Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC80610.15690/vramn806PEDIATRICS: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ПЕДИАТРИИCHALLENGES OF MOLECULAR-BASED DIAGNOSIS DEVELOPMENTAL DYSPLASIA OF THE HIP IN CHILDHOODПЕРСПЕКТИВЫ МОЛЕКУЛЯРНОЙ ДИАГНОСТИКИ ДИСПЛАЗИИ ТАЗОБЕДРЕННЫХ СУСТАВОВ У ДЕТЕЙhttps://orcid.org/0000-0002-4375-0405SertakovaA. V.СертаковаАнастасия Владимировна
Russian Federation

Sertakova Anastasiia Vladimirovna

Кандидат медицинских наук, врач травматолог-ортопед отдела организационно-методической и научно-образовательной деятельности НИИТОН.

410002, Саратов, ул. Чернышевского д. 148, тел.: +7 (452) 39-31-99.

SPIN-код: 8243-8811

anastasiya-sertakova@yandex.ruVladimirovnaO. L.МорозоваОльга Леонидовна
Russian Federation

Vladimirovna Olga Leonidovna

Доктор медицинских наук, профессор кафедры патофизиологии.

119435, Москва, ул. Большая Пироговская, д. 2, стр. 4.

SPIN-код: 1567-4113

morozova_ol@list.ruRubashkinS. A.РубашкинСергей Анатольевич
Russian Federation

Rubashkin Sergey Anatolevich

Кандидат медицинских наук, врач травматолог-ортопед отделения детской ортопедии НИИТОН.

410002, Саратов, ул. Чернышевского д. 148, тел.: +7 (452) 39-30-71.

SPIN-код: 8243-8811

docs@mail.ruTimaevM. Ch.ТимаевМуса Хамзатович
Russian Federation

Timaev Musa Chamzatovich

Врач травматолог-ортопед отделения детской ортопедии НИИТОН.

410002, Саратов, ул. Чернышевского д. 148, тел.: +7 (452) 39-30-71.

SPIN-код: 7796-3876

mustim@mail.ruNorkinI. A.НоркинИгорь Алексеевич
Russian Federation

Norkin Igor Alekseevich

Доктор медицинских наук, профессор, директор НИИТОН.

410002, Саратов, ул. Чернышевского д. 148, тел.: +7 (452) 39-31-91.

SPIN-код: 9253-7993

norkin@sarniito.comSaratov State Medical University n.a. V.I. RazumovskyСаратовский государственный медицинский университет им. В.И. РазумовскогоI.M.Sechenov First Moscow State Medical UniversityПервый Московский государственный медицинский университет им. И.М. Сеченова150720177231952022802201725052017Copyright ©; 2017, "Paediatrician" Publishers LLCCopyright ©; 2017, Издательство "Педиатръ"2017"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/806

Developmental dysplasia of the hip (DDH) is a vital and most frequently diagnosed disorder in pediatricrequiring developement and implementation of new diagnostic methods because of failure in detection of early dysplastic changes. Limitation in applying the diagnostic instrumental methods in infants and lack of uniform standards of clinical practice and management results in the increase in treatment cost and duration of rehabilitation. The purpose of this study was the search for new sensitive methods of diagnostics and treatment of DDH and profound study of pathogenic mechanisms. Despite the great attention of international pediatric specialists to the problem of DDH in children, the methods for early diagnostics, prevention of severe forms and complications are not still developed. The current study identifies the molecular mechanisms of DDH pathology and analyses the opportunities of instrumental and non-instrumental methods for its diagnosis. The authors presented the promising biomarkers and cytokines for the diagnosis and prediction of DDH.

Дисплазия тазобедренных суставов является наиболее частой формой патологии в детской ортопедии, требующей поиска новых методов диагностики в связи со сложностью раннего распознавания начальных диспластических изменений. Ограниченность использования диагностических инструментальных методов у детей раннего возраста, отсутствие единых стандартов лечебной тактики в пределах схожей клиники приводит к увеличению затрат на лечение пациента и продолжительности реабилитации. Несмотря на большое внимание специалистов к проблеме дисплазии тазобедренных суставов в детском возрасте, до настоящего времени не разработаны методы ее ранней диагностики, профилактики развития тяжелых форм и осложнений. В данном обзоре освещены молекулярные механизмы формирования патологии. Рассмотрены возможности инструментальных и молекулярных методов ее диагностики. Уделено внимание потенциальным биомаркерам и цитокинам, которые могут быть использованы для диагностики и прогнозирования течения заболевания.

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