THE INFLUENCE OF THE BUPIVACAINE REGIONAL ANESTHESIA ON THE CONTRACTILE ACTIVITY OF THE UTERUS AND THE FUNCTIONAL STATE OF THE FETUS

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Abstract

The study in chronic experiment on 26 pregnant  rabbit females induced in labor by oxytocin on the 30th day of pregnancy was conducted. The effects of bupivacaine (0,5% - 1 ml) epidural anesthesia (EA) on the contractile activity of the uterus, the functional state of the females and their fetuses were studied. On  the 28th day of pregnancy under thiopental anesthesia electrodes were administered: to the fetus - ECG, in the female myometrium - for recording electrical activity. In order to check the uterus mechanical activity the original sensor was used filled by graphite, which was placed around one horn of the uterus. The contractile activity of the myometrium was evaluated for each 5-minute interval by the number of uterine contractions, duration and amplitude of one uterine contraction. The functional state of female fetuses and rabbit female were evaluated by the frequency change of the heart rate.  In 12 females occured to delivery. Registration of uterine contractions, heart rate of the female and fetuses were carried out simultaneously and continuously throughout the whole experiment. It was shown that under standard conditions EA didn’t induce changes in uterine activity parameters of the female located in its natural position, and didn’t affect on the fetal heart rate (3-factor analysis of variance - ANOVA). 10 minutes after EA, the momentary acceleration of female heart rate (9%) was recorded in relation to the reference level, which may be associated with transient hypotension. Thus, in conditions of our experience the bupivacaine (0,5% -1,0 ml) EA in induced labor of female rabbit has no significant effect on the uterus contractile activity and the functional state of the fetus. Short-term adaptive tachycardia is registered in females.

About the authors

E. V. Bazizyan

Ott Institute of Obstetrics and Gynecology, Saint-Petersburg, Russian Federation

Author for correspondence.
Email: waz2107gen@yandex.ru
Research Worker, Laboratory of Physiology and Pathophysiology of Fetus with Ultrasound Department, Research Institute of Obstetrics and Gynecology named after D.O. Otta Address: 199034, St. Petersburg, Mendeleev line 3; tel.: (812) 328-98-14 Russian Federation

N. N. Konstantinova

Ott Institute of Obstetrics and Gynecology, Saint-Petersburg, Russian Federation

Email: ngp05@yandex.ru
PhD, Professor, Leading Research Worker, Laboratory of Physiology and Pathophysiology of Fetus with Ultrasound Department, Research Institute of Obstetrics and Gynecology named after D.O. Otta Address: 199034, St. Petersburg, Mendeleev line 3; tel.: (812) 328-98-14 Russian Federation

L. A. Nazarova

Ott Institute of Obstetrics and Gynecology, Saint-Petersburg, Russian Federation

Email: ngp05@yandex.ru
PhD, Senior Research Worker, Laboratory of Physiology and Pathophysiology of Fetus with Ultrasound Department, Research Institute of Obstetrics and Gynecology named after D.O. Otta Address: 199034, St. Petersburg, Mendeleev line 3; tel.: (812) 328-98-14

V. A. Pervak

Ott Institute of Obstetrics and Gynecology, Saint-Petersburg, Russian Federation

Email: med-tehno@yandex.ru
PhD, Physician of the Anesthesiology, Reanimation and Intensive Therapy Department, Research Institute of Obstetrics and Gynecology named after D.O. Otta Address: 199034, St. Petersburg, Mendeleev line 3; tel.: (812) 328-98-14 Russian Federation

N. G. Pavlova

Ott Institute of Obstetrics and Gynecology, Saint-Petersburg, Russian Federation

Email: ngp05@yandex.ru
PhD, Professor, Head of the Laboratory of Physiology and Pathophysiology of Fetus with Ultrasound Department, Research Institute of Obstetrics and Gynecology named after D.O. Otta Address: 199034, St. Petersburg, Mendeleev line 3; tel.: (812) 328-98-14 Russian Federation

References

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