Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC6710.15690/vramn.v70i1.1227РATHOPHYSIOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ПАТОФИЗИОЛОГИИINFLAMMATION AND BRAIN AGINGВОСПАЛЕНИЕ И СТАРЕНИЕ МОЗГАSalminaA. B.СалминаА. Б.
Russian Federation

доктор медицинских наук, профессор, заведующая кафедрой биохимии с курсами медицинской, фармацевтической и токсикологической химии, проректор по инновационному развитию и международной деятельности КрасГМУ им. В.Ф. Войно-Ясенецкого Адрес: 660022, Красноярск, ул. П. Железняка, д. 1, тел.: +7 (391) 228-07-69

allasalmina@mail.ruKomlevaYu. K.КомлеваЮ. К.
Russian Federation

кандидат медицинских наук, ассистент кафедры биохимии с курсами медицинской, фармацевтической и токсикологической химии КрасГМУ им. В.Ф. Войно-Ясенецкого Адрес: 660022, Красноярск, ул. П. Железняка, д. 1, тел.: +7 (391) 228-07-69

yuliakomleva@mail.ruKuvachevaN. V.КувачеваН. В.
Russian Federation

кандидат фармацевтических наук, доцент кафедры биохимии с курсами медицинской, фармацевтической и токсикологической химии КрасГМУ им. В.Ф. Войно-Ясенецкого Адрес: 660022, Красноярск, ул. П. Железняка, д. 1, тел.: +7 (391) 228-07-69

natalya.kuvacheva@gmail.ruLopatinaO. L.ЛопатинаО. Л.

кандидат биологических наук, доцент кафедры биохимии с курсами медицинской, фармацевтической и токсикологической химии КрасГМУ им. В.Ф. Войно-Ясенецкого Адрес: 660022, Красноярск, ул. П. Железняка, д. 1, тел.: +7 (391) 228-07-69

ol.lopatina@gmail.comPozhilenkovaE. A.ПожиленковаЕ. А.
Russian Federation

кандидат биологических наук, доцент кафедры биохимии с курсами медицинской, фармацевтической и токсикологической химии КрасГМУ им. В.Ф. Войно-Ясенецкого Адрес: 660022, Красноярск, ул. П. Железняка, д. 1, тел.: +7 (391) 220-06-28

elena.a.pozhilenkova@gmail.comGorinaYa. V.ГоринаЯ. В.
Russian Federation

кандидат фармацевтических наук, доцент кафедры биохимии с курсами медицинской, фармацевтической и токсикологической химии КрасГМУ им. В.Ф. Войно-Ясенецкого Адрес: 660022, Красноярск, ул. П. Железняка, д. 1, тел.: +7 (391) 220-06-28

yana_20@bk.ruGasymlyE. D.ГасымлыЭ. Д.
Russian Federation

клинический ординатор кафедры нервных болезней, традиционной медицины с курсом последипломного образования КрасГМУ им. В.Ф. Войно-Ясенецкого Адрес: 660022, Красноярск, ул. П. Железняка, д. 1, тел.: +7 (391) 220-06-28

elya_qasimli@mail.ruPaninaYu. A.ПанинаЮ. А.
Russian Federation

аспирант кафедры биохимии с курсами медицинской, фармацевтической и токсикологической химии КрасГМУ им. В.Ф. Войно-Ясенецкого Адрес: 660022, Красноярск, ул. П. Железняка, д. 1, тел.: +7 (391) 220-06-28

elving-girl@list.ruMorgunA. V.МоргунА. В.
Russian Federation

кандидат медицинских наук, ассистент кафедры педиатрии ИПО КрасГМУ им. В.Ф. Войно-Ясенецкого Адрес: 660022, Красноярск, ул. П. Железняка, д. 1, тел.: +7 (391) 220-06-28

441682@mail.ruMalinovskayaN. A.МалиновскаяН. А.
Russian Federation

доктор медицинских наук, доцент кафедры биохимии с курсами медицинской, фармацевтической и токсикологической химии, научный сотрудник НИИ молекулярной медицины и патобиохимии КрасГМУ им. В.Ф. Войно-Ясенецкого Адрес: 660022, Красноярск, ул. П. Железняка, д. 1, тел.: +7 (391) 228-07-69

konsuelo81@mail.ruV.F. Voyno-Yasenetksy Krasnoyarsk State Medical University, Russian FederationКрасноярский государственный медицинский университет им. В.Ф. Войно-Ясенецкого, Российская Федерация28012015701Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук172507082015Copyright ©; 2015, "Paediatrician" Publishers LLCCopyright ©; 2015, Издательство "Педиатръ"2015"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/67

The review covers current concepts on cell and molecular mechanisms of neuroinflammation and aging with the special focus on the regulation of cytokine-producing activity of astroglial cells and intercellular communication. The review reflects that a key component of the aging phenomenon as a result of ineffective implementation of anti-inflammatory response are processes of the dysregulated cytokine production, in particular, an increase in the secretion of proinflammatory cytokines and an imbalance in the expression of the receptors and receptor associated proteins. Interpretation of the molecular mechanisms of cell conjugating neuroinflammation and aging cells can give rise to new therapeutic strategies that are relevant to the treatment of a wide range of central nervous system diseases and the development of new experimental models of diseases of the central nervous system.

Обсуждаются современные представления о клеточно-молекулярных механизмах нейровоспаления и старения, в частности, регуляции цитокин-продуцирующей активности клеток астроглиальной природы и реализации межклеточных взаимодействий. Ключевым компонентом феномена старения как результата неэффективной реализации противовоспалительного ответа являются процессы дизрегуляции продукции цитокинов, в частности, повышение интенсивности секреции провоспалительных цитокинов и дисбаланс в экспрессии соответствующих рецепторов и рецепторассоциированных белков. Расшифровка клеточных молекулярных механизмов, сопрягающих нейровоспаление и старение клеток, может дать начало новым терапевтическим стратегиям, актуальным для лечения широкого спектра заболеваний центральной нервной системы и разработки новых экспериментальных моделей заболеваний центральной нервной системы.

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