USE OF MATHEMATICAL MODELS INFRARED SPECTROSCOPY SERUM IN THE DIFFERENTIAL DIAGNOSIS OF ULCERATIVE COLITIS AND CROHN'S DISEASE IN CHILDREN

Cover Page


Cite item

Full Text

Abstract

Relevance of research. Inflammatory bowel diseases are among the most severe pathologies in pediatric gastroenterology, often lead to disability. Despite the similarity of the clinic, pathogenetic mechanisms, the question of the differential diagnosis of ulcerative colitis and Crohn's disease is relevant in view of their different prognosis and treatment strategy. In recent years, in medical uses infrared spectroscopy of blood serum for the differential diagnosis of various inflammatory diseases, benign and malignant tumors. Besides finding increasing application of mathematical methods for data processing, the so-called mathematical modeling of pathological processes, allowing objectify the survey results for a more accurate diagnosis and prognosis of pathological processes. Objective: improving the differential diagnosis of ulcerative colitis and Crohn's disease in children. Patients: 21 children with ulcerative colitis, 56 children with Crohn's disease and 34 healthy children. The method of infrared spectroscopy of serum and mathematical modeling results through multivariate entropy analysis. Results: the obtained spectral characteristics of blood serum in children with ulcerative colitis and Crohn's disease and in healthy children, as well as "images of disease" in these pathologies. Conclusion: The use of this medical technology reduced the time of diagnosis, which contributes to the timely choice of rational treatment strategies and provides an opportunity to avoid the development of complications, worsening of the disease.

 

About the authors

E. N. Fedulova

Nizhny Novgorod Research Institute of Pediatric Gastroenterology, Russian Federation

Author for correspondence.
Email: fedulova04@mail.ru
MD, Head of the Department of Clinic of Colon Pathology of FSBI “Nizhnii Novgorod Research Institute of Pediatric Gastroenterology” of Ministry of Health, Russian Federation. Address: 22, Semashko Street, Nizhny Novgorod, RF, 603950; tel.: +7 (831) 436-67-06 Russian Federation

A. S. Gordetsov

Nizhny Novgorod State Medical Academy Russian Federation

Email: chem@gma.nnov.ru
PhD, professor, Head of the Department of General Chemistry of SBEI HPE “Nizhnii Novgorod State Medical University” of Ministry of Health, Russian Federation. Address: 190a, Rodionov Street, Nizhny Novgorod, RF, 603093; tel.: +7 (831) 438-80-05 Russian Federation

O. V. Fedorova

Nizhny Novgorod Research Institute of Pediatric Gastroenterology, Russian Federation

Email: olgafedorva@mail.ru
senior research scientist of Clinic of Colon Pathology of FSBI “Nizhnii Novgorod Research Institute of Pediatric Gastroenterology” of Ministry of Health, Russian Federation. Address: 22, Semashko Street, Nizhny Novgorod, RF, 603950; tel.: +7 (831) 436-67-06 Russian Federation

L. V. Korkotashvili

Nizhny Novgorod Research Institute of Pediatric Gastroenterology, Russian Federation

Email: niidetgastro@mail.ru
MD, Head of Laboratorial and Diagnostic Department of FSBI “Nizhnii Novgorod Research Institute of Pediatric Gastroenterology” of Ministry of Health, Russian Federation. Address: 22, Semashko Street, Nizhny Novgorod, RF, 603950; tel.: +7 (831) 436-54-60 Russian Federation

O. A. Tutina

Nizhny Novgorod Research Institute of Pediatric Gastroenterology, Russian Federation

Email: tutina_oa@mail.ru
MD, research scientist of Clinic of Colon Pathology of FSBI “Nizhnii Novgorod Research Institute of Pediatric Gastroenterology” of Ministry of Health, Russian Federation. Address: 22, Semashko Street, Nizhny Novgorod, RF, 603950; tel.: +7 (831) 436-67-06 Russian Federation

References

  1. Belousova E.A. Yazvennyi kolit i bolezn' Krona [Ulcerative Colitis and Crohn's Disease]. Tver, Triada. 2002. 128 p.
  2. Adler G. Bolezn' Krona i yazvennyi kolit. Per. s nem. A. A. Sheptulina [Crohn's Disease and Ulcerative Colitis. Translated from German by A.A. Sheptulin]. Moscow, GEOTАR-med, 2001. 500 p.
  3. Berens R. Bolezn' Krona i yazvennyi kolit detei i podrostkov. Prakticheskoe rukovodstvo. Per. s nem. A Sheptulin, S. Sitkin [Crohn's Disease and Ulcerative Colitis in Children and Adolescent. Manual. Translated from German by A.A. Sheptulin, S. Sitkin]. Germany, DR FALK PHARMA GmbH, 2005. 48 p.
  4. Grigor'eva G.A., Meshalkina N.Yu. Bolezn' Krona [Crohn's Disease]. Moscow, Meditsina, 2007. 184 p.
  5. Mazankova L.N., Khalif I.L., Vodilova O.V. Bolezn' Krona u detei: printsipy diagnostiki i lecheniya [Crohn's Disease in Children: Principles of Diagnosis and Treatment]. Moscow, MEDpress inform, 2008. 96 p.
  6. Baranov A.A., Potapov A.S., Tsimbalova E.G. Vestnik RAMN = Annals of the Russian Academy of Medical Sciences. 2011; 6: 36–41.
  7. Turner D., Levine A., Escher J.C., Griffiths A.M., Russell R.K., Dignass A., Dias J.A., Bronsky J., Braegger C.P., Cucchiara S., de Ridder L., Fageberg U.L., Hussey S., Hugot J-P., Kolacek S., Kolho K.L., Lionetti P., Poerrigaard A., Potapov A., Rintala R., Serban D.E., Staianj A., Sweeny B., Veerman G., Veres G., Wilson D.C. and Ruemmell F.M. Management of pediatric ulcerative colitis: joint ECCO and ESPGHAN evidence-based consensus guidelines. JPGN. 2012; 55 (3): 340-361.
  8. Shih D.Q., Targan S.R., Govern D. Recent advances in IBD pathogenesis: genetics and immunobiology. Curr. Gastroenterol. Rep. 2008; 10: 568-575.
  9. Abraham C., Cho J.H. Inflammatory bowel disease N. Engl. J. Med., 2009; 361: 2066-2078.
  10. Vorob'ev G.I., Khalif I.L. Vospalitel'nye zabolevaniya kishechnika [Inflammatory Diseases of Intestine]. Moscow, Miklosh, 2008. 424 p.
  11. Krasnikova O.V. Fiziologicheskii analiz infrakrasnykh spektrov plazmy krovi zhivotnykh v norme i pri eksperimental'nom onkogeneze. Avtoref. dis. …kand. med. nauk [Physiological Analysis of Infra-red Spectrum of Animals’ Blood Plasma in Norm and in Experimental Ontogenesis. Author’s abstract]. Nizhny Novgorod, 2012. 25 p.
  12. Gordetsov A.S. Sovr. med. tekhnologii = Current medical technologies. 2010; 1: 84–98.
  13. Yazykova A.B., Korkotashvili L.V., Kolesov S.A., Fedulova E.N., Fedorova O.V. Vrach-aspirant – Postgraduate physician. 2012; 3.4 (52): 563–571.
  14. Fatkullina I.B., Protopopova N.V., Mikhalevich I.M. Vestn. novykh meditsinskikh tekhnologii = Bulletin of current medical technologies. 2011; 18 (1): 134.
  15. Bezlyak V.V., Kovalev I.A., Plotnikova I.V. Pediatriya = Pediatrics. 2010; 89(3): 39–45.
  16. Fedulova E.N., Gordetsov A.S., Tutina O.A., Lebedev A.V. Patent № 2366956 RF, MPK G01N 33/52. Sposob differentsial'noi diagnostiki nespetsificheskogo yazvennogo kolita i bolezni Krona u detei. Nizhegorodskii NII gastroenterologii Rosmedtekhnologii. № 2007126007/15. Zayav. 09.07.2007. Opubl. 10.09.2009. Byul. № 25 [Method of Differential Diagnostics of Unspecific Ulcerative Colitis and Crohn’s Disease in Children. Nizhnii Novgorod Research Institute of Gastroenterology, Rosmedtechnologies. № 2007126007/15. Patent application 09.07.2007. Published 10.09.2009. Bulletin № 25]. Nizhny Novgorod, 2009.
  17. Nasonov S.V., Ignat'ev A.A. etc. Svidetel'stvo ob ofitsial'noi registratsii programmy dlya EVM № 2007611453. Programma dlya obrabotki i sozdaniya ekspertnykh diagnosticheckikh sistem DiaStat [Certificate on Official Registration of Computer Program № 2007611453. Program for Processing and Creation of Expert-diagnostical Systems DiaStat].

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 1970 "Paediatrician" Publishers LLC



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies