The article concerns the 100th anniversary of the Department of Propaedeutics of Internal Diseases at the NN Burdenko Voronezh State Medical University. There are several important stages in the formation of the department. The history of the development of the department of propaedeutics of internal diseases is inextricably linked with the formation of the Voronezh Medical University from the day of its foundation. During the last century, the department was headed by famous scientists-clinicians: Philosophov P.I., Kurshakov N.A., Gerke A.A., Ravich-Shcherbo V.A., and others. The national medicine owes to their work in the field of diagnosis and treatment of tuberculosis diseases of the lungs and pleura, the clinical course of adhesive pericarditis. During the postwar periods, the department was headed by professors Tumanovsky M.N., Kobyzev A.S., Safonov Yu.D. Their contribution to the development of medical science is difficult to overestimate. The doctrine of Professor Safonov Yu.D. on the bio-hydraulic mechanism of origin of heart sounds found resonance all over the world. Since 1987 to the present time the department of propaedeutics of internal diseases is headed by Professor Nikitin A.V. known as the founder of a new scientific direction in the field of non-drug treatment methods for diseases of internal organs. For his scientific contribution, Anatoly Vladimirovich was awarded the USSR Council of Ministers Prize, and was given an Honorary title «Honored Worker of the Higher School of the Russian Federation». Professor Nikitin A.V. is a famous scientist, a clinician, and a teacher who advised on 50 candidate and 5 doctoral dissertations defended afterward.