TOXICOLOGICAL EVALUATION OF NANODISPERSED MANGANESE OXIDE (III, IV) EFFECT ON MORPHOLOGICAL PECULIARITIES OF DIFFERENT TISSUES UNDER EXPERIMENT

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Abstract

The study of morphological features of tissue organs of experimental animals after a single intragastric administration of an aqueous suspension nanodis-dispersed manganese (III, IV) at doses of 2000, 3500 and 5000 mg/kg showed complex of morphological changes in the form of circulatory disorders up to hemostasis and bleeding which lead to changes in the structure of organs, enhanced apoptosis, activation of macrophage system by proliferation and macrophage phagocytosis of degradation products of cells, hypertrophy of lymphoid tissue of immune system; development of histiocytic infiltrates in parenchymal organs and central nervous system. With the introduction of microsized analogues in the same doses of the morphological changes in the circulatory system, macrophage system and immune organs found predominantly in a dose of 5000 mg/kg. Changes were less significant and were presented as activation of macrophages in the liver in the form of activation of Kupffer cells, proliferation of lymphoid tissue in the spleen, lymph histiocytic infiltrates in the liver, kidney, medium size.

About the authors

N. V. Zaitseva

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, Russian Federation

Author for correspondence.
Email: root@fcrisk.ru

PhD, Professor, RAMS academician, Honored Worker of Science of Russian Federation, Director of Federal Scientific Center for Medical and Preventive Health Risk Management Technologies Address: 614045, Perm, Monastyrskaya St., 82; tel.: (342) 237-25-34

Russian Federation

M. A. Zemlyanova

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, Russian Federation

Email: zem@fcrisk.ru
PhD, Head of Department of Biochemical and Сytogenetic Diagnostics Federal Scientific Center for Medical and Preventive Health Risk Management Technologies Address: 614045, Perm, Monastyrskaya St., 82; tel.: (342) 236-39-30 Russian Federation

V. N. Zvezdin

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, Russian Federation

Email: zvezdin@fcrisk.ru
Junior Research Worker, Cytogenetics laboratory, Federal Scientific Center for Medical and Preventive Health Risk Management Technologies Address: 614045, Perm, Monastyrskaya St., 82; tel.: (342) 237-25-34 Russian Federation

O. V. Lebedinskaya

E.A. Wagner Perm State Medical Academy, Perm, Russian Federation

Email: lebedinska@mail.ru
PhD, Associate Professor, Department of Histology, Cytology and Embryology, Perm State Medical Academy named after Ac. E.A. Wagner Address: Perm, 614000, Petropavlovskaya St., 26; tel.: (342) 217-10-30 Russian Federation

S. V. Melekhin

E.A. Wagner Perm State Medical Academy, Perm, Russian Federation

Email: rector@psma.ru
Assistant, Department of Histology, Cytology and Embryology, Perm State Medical Academy named after Ac. E.A. Wagner Address: Perm, 614000, Petropavlovskaya St., 26; tel.: (342) 217-10-30 Russian Federation

E. V. Saenko

Institute of Technical Chemistry, Ural Branch of the Russian Academy of Sciences, Perm, Russian Federation

Email: saenko_ekaterina@mail.ru
PhD, Senior Research Worker, Laboratory of Multiphase Dispersible Systems, Institute of Technical Chemistry Ural Branch of Russian Academy of Sciences Address: 614013, Perm, Ac. Koroleva St., 3, tel.: (342) 237-82-72 Russian Federation

R. R. Makhmudov

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, Russian Federation

Email: bav@psu.ru

PhD, Senior Research Worker, Metabolism and Pharmacokinetics Research Laboratory, Federal Scientific Center for Medical and Preventive Health Risk Management Technologies Address: 614045, Perm, Ordzhonikidze St., 82; tel.: (342) 237-25-34

Russian Federation

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