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The erection is very immediate in the non-ED patient as the frontal cortex talks with the penis quickly. The go-between is CGMP - cyclic guanosine monophosphate. The erection is very frustrated in light of the fact that the correspondence between the frontal cortex and the penis gets decimated. ED patients have PDE5 synthetic substances, which reduce the CGMP level making it difficult for the brain to respond to the sexual affectation.