Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC85610.15690/vramn856ENDOCRINOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ЭНДОКРИНОЛОГИИMICRORNA: ROLE IN GH-SECRETING PITUITARY ADENOMA PATHOGENESISМИКРОРНК И ИХ ЗНАЧЕНИЕ В ПАТОГЕНЕЗЕ СТГ-ПРОДУЦИРУЮЩИХ АДЕНОМ ГИПОФИЗАhttps://orcid.org/0000-0002-9314-7831LutsenkoA. S.ЛуценкоАлександр Сергеевич
Russian Federation

Moscow

Научный сотрудник отделения нейроэндокринологии и остеопатий

117036, Москва, ул. Дмитрия Ульянова, д. 11, тел.: +7 (495) 668-20-79 доб. 54-06.

SPIN-код: 4037-1030

some91@mail.ruhttps://orcid.org/0000-0002-6674-6441BelayaZ. E.БелаяЖанна Евгеньевна
Russian Federation

Moscow

Доктор медицинских наук, заведующая отделением нейроэндокринологии и остеопатий.

117036, Москва, ул. Дмитрия Ульянова, д. 11, тел.: +7 (495) 668-20-79 доб. 54-06.

SPIN-код: 4746-7173

jannabelaya@gmail.comhttps://orcid.org/0000-0001-9119-2447PrzhiyalkovskayaE. G.ПржиялковскаяЕлена Георгиевна
Russian Federation

Moscow

Кандидат медицинских наук, старший научный сотрудник отделения нейроэндокринологии и остеопатий.

117036, Москва, ул. Дмитрия Ульянова, д. 11, тел.: +7 (495) 668-20-79 доб. 54-06.

SPIN-код: 9309-3256

przhiyalkovskaya.elena@gmail.comhttps://orcid.org/0000-0002-5634-7877Mel'nichenkoG. A.МельниченкоГалина Афанасьевна
Russian Federation

Moscow

Доктор медицинских наук, профессор, академик РАН, директор Института клинической эндокринологии.

117036, Москва, ул. Дмитрия Ульянова, д. 11, тел.: +7 (499) 124-58-32.

SPIN-код: 8615-0038

teofrast2000@mail.ruEndocrinology Research CentreЭндокринологический научный центр180920177242902980506201707072017Copyright ©; 2017, "Paediatrician" Publishers LLCCopyright ©; 2017, Издательство "Педиатръ"2017"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/856

MicroRNA presents small (19–25 nucleotides long) non-coding RNA molecules which regulate gene expression on post-transcriptional level. Numerous studies revealed microRNA’s important role in physiological processes. Moreover, its aberrant expression has been described in many pathological conditions including pituitary tumors. Pituitary adenomas are benign intracranial tumors with various clinical presentations depending on the type of hormone secretion. Prediction of the pituitary adenoma aggressive level and treatment response is challenging due to the lack of reliable clinical predictors or non-invasive biomarkers. MicroRNAs in body fluids could potentially be a minimally invasive biomarker for tumor diagnosis and a predictor of treatment response and prognosis. Some studies reveal that microRNA is specific for a different pituitary adenoma subtypes. In the article, we review existing evidence on microRNA expression in GH-secreting tumors and its possible involvement in pathogenesis of somatotroph tumors.

МикроРНК — это малые некодирующие молекулы РНК, состоящие из 19–25 нуклеотидов, которые осуществляют регуляцию экспрессии генов путем воздействия на матричную РНК. В настоящее время появляется все больше данных о вкладе микроРНК в патогенез различных заболеваний, особенно опухолевых. Изменения в их экспрессии отмечаются при многих патологических состояниях, а устойчивость внеклеточных микроРНК к внешним воздействиям делает их перспективными кандидатами для использования в качестве биомаркеров. Аденомы гипофиза являются частыми интракраниальными образованиями, клиническая картина которых разнообразна и зависит от гормональной активности и особенностей роста опухоли. На дооперативном этапе спрогнозировать агрессивность течения заболевания и оценить возможность применения консервативного лечения бывает тяжело в связи с отсутствием неинвазивных опухолевых биомаркеров. Опубликовано большое количество исследований, посвященных экспрессии микроРНК в аденомах гипофиза с различной гормональной активностью и их связи с патогенетическими механизмами, что отражает интерес к данной области. В данном обзоре подробно рассмотрены результаты исследований по экспрессии микроРНК в СТГ-продуцирующих аденомах гипофиза и их возможная роль в патогенезе акромегалии.

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