CORTISOL LEVELS IN CORD BLOOD WITH VARIOUS VIOLATIONS OF NEONATAL ADAPTATION

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Abstract

Shifting extra uterine existence is a serious test of maturity of all functional systems of the newborn , so in recent years, the more attention is payed for the adaptation of the newborn. It is known that the pathological course of pregnancy is a violation of the functional state of the adrenal cortex, and prolonged exposure of the pathological factor leads to the inhibition of adrenocortical function and a decrease of the adaptive capabilities of a newborn. Therefore, serum cortisol levels could be a predictor of complications in preterm infants. Based on this, it seems appropriate to study changes in the content of serum cortisol cord blood prior to the development of various syndromes neonatal maladjustment. The clinical and laboratory examination of term infants with various disorders of adaptation: regurgitation, pain, hyperexcitability , depression , cardio - respiratory depression, bleeding in the skin , toxic erythema. It is shown that the most prominent violations maladjustment processes occur on the background of decreased cortisol. Border states, which are formed on the background of normal or elevated cortisol, are not accompanied by significant impairments of adaptation processes . On the basis of the data was drawn a conclusion about the possibility of using changes of cortisol in cord blood as a reliable indicator of neonatal adaptation processes, pointing to the possibility of the development of pathological conditions.

 

About the authors

N. I. Kolesnikova

Research Centre for Problems of Family Health and Human Reproduction of Siberian Branch of RAMS, Chelyabinsk, Russian Federation

Author for correspondence.
Email: iphr@sbamsr.irk.ru
PhD, professor, corresponding member of RAMS, Director of Scientific Center of Family Health Aspects and Human Reproduction of Siberian Department of RAMS. Address: 16, Timiryazev Street, Irkutsk, RF, 664003; tel.: +7 (3952) 20-76-36 Russian Federation

A. S. Popova

Chelyabinsk city hospital № 6, Russian Federation

Email: biochem2009@yandex.ru
MD, Head of Gynecology Department № 2 of Municipal Heaslthcare Institution № 6 of Chelyabinsk. Address: 28, Rumyantsev Street, Chelyabinsk, RF, 454047; tel.: +7 (351) 721-25-65 Russian Federation

A. I. Sinitskii

South Ural State Medical University, Chelyabinsk, Russian Federation

Email: biochem2009@yandex.ru
MD, senior lecturer of the Department of Biochemistry of SBEI HPE “South-Ural State Medical University” of Ministry of Health, Russian Federation. Address: 64, Vorovskogo Street, Chelyabinsk, RF, 454092; tel.: +7 (351) 232-74-76 Russian Federation

D. A. Kozochkin

South Ural State Medical University, Chelyabinsk, Russian Federation

Email: biochem2009@yandex.ru
MD, lecturer of the Department of Biochemistry of SBEI HPE “South-Ural State Medical University” of Ministry of Health, Russian Federation. Address: 64, Vorovskogo Street, Chelyabinsk, RF, 454092; tel.: +7 (351) 232-74-76 Russian Federation

A. B. Gornostaeva

South Ural State Medical University, Chelyabinsk, Russian Federation

Email: biochem2009@yandex.ru
MD, senior lecturer of the Department of Biochemistry of SBEI HPE “South-Ural State Medical University” of Ministry of Health, Russian Federation. Address: 64, Vorovskogo Street, Chelyabinsk, RF, 454092; tel.: +7 (351) 232-74-76 Russian Federation

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