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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Annals of the Russian academy of medical sciences</journal-id><journal-title-group><journal-title xml:lang="en">Annals of the Russian academy of medical sciences</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российской академии медицинских наук</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0869-6047</issn><issn publication-format="electronic">2414-3545</issn><publisher><publisher-name xml:lang="en">"Paediatrician" Publishers LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">555</article-id><article-id pub-id-type="doi">10.15690/vramn.v70.i5.1449</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>SCIENTIFIC REPORTS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>НАУЧНЫЕ СООБЩЕНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Condition of State and Trait Anxiety in Pregnant Women with Fetal Malformations</article-title><trans-title-group xml:lang="ru"><trans-title>Состояние реактивной и личностной тревоги у беременных с пороками развития плода</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Khudaverdyan</surname><given-names>A. D.</given-names></name><name xml:lang="ru"><surname>Худавердян</surname><given-names>А. Д.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>кандидат медицинских наук, доцент кафедры акушерства и гинекологии № 2 Ереванского государственного медицинского университета им. М. Гераци Адрес: 0025, Ереван, Армения, ул. Корюна, д. 2, тел.: +374 (60) 62-12-21</p></bio><email>anna.khudaverdyan2@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Yerevan State Medical University n.a. M. Heratsi, Yerevan, Armenia</institution></aff><aff><institution xml:lang="ru">Ереванский государственный медицинский университет им. М. Гераци, Ереван, Республика Армения</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-12-03" publication-format="electronic"><day>03</day><month>12</month><year>2015</year></pub-date><volume>70</volume><issue>5</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>604</fpage><lpage>607</lpage><history><date date-type="received" iso-8601-date="2015-12-03"><day>03</day><month>12</month><year>2015</year></date><date date-type="accepted" iso-8601-date="2015-12-03"><day>03</day><month>12</month><year>2015</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, "Paediatrician" Publishers LLC</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, Издательство "Педиатръ"</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">"Paediatrician" Publishers LLC</copyright-holder><copyright-holder xml:lang="ru">Издательство "Педиатръ"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2016-12-03"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://vestnikramn.spr-journal.ru/jour/about/submissions</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnikramn.spr-journal.ru/jour/article/view/555">https://vestnikramn.spr-journal.ru/jour/article/view/555</self-uri><abstract xml:lang="en"><p><bold>Objective:</bold> Our aim was to assess the level of state and trait anxiety, and the level of tolerated stress in pregnant women with fetus malformations.</p><p><bold>Methods</bold>: A controllled non-randomized clinical study with sequential inclusion of participants was carried out. Psychoemotional status of pregnant women was assessed by Spielberger anxiety scale, with identification of state and trait anxiety, as well as on the basis of medical history data. Pregnant women were divided into 2 groups. Control group — 20 women with physiological gestation course without any fetus malformations and absence of stress situations in medical history. Main group — 40 women with fetus malformations, presence of long stressful situations in medical history, starting from early gestation period.</p><p><bold>Results</bold>: 60 women aged 20–37 years old, at the pregnancy age of 20–38 weeks were examined by ultrasound with assessment anatomy of the fetus. Comparative analysis of the psychological and emotional status of pregnant women from both groups indicated significant increase of the state and trait anxiety level in the main group of women compared to the control in the average grew from 30.80±1.47 to 48.13±3.84 (p &lt;0.001) and from 32.35±1.45 to 50.25±3.40 (p &lt;0.001) respectively.<bold> </bold></p><p><bold>Conclusion</bold>: The identified high level of state and trait anxiety in pregnant women with fetus malformations allows concluding that maternal stress is a potential risk factor for generation of intrauterine malformations of the fetus. This serves as a basis to recommend corresponding prophylactic, anti-stress measures should be taken during such pregnancy, especially at early stages, when fetus tissues formation process is taking place.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Цель исследования</bold>: оценить уровень реактивной и личностной тревоги, а, соответственно, и степень переносимого стресса у беременных с пороками развития плода.</p><p><bold>Методы</bold>: проведено контролируемое нерандомизированное клиническое исследование с последовательным включением участников в группы. Психоэмоциональный статус беременных оценивали по шкале Спилбергера с определением степени реактивной и личностной тревоги в баллах, а также на основании анамнестических данных. Беременные были разделены на 2 группы. Контрольная группа — 20 женщин с физиологическим течением беременности без каких-либо нарушений в развитии плода и отсутствием в анамнезе стрессовых ситуаций. Основная группа — 40 женщин с пороками развития плода, наличием в анамнезе длительных стрессовых ситуаций, начиная с ранних сроков развития беременности. При выборе исследуемых особое внимание обращали на отсутствие в процессе беременности тех или иных заболеваний.</p><p><bold>Результаты</bold>: проведено ультразвуковое обследование 60 женщин в возрасте от 20 до 37 (28,5±0,5) лет на сроке беременности 20–38 нед с оценкой анатомического строения плода. Сравнительный анализ состояния психоэмоционального статуса беременных обеих групп позволил установить значительное повышение процентных и абсолютных показателей уровня реактивной и личностной тревоги в основной группе женщин по сравнению с контрольной. По результатам статистической обработки данных уровни реактивной и личностной тревоги в основной группе женщин по сравнению с контрольной возросли с 30,80±1,47 до 48,13±3,84 (p &lt;0,001) и с 32,35±145 до 50,25±3,40 (p &lt;0,001) баллов, соответственно.</p><p><bold>Заключение</bold>: высокий уровень реактивной и личностной тревоги у беременных с пороками развития плода позволяет заключить, что материнский стресс является потенциальным фактором риска для возникновения внутриутробных пороков развития плода. Это является основанием для рекомендации соответствующих профилактических, антистрессовых мероприятий во время такой беременности, особенно на ее ранних стадиях, когда происходят процессы формирования тканей плода.</p></trans-abstract><kwd-group xml:lang="en"><kwd>state and trait anxiety</kwd><kwd>pregnancy</kwd><kwd>fetus</kwd><kwd>malformations</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>реактивная и личностная тревога</kwd><kwd>беременность</kwd><kwd>плод</kwd><kwd>пороки развития</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>1. Abramchenko V.V., Kovalenko N.V. Perinatal'naya psikhologiya, teoriya, metodologiya, opyt [Perinatal Psychology, Theory, Methodology, Experience]. St. Petersburg, Izd-vo S.-Pb. un-ta, 2001. 348 P.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>2. Tarabrina N.V. Praktikum po psikhologii posttravmaticheskogo stressa [Workshop on the Psychology of Post-traumatic Stress]. St. Petersburg, 2011. 272 p.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>3. Kovalenko N.P. Perinatal'naya psikhologiya [Perinatal Psychology]. St. Petersburg, Yuventa, 2000. 206 p.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>4. Khudaverdyan A.D., Saroyan M. Yu., Khudaverdyan D.N., Arutyunyan A.A. Influence of emotional stress on the content of adrenocorticotropic hormone and cortisol in the blood of pregnant rats and their offspring. Meditsinskaya nauka Armenii = Medical science in Armenia. 2014;4(3):3.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>5. Maina G., Saracco P., Giolito M.R., Danelon D., Bogetto F., Todros T. Impact of maternal psychological distress on fetal weight, premat and intrauterine growth retardation. J. Affect Disord. 2008; 111: 214–220.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>6. Abramchenko V.V. Psikhosomaticheskoe akusherstvo [Psychosomatic Obstetrics]. St. Petersburg, Sotis, 2001. 311 p.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>7. Varaksina G.N. Psikhovegetativnye izmeneniya u zhenshchin s nevynashivaniem beremennosti. Mat-ly Vserossiiskoi konferentsii [Psychovegetative Changes in Women with Miscarriage. Materials of the All-Russian Conference]. Ivanovo, 2001. P. 108.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>8. Kashina E.V. Kliniko-morfologicheskie osobennosti vrozhdennykh porokov razvitiya TsNS v ontogeneze u detei. Avtoref. dis… kand. med. nauk [Clinico-morphological Features of Congenital Malformations of the CNS in Ontogenesis of Children. Author’s abstract]. Khabarovsk, 2008. 28 p.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>9. Prenatal diagnosed anomalies of the central nervous system: the experience of ten years. Abstracts of the 20th World Congress on ultrasound in Obstetrics and Gynecology. C. Kari, N. Deole (eds.). 2010; 36 (Issue 1): 224–225.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>10. Zatikyan E.P. Coarctation of the aorta in the fetus. Accuracy and error diagnostics. Sono Ace – Ultra sound. 2013;25:17–21.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>11. Degtyarev Yu.G. Risk factors in the occurrence of congenital malformations. Meditsinskii zhurnal (Belarus') = Journal of Medicine (Belarus). 2014;2:4–10.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>12. Liang J.Z., Olsen J., Toft H.S., Jiong Li, Nohr E.A., Obel C., Vestergaard M. Prenatal maternal bereavement and congenital heart defects in off spring: A Registry Based Study. Pediatrics. 2013; 131 (4): 1225–1230.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>13. Spielberger C.D., Gorush R.I., Lushene R.E. STAI manual for the state trait anxiety inventory. Palo Alto, CA: Consulting Psycologists Press. 1970. Available at: http://hdl.handle.net/10477/2895 (accessed: 23.06.2015).</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>14. Glover V., Bergman K., Sarkar P., O’Connor T.G. Association between maternal and amniotic fluid cortisol is moderated by maternal anxiety. Psychoneuroendocrinology. 2009; 34 (3): 430–435.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>15. Sarkar P., Bergman K., Fisk N.M., Glover V. Maternal anxiety at amniocentesis and plasma cortisol. Prenat. Diagn. 2006; 26 (6):505–509.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>16. Carmichael S.L., Shaw G.M., Yang W., Abrams B., Lammer E.J. Maternal stressful events and risks of birth defects. Epidemiology. 2007; 18 (3): 356–361.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>17. Suarez L., Cardarelli K., Hendricks K. Maternal stress social support and risk of neural defects among Mexican Americans Epidemiology. Ann. Epidemiol. 2003; 13 (2): 81–88.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>18. Aznauryan A.V., Khudaverdyan A.D., Saroyan M.Yu., Abramyan R.A. Structural and functional characteristics of the placenta in the psycho-emotional stress. Eksperimental'naya i klinicheskaya meditsina = Experimental and clinical medicine. 2012;3:13–17.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>19. Dipietro J.A. Maternal stress in pregnancy: considerations for fetal development. J. Adolesc. Health. 2012;51:3–8.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>20. O’Donnell J.K., Jensen B.A., Freeman L., Khalife N., Thomas G.O., Glover V. Maternal prenatal anxiety and down regulation of placental 11β HSD2. Psychoneuroendocrinology. 2012;37 6):818–826.</mixed-citation></ref></ref-list></back></article>
