Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC77110.15690/vramn771CELL TRANSPLANTOLOGY AND TISSUE ENGINEERING: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ КЛЕТОЧНОЙ ТРАНСПЛАНТОЛОГИИ И ТКАНЕВОЙ ИНЖЕНЕРИИUrethra Reconstruction with Tissue-Engineering TechnologyРеконструкция уретры с помощью технологий тканевой инженерии.https://orcid.org/0000-0003-0594-7423VasyutinI. A.ВасютинИгорь Алексеевич
Russian Federation

Аспирант кафедры гистологии, цитологии и эмбриологии лечебного факультета, младший научный сотрудник Института регенеративной медицины.

Адрес: 119991, Москва, ул. Трубецкая, д. 8, стр. 2.

SPIN-код: 1872-8347

ivasyutin@yahoo.comhttps://orcid.org/0000-0002-0102-5491LyundupA. V.ЛюндупАлексей Валерьевич

Кандидат медицинских наук, заведующий отделом передовых клеточных технологий Института регенеративной медицины.

Адрес: 119991, Москва, ул. Трубецкая, д. 8, стр. 2

SPIN-код: 4954-3004

lyundup@gmail.comhttps://orcid.org/0000-0001-9510-9487VinarovA. Z.ВинаровАндрей Зиновьевич

Доктор медицинских наук, профессор, главный научный сотрудник НИИ уронефрологии и репродуктивного здоровья человека.

Адрес: 119435, Москва, ул. Большая Пироговская, д. 2, стр. 1.

SPIN-код: 5174-2233

avinarov@mail.ruhttps://orcid.org/0000-0003-2173-0566ButnaruD. V.БутнаруДенис Викторович

Кандидат медицинских наук, директор Института регенеративной медицины.

Адрес: 119991, Москва, ул. Трубецкая, д. 8, стр. 2.

SPIN-код: 2408-5133

butnaru_dv@mail.ruhttps://orcid.org/0000-0002-0704-1660KuznetsovS. L.КузнецовСергей Львович

Доктор медицинских наук, профессор, член-корр. РАН, заведующий кафедрой гистологии, цитологии и эмбриологии лечебного факультета.

Адрес: 125009, Москва, ул. Моховая, д. 11, стр. 3.

SPIN-код: 3824-2646

vakmedbiol@rambler.ruSechenov First Moscow State Medical UniversityПервый московский государственный медицинский университет имени И.М. СеченоваSechenov First Moscow State Medical UniversityПервый Московский государственный медицинский университет им. И.М. Сеченова0803201772117252411201614022017Copyright ©; 2017, "Paediatrician" Publishers LLCCopyright ©; 2017, Издательство "Педиатръ"2017"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/771

Urethral stricture is a disease characterized by a pathological narrowing of the urethra. Treatment for this condition often requires surgery using autologous grafts (urethroplasty). It is common practice to use patient’s own tissue like genital and extragenital skin, tunica vaginalis, buccal mucosa as a source of the graft. Alternative and safer approach is to use tissue-engineered graft created in a laboratory using patient’s autologous cells and biocompatible matrix (scaffold). The article presents the up-to-date achievements in lab-created tissue-engineered graft, describes all components needed to build a tissue-engineered structure of the graft for urethroplasty, and summarizes authors’ thoughts on advantages and disadvantages of various approaches to choose both cellular component and the matrix of future construction. The article reviews clinical studies conducted in the field of tissue engineering of the graft material for urethraplasty.

Стриктура уретры – заболевание характеризующиеся патологическим сужением мочеиспускательного канала. Лечение этого состояния зачастую требует хирургического вмешательства с использованием аутологичных графтов (трансплантатов) и лоскутов (уретропластика). Как правило, источниками графтов служат различные ткани самого пациента – генитальная и экстрагенитальная кожа, слизистая щеки, влагалищная оболочка яичка и др. Альтернативным, щадящим для пациента, подходом может быть использование технологии тканевой инженерии создания графта для уретропластики в лабораторных условиях с использованием аутологичных клеток пациента и биосовместимого матрикса (матрица, скаффолд, подложка). Данная статья описывает достижения тканевой инженерии в создании тканеинженерной конструкции уретры на сегодняшний день. В обзоре подробно рассказывается обо всех составных частях, необходимых для создания тканеинженерной конструкции уретры, описывается взгляд авторов на преимущества и недостатки различных альтернатив при выборе, как клеточного компонента, так и матрикса будущей конструкции. Представлен обзор доклинических и клинических исследований, проведенных в области тканевой инженерии уретры.

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