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These mechanisms that reduce hunger are: the suppression of orexigenic peptides, the increase in energy expenditure, by activating basal metabolism and body temperature (thus burning energy reserves), the reduction of lipogenesis (the formation of new fats), activation of lipolysis of triglycerides and beta oxidation of the resulting fatty acids. The functioning of leptin is actually negative feedback, that is, when the hypothalamus detects enough fat reserves, it inhibits intake and anabolism (the formation of new ones) and activates catabolism (the metabolization of existing ones to produce energy). Reviews of Leptoconnect