Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC77910.15690/vramn779ENDOCRINOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ЭНДОКРИНОЛОГИИProspects for the Use of Cannabinoid Receptor Ligands for the Treatment of Metabolic Syndrome and Atherosclerosis: Analysis of Experimental and Clinical DataПерспективы использования лигандов каннабиноидных рецепторов для лечения метаболического синдрома и атеросклероза: анализ экспериментальных и клинических данныхhttps://orcid.org/0000-0002-6020-1598MaslovL. N.МасловЛеонид Николаевич
Russian Federation

Доктор медицинских наук, профессор, руководитель лаборатории экспериментальной кардиологии Научно-исследовательского института кардиологии.

Адрес: 634012, Томск, ул. Киевская, д. 111А.

SPIN-код: 5843-2490

maslov@cardio-tomsk.ruhttps://orcid.org/0000-0002-7011-4316KarpovR. S.КарповРостислав Сергеевич

Доктор медицинских наук, профессор, академик РАН, научный руководитель Научно-исследовательского института кардиологии.

Адрес: 634012, Томск, ул. Киевская, д. 111А.

SPIN-код: 8263-2641

tvk@cardio-tomsk.ruTomsk National Research Medical Centre, Russian Academy of SciencesТомский национальный исследовательский медицинский центр Российской академии наук0803201772159651012201627012017Copyright ©; 2017, "Paediatrician" Publishers LLCCopyright ©; 2017, Издательство "Педиатръ"2017"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/779

An antagonist of central cannabinoid CB1 receptors rimonabant causes weight loss in patients with obesity and metabolic syndrome, improves blood lipid parameters, increases the adiponectin level, decreases the rate of glucose and glycosylated hemoglobin in patients with diabetes mellitustype-2. However, rimonabant adverse effects include depression, anxiety, nausea, and dizziness which are apparently due to the blockade of central CB1 receptors. In mice with a high-calorie diet, we defined that the blockade of peripheral CB1 receptors prevents obesity, steatosis of the liver, improves lipid and carbohydrate metabolism. Experimental studies suggest that peripheral CB2 receptor agonists have antiatherogenic effect. To validate the expediency of clinical research of CB2 receptor agonists in patients with atherosclerosis the comparative analysis of antiatherogenic properties of cannabinoids should be performed. In addition, experiments are needed on the combination use of cannabinoids with well-known antiatherogenic agents, such as statins.

Антагонист центральных каннабиноидных СВ1-рецепторов римонабант вызывает снижение массы тела у пациентов с ожирением и метаболическим синдромом, улучшает липидные показатели крови, увеличивает уровень адипонектина, снижает уровень гликилированного гемоглобина и глюкозы у пациентов с сахарным диабетом 2-типа. Однако римонабант способствует возникновению депрессии, беспокойства, тошноты и головокружения, по-видимому, за счёт блокады центральных СВ1-рецепторов. Установлено, что у мышей, находящихся на высококалорийной диете, блокада периферических СВ1-рецепторов препятствует ожирению, стеатозу печени, улучшает показатели липидного и углеводного обмена. Экспериментальные исследования свидетельствуют, что агонисты периферических СВ2-рецепторов оказывают антиатерогенный эффект. Однако для решения вопроса о целесообразности клинических испытаний агонистов СВ2-рецепторов у пациентов с атеросклерозом необходим сравнительный анализ антиатерогенных свойств каннабиноидов. Кроме того, необходимы эксперименты по совместному применению каннабиноидов и известных антиатерогенных препаратов, например, статинов.

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