POTENTIAL SENSITIVITY TO METFORMIN OF THE DIABETICS SUFFERING AND NOT SUFFERING WITH CANCER: A PHARMACOGENETIC STUDY

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Abstract

The group (totally156 postmenopausal women) used for the study of ‘standard’ (S) and ‘associated’ (A) genetic markers of potential sensitivity to metformin (MF) consisted of 37 healthy females, 32 — with diabetes (DM) without cancer, 64 cancer patients with DM, and 23 cancer patients without DM. No significant difference in carrying of S-polymorphisms was found between DM patients without and with cancer. In cancer patients without DM most characteristic data regarding potential MF-response were detected with polymorphisms of STK11 gene while data on OCT1_rs622342 and OCT1_R61C variants showed opposite trends. In regard of A-markers, the tendency to the more often finding of GC genotype of OLR1_G501C in DM patients carrying ‘MF-positive’ variant of OCT1_R61C deserves to be underlined. In patients with new-onset diabetes who carried S-markers of potential response to MF higher insulin resistance (OCT1_R61C and OCT1_rs622342) as well as lower estradiolemia (STK11 and C11orf65) were discovered. Thus, according to genetic S-criteria of sensitivity to MF, DM patients with and without cancer differ in lesser degree than they differ from cancer patients without DM. It can not be excluded, that The efficiency of such criteria might be increased due to combination with A-markers and certain hormonal-metabolic indices.

 

About the authors

L. M. Berstein

N.N. Petrov Research Institute of Oncology, St.Petersburg, Russian Federation

Author for correspondence.
Email: levmb@endocrin.spb.ru
PhD, professor, Head of the Laboratory of Oncoendocrinology of FSBI “N.N. Petrov Research Institute of Oncology”. MD, professor, head of Laboratory of Oncoendocrinology, Federal State Budget Institution “N.N. Petrov Scientific Research Institute of Oncology” Address: 68, Leningradskaya Street, Pesochnii, St. Petersburg, RF, 197758; tel.: +7 (812) 439-9536 Russian Federation

A. G. Ievleva

N.N. Petrov Research Institute of Oncology, St.Petersburg, Russian Federation

Email: aglayai@inbox.ru
MD, research scientist of Molecular Oncology Laboratory of FSBI “N.N. Petrov Research Institute of Oncology”. Address: 68, Leningradskaya Street, Pesochnii, St. Petersburg, RF, 197758; tel.: +7 (812) 439-9528 Russian Federation

D. A. Vasil'ev

N.N. Petrov Research Institute of Oncology, St.Petersburg, Russian Federation

Email: dvasilyev@hotmail.com
MD, senior research scientist of Oncoendocrinology Laboratory of FSBI “N.N. Petrov Research Institute of Oncology”. Address: 68, Leningradskaya Street, Pesochnii, St. Petersburg, RF, 197758; tel.: +7 (812) 439-9536 Russian Federation

I. M. Kovalenko

N.N. Petrov Research Institute of Oncology, St.Petersburg, Russian Federation

Email: ira_dv@mail.ru
research scientist of Oncoendocrinology Laboratory of FSBI “N.N. Petrov Research Institute of Oncology”. Address: 68, Leningradskaya Street, Pesochnii, St. Petersburg, RF, 197758; tel.: +7 (812) 439-9536 Russian Federation

E. N. Imyanitov

N.N. Petrov Research Institute of Oncology, St.Petersburg, Russian Federation

Email: evgeny@imyanitov.spb.ru
PhD, professor, Head of the Department of Tumor Growth Biology of FSBI “N.N. Petrov Research Institute of Oncology”. Address: 68, Leningradskaya Street, Pesochnii, St. Petersburg, RF, 197758; tel.: +7 (812) 439-9528 Russian Federation

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