Microvesicles of leukocyte origin

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Abstract

Microvesicles are a new field of biological research. They are subcellular structures ranging in size from 100 to 1000 nm and found in practically all human biological fluids. Their sources are different cells. Microvesicles have a diverse internal composition and carry a wide spectrum of molecules on their surface, which determines their participation in physiological and pathological processes. Their assumed role of biological markers of diseases has aroused great interest. At the present time, there is a lot of data in the world literature about microvesicles of platelets and endothelial cells, and there is practically no data about microvesicles of leukocytes. In this regard, the purpose of the given review was to summarize the data about microvesicles of leukocytes. The review presents data about source cells, internal and superficial composition of leukocytes’ microvesicles, their interaction with various cells, and involvement in physiological and pathological processes. Further study of microvesicles will make it possible to clarify their role in normal and pathological conditions, the possibility of using them as vectors of diseases and carriers of various biologically active molecules.

About the authors

Kseniya L. Markova

The Research Institute of Obstetrics, Ginecology and Reproductology named after D.O. Ott

Email: kseniyabelyakova129@gmail.com
ORCID iD: 0000-0003-2748-3543

Junior research, Cell Interactions Laboratory, Department of Immunology and Cell Interactions.

Saint-Petersburg

 

SPIN ID: 4917-8153

Russian Federation

Igor U. Kogan

The Research Institute of Obstetrics, Ginecology and Reproductology named after D.O. Ott

Email: ikogan@mail.ru
ORCID iD: 0000-0002-7351-6900

Professor, MD, corresponding member of the RAS, temporarily assuming the responsibilities of the director.

Saint-Petersburg

SPIN-код: 6572-6450

 

Russian Federation

Anastasia R. Sheveleva

The Research Institute of Obstetrics, Ginecology and Reproductology named after D.O. Ott

Email: anastasiasheveleva075@gmail.com
ORCID iD: 0000-0003-2126-880X

Researcher, Cell Interactions Laboratory, Department of Immunology and Cell Interactions.

 Saint-Petersburg

SPIN ID:1741-9092 

Russian Federation

Valentina A. Mikhailova

The Research Institute of Obstetrics, Ginecology and Reproductology named after D.O. Ott

Email: mva_spb@mail.ru
ORCID iD: 0000-0003-1328-8157

Senior researcher, Cell Interactions Laboratory, Department of Immunology and Cell Interactions, PhD.

SPINID: 1749-5100

 

 

Saint-Petersburg

 

 

Russian Federation

Sergey A. Selkov

The Research Institute of Obstetrics, Ginecology and Reproductology named after D.O. Ott

Email: selkovsa@mail.ru
ORCID iD: 0000-0003-1560-7529

Professor, MD, Head of Immunology and Cell Interactions Department.

Saint-Petersburg

SPIN ID: 7665-0594

 

Russian Federation

Dmitry I. Sokolov

The Research Institute of Obstetrics, Ginecology and Reproductology named after D.O. Ott

Author for correspondence.
Email: falcojugger@yandex.ru
ORCID iD: 0000-0002-5749-2531

Doctor of Biological Sciences, Head of Cell Interactions Laboratory.

3, Mendeleyevskaya line, 199034 Saint-Petersburg

 

SPIN ID: 3746-0000

Russian Federation

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