Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC54910.15690/vramn.v70.i5.1443SCIENTIFIC REPORTSНАУЧНЫЕ СООБЩЕНИЯNatriuretic Peptides: Role in Current CardiologyНатрийуретические пептиды: использование в современной кардиологииBurnashevaG. A.БурнашеваГ. А.
Russian Federation

доктор медицинских наук, профессор кафедры факультетской терапии № 1 лечебного факультета Первого МГМУ им. И.М. Сеченова Адрес: 119991, Москва, ул. Трубецкая, д. 8, с. 2, тел.: +7 (499) 248-53-30

dminap@mail.ruNapalkovD. A.НапалковД. А.
Russian Federation

студентка 6-го курса лечебного факультета Первого МГМУ им. И.М. Сеченова Адрес: 119991, Москва, ул. Трубецкая, д. 8, с. 2, тел.: +7 (499) 248-53-30

Ledebouria@mail.ruSechenov First Moscow State Medical University, Moscow, Russian FederationПервый Московский государственный медицинский университет им. И.М. Сеченова, Москва, Российская Федерация031220157055685720312201503122015Copyright ©; 2015, "Paediatrician" Publishers LLCCopyright ©; 2015, Издательство "Педиатръ"2015"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/549

Natriuretic peptides were discovered in 50–70s of the XX century. BNP was more diagnostically and prognostically significant, as it is secreted directly into the ventricles of the heart. The studies demonstrated a high predictive value of increasing the level of BNP in acute decompensation of heart failure and in patients with chronic heart failure in a study of Val-HeFT. It was demonstrated that monitoring the level of NT-proBNP can be used for the selection of optimal therapy, affect the course and outcome of the disease, and reduce the cost of treatment. The next step in learning BNP was to undertake attempts of their use in the therapy of heart failure. Long-term therapy BNP (drug nesiritide) improved left ventricular remodelling in patients with stable heart failure. Currently the definition of the levels of BNP and NT-proBNP is used for the diagnosis and management of patients with heart failure.

Натрийуретические пептиды были открыты в 50–70-е гг. XX в. Натрийуретический пептид типа В (BNP) оказался наиболее диагностически и прогностически значимым, поскольку он секретируется непосредственно в желудочках сердца и более точно отражает нагрузку на миокард. В ходе различных исследований была продемонстрирована высокая предсказательная значимость повышения содержания BNP при острой декомпенсации сердечной недостаточности, а также у пациентов с хронической сердечной недостаточностью в крупном исследовании Val-HeFT. Показано, что мониторирование уровня мозгового натрийуретического пептида (NT-proBNP) может быть использовано для подбора оптимальных лекарственных комбинаций в каждом отдельном случае и тем самым, поможет повлиять на течение и исход заболевания, а также снизить стоимость лечения. Следующим шагом в изучении BNP стали попытки использования его в лечении сердечной недостаточности. Длительная терапия BNP (препарат несиритид) улучшала ремоделирование левого желудочка у пациентов со стабильной сердечной недостаточностью. В настоящее время определение содержания BNP и NT-proBNP используют для диагностики и ведения пациентов с сердечной недостаточностью.

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