow
Federal State Institution «Serbsky State scientific centre of social and forensic psychiatry» Ministry of Healthcare
and Social development, Moscow

Email: kakonya@gmail.com
кандидат медицинских наук, ассистент кафедры медицинских нанобиотехно- логий РНИМУ им. Н.И. Пирогова, с.н.с. отдела фундаментальной и прикладной нейробиологии ГНЦССП им. В.П. Сербского Адрес: 119991, Москва, Кропоткинский пер., д. 23 Тел.: (495)695-02-62, факс (495)637-50-55 Russian Federation

N. E. Volgina

Pirogov Russian National Medical Research University Ministry of Healthcare and Social Development of Russia, Moscow
Federal State Institution «Serbsky State scientific centre of social and forensic psychiatry» Ministry of Healthcare
and Social development, Moscow

Email: volginadi@gmail.com
аспирант кафедры медицинских нанобиотехнологий РНИМУ им. Н.И. Пирогова Адрес: 119991, Москва, Кропоткинский пер., д. 23 Тел.: (495)695-02-62, факс (495)637-50-55 Russian Federation

O. I. Gurina

Federal State Institution «Serbsky State scientific centre of social and forensic psychiatry» Ministry of Healthcare
and Social development, Moscow

Email: olga672@yandex.ru
доктор медицинских наук, руководитель лаборатории нейрохимии отдела фундаментальной и прикладной нейробиологии ГНЦССП им. В.П. Сербского. Адрес: 119991, Москва, Кропоткинский пер., д. 23 Тел.: (495)695-02-62, факс (495)637-50-55. Russian Federation

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