CLINICAL AND EXPERIMENTAL RESEARCH OF IMMUNOMODULATORY EFFECT OF AMISULPRIDE

Cover Page


Cite item

Full Text

Abstract

Study of immunomodulatory effect of atypical antipsychotic amisulpride has revealed a positive clinical effect after 6-week therapy of schizophrenic patients regarding both positive and negative symptoms. A decrease in activity of humoral immunity factors (В lymphocytes, immunoglobulins, HLA-DR+-cells) identified among schizophrenic patients in the process of amisulpride therapy can be attributed to a positive effect optimizing the ratio Th1/Th2. Amisulpride when used under experimental conditions produced a suppression of IgM-immune response in mice of the C57BL/6J strain. This effect was more expressed in animals with aggressive behavior pattern.

 

About the authors

T. P. Vetlugina

Mental Health Research Institute under the Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Russian Federation

Author for correspondence.
Email: vetlug@mail.tomsknet.ru
PhD, Professor, Head of Laboratory of Clinical Psychoneuroimmunology, Federal State Budget Institution Scientific Research Institute of Physical Health, Siberian Department, Russian Academy of Medical Sciences. Address: 634014, Tomsk, Aleutskaya str. 4; Tel.: (3822) 72-44-15 Russian Federation

O. A. Lobacheva

Mental Health Research Institute under the Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Russian Federation

Email: oalobacheva@sibmail.com
PhD, Leading Scientific Worker, Laboratory of Clinical Psychoneuroimmunology, Federal State Budget Institution Scientific Research Institute of Physical Health, Siberian Department, Russian Academy of Medical Sciences. Address: 634014, Tomsk, Aleutskaya str. 4; Tel.: (3822) 72-44-15 Russian Federation

E. L. Al'perina

Research Institute of Physiology under the Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russian Federation

Email: e.l.alperina@physiol.ru
PhD, Chief Scientific Worker, Laboratory of Neurochemical Modulation Mechanisms, Federal State Budget Institution Scientific Research Institute of Physiology, Siberian Department, Russian Academy of Medical Sciences. Address: 630117, Novosibirsk, Academician Timakov str. 4; Tel.: (383) 335-98-58 Russian Federation

E. N. Zhukova

Research Institute of Physiology under the Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russian Federation

Email: maktub.9@mail.ru
Candidate of Biological Sciences, Scientific Worker, Laboratory of Neurochemical Modulation Mechanisms, Federal State Budget Institution Scientific Research Institute of Physiology, Siberian Department, Russian Academy of Medical Sciences. Address: 630117, Novosibirsk, Academician Timakov str. 4; Tel.: (383) 335-98-58 Russian Federation

A. V. Semke

Mental Health Research Institute under the Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Russian Federation

Email: asemke@mail.ru
PhD, Professor, Head of Endogenic Disorders Department, Federal State Budget Institution Scientific Research Institute of Psychical Health, Siberian Department, Russian Academy of Medical Sciences. Address: 634014, Tomsk, Aleutskaya str. 4; Tel.: (3822) 72-31-51 Russian Federation

V. B. Nikitina

Mental Health Research Institute under the Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Russian Federation

Email: valentina08@sibmail.com
PhD, Leading Scientific Worker, Laboratory of Clinical Psychoneuroimmunology, Federal State Budget Institution Scientific Research Institute of psychical Health, Siberian Department, Russian Academy of Medical Sciences. Address: 634014, Tomsk, Aleutskaya str. 4; Tel.: (3822) 72-44-15 Russian Federation

M. A. Cheido

Research Institute of Physiology under the Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russian Federation

Email: cheido@physiol.ru
Candidate of Biological Sciences, Leading Scientific Worker, Laboratory of Neurochemical Modulation Mechanisms, Federal State Budget Institution Scientific Research Institute of Physiology, Siberian Department, Russian Academy of Medical Sciences. Address: 630117, Novosibirsk, Academician Timakov str. 4; Tel.: (383) 335-97-58 Russian Federation

G. V. Idova

Research Institute of Physiology under the Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russian Federation

Email: galina@physiol.ru
PhD, Professor, Head of Laboratory of Neurochemical Modulation Mechanisms, Federal State Budget Institution Scientific Research Institute of Physiology, Siberian Department, Russian Academy of Medical Sciences. Address: 630117, Novosibirsk, Academician Timakov str. 4; Tel.: (383) 335-97-58 Russian Federation

References

  1. Mosolov S.N., Ryvkin P.V., Serditov O.V., Ladyzhenskii M.Ya., Potapov A.V. Metabolic side effects of modern antipsychotic drug therapy. Sotsial'naya i klinicheskaya psikhiatriya = Social and clinical psychiatry. 2008; 3: 75–90.
  2. Gorobets L.N., Matrosova M.I., Shmukler A.B. Dynamics of clinical and endocrine, hormonal, biochemical, anthropometric and physical performance in patients with schizophrenia and schizophrenia spectrum disorders during treatment with sertindole. Sotsial'naya i klinicheskaya psikhiatriya = Social and clinical psychiatry. 2010; 20 (3): 59–67.
  3. Muller N., Schwarz M. Immunology in schizophrenic disorders. Nervenarzt. 2007; 78 (3): 253–256, 258–260, 262–263.
  4. Khaitov R.M., Pinegin B.V. Evaluation of the immune status of human health and disease. Immunologiya = Immunology. 2001; 4: 4–6.
  5. Kudryavtseva N.N., Bakshtanovskaya I.V. Neurochemical control of aggression and submission. Zhurn. vyssh.nervn. deyat. = Journal of Higher Nervous Activity. 1991; 41 (3): 459–466.
  6. Devoino L., Idova G., Alperina E., Cheido M. Brain neuromediator systems in the immune response control: pharmacological analysis of pre- and postsynaptic mechanisms. Brain Res. 1994; 633: 267–274.
  7. Seeman P. All roads to schizophrenia lead to dopamine supersensitivity and elevated dopamine D2 (high) receptors. CNS Neurosci Ther. 2011; 17 (2): 118–132.
  8. Avedisova A.S., Yastrebov D.V. Amisulpride (Solian): The most atypical of atypical neuroleptics. Farmateka = Pharmateca. 2006; Spets. vypusk, 2: 2–6.
  9. Kryzhanovskii G.N., Magaeva S.V., Makarov S.P., Sepiashvili R.I. Neiroimmunopatologiya. Ruk-vo [Neuroimmunopathology. Manual]. Moscow, NII obshchei patologii i patofiziologii, 2003. 438 p.
  10. Devoino L.V., Idova G.V., Al'perina E.L. Psikhoneiroimmunomodulyatsiya: povedenie i immunitet. Rol' «neiromediatornoi ustanovki mozga [Psychoneuroimmunomodulation: Behavior and Immunity. The Role of "Brain Neurotransmitter Installation”]. Novosibirsk, Nauka, 2009. 167 p.
  11. Semke V.Ya., Vetlugina T.P., Nevidimova T.I., Ivanova S.A., Bokhan N.A. Klinicheskaya psikhoneiroimmunologiya [Clinical Psychoneuroimmunology]. Tomsk, RASKO, 2003. 300 p.
  12. Lobacheva O.A., Naidenova N.N., Vetlugina T.P. Cytokines in schizophrenia. Patogenez = Pathogenesis. 2006. 4 (1): 59–60.
  13. Vetlugina T.P., Nevidimova T.I.. Lobacheva O.A., Nikitina V.B. Tekhnologiya immunokorrektsii pri psikhicheskikh rasstroistvakh [Technology Immunomodulation in Mental Disorders]. Tomsk, Izd-vo Tom. un-ta. 2010. 172 p.
  14. Watanabe Y., Someya T., Nawa H.. Cytokine hypothesis of schizophrenia pathogenesis: evidence from human studies and animal models. Psychiatry Clin. Neurosci. 2010. 64 (3): 217–230.
  15. Devoino L., Alperina E., Galkina O., Ilyutchenok R. Involvement of brain dopaminergic structures in neuroimmunomodulation. Intern. J. Neurosci. 1997; 91 (3–4): 213–228.
  16. Idova G.V., Alperna E.L., Cheido M.A. Contribution of brain dopamine, serotonin and opioid receptors in the mechanisms of neuroimmunomodulation: evidence from pharmacological analysis. Int. Immunopharmacol. 2012; 12 (4): 618–625.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2012 "Paediatrician" Publishers LLC



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies