ENDOTHELIAL PROTECTION DRUGS ― A NEW CLASS OF PHARMACOLOGICAL AGENTS

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Abstract

This review considers issues dealing with the role of nitric oxide and endothelial function/dysfunction in providing a number of physiological and pathophysiological processes and various body systems functioning. It also covers in details the possible ways of pharmacological management of endothelial dysfunction (ED) using drugs of different pharmacological groups (classes). Diverse pharmacological effects which have various degree of intensity and presented at various stages of ED pathogenesis are discussed. The value and urgency of search and development of agents with endothelial protection potential are studied in available experimental and clinical works on the considerable role of endothelial system in cardiovascular diseases and lack of specific means for prevention and treatment of endothelial dysfunction. Integrated morphological-functional approach to assessment of ED and endothelial protection of substances was developed and implemented in experimental practice in Cardiovascular Agents Laboratory of the Volgograd State Medical University Research Institute of Pharmacology. Various ED models were tested and most valid ones were selected. Еndothelial protection of new compounds such as Salifen and Flavicin are considered and compared with cardiovascular drugs, antioxidants with metabolic effects, GABA derivatives. These drugs are assumed to belong to a new class of drugs – endothelial protection drugs.

 

About the authors

I. N. Tyurenkov

Volgograd State Medical University, Department of Pharmacology and Biopharmaceutics
Cardiovascular Agents Laboratory of the Research Institute of Pharmacology

Author for correspondence.
Email: fibfuv@mail.ru
член-корреспондент РАМН, профессор, заведующий кафедрой фармакологии и био- фармации ФУВ ГБОУ ВПО ВолгГМУ Минздравсоцразвития России, заведующий лабораторией фармакологии сердечно-сосудистых средств НИИ фармакологии ГБОУ ВПО ВолгГМУ Минздравсоцразвития России Адрес: 400001, Волгоград, ул. Пугачевская, д. 3 Тел./факс: (8442) 97-81-80 Russian Federation

A. V. Voronkov

Cardiovascular Agents Laboratory of the Research Institute of Pharmacology

Email: prohor77@mail.ru
доктор медицинских наук, старший научный сотрудник лаборатории фармакологии сердечно-сосудистых средств НИИ фармакологии ГБОУ ВПО ВолгГМУ Минздравсоцразвития России Адрес: 400001, Волгоград, ул. Пугачевская, д. 3 Тел./факс: (8442) 97-81-80 Russian Federation

A. A. Slietsans

Cardiovascular Agents Laboratory of the Research Institute of Pharmacology

Email: fibfuv@mail.ru
кандидат фармацевтических наук, научный сотрудник лаборатории фармакологии сердечно-сосудистых средств НИИ фармакологии ГБОУ ВПО ВолгГМУ Минздравсоцразвития России Адрес: 400001, Волгоград, ул. Пугачевская, д. 3 Тел./факс: (8442) 97-81-80 Russian Federation

E. V. Volotova

Volgograd State Medical University, Department of Pharmacology and Biopharmaceutics

Email: fibfuv@mail.ru
кандидат медицинских наук, ассистент кафедры фармакологии и биофармации ФУВ ГБОУ ВПО ВолгГМУ Минздравсоцразвития России Адрес: 400001, Волгоград, ул. Пугачевская, д. 3 Тел./факс: (8442) 97-81-80 E-mail: a-zlato@mail.ru Russian Federation

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