Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC49810.15690/vramn.v70.i4.1416SHORT MESSAGESКРАТКИЕ СООБЩЕНИЯMicroRNAs As An Important Precursors of Diagnostic Obstetric PathologyМикроРНК как важные диагностичеcкие предвестники развития акушерской патологииNizyaevaN. V.НизяеваНаталья Викторовна
Russian Federation

Moscow

кандидат медицинских наук, старший научный сотрудник 2-го патологоанатомического отделения,

117997, Москва, ул. Академика Опарина, д. 4

Niziaeva@gmail.comKanN. E.КанНаталья Енкыновна
Russian Federation

Moscow

доктор медицинских наук, заведующая акушерским обсервационным отделением,

117997, Москва, ул. Академика Опарина, д. 4

N_kan@oparina4.ruTyutyunnikV. L.ТютюнникВиктор Леонидович
Russian Federation

Moscow

доктор медицинских наук, заведующий акушерским физиологическим отделением,

117997, Москва, ул. Академика Опарина, д. 4

V_tioutiounnik@oparina4.ruLomovaN. A.ЛомоваНаталья Анатольевна
Russian Federation

Moscow

кандидат медицинских наук, научный сотрудник акушерского обсервационного отделения,

117997, Москва, ул. Академика Опарина, д. 4

Natasha-lomova@yandex.ruNagovitsynaM. N.НаговицынаМарина Николаевна
Russian Federation

Moscow

младший научный сотрудник 2-го патологоанатомического отделения,

117997, Москва, ул. Академика Опарина, д. 4

moremore84@mail.ruProzorovskayaK. N.ПрозоровскаяКсения Николаевна
Russian Federation

Moscow

врач акушерского обсервационного отделения,

117997, Москва, ул. Академика Опарина, д. 4

ksenyap@inbox.ruShchyogolevA. I.ЩёголевАлександр Иванович
Russian Federation

Moscow

доктор медицинских наук, профессор, заведующий 2-м патологоанатомическим отделением,

117997, Москва, ул. Академика Опарина, д. 4

Ashegolev@oparina4.ruResearch Centre for Obstetrics, Gynaecology and NeonatologyНаучный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова290920157044844922909201529092015Copyright ©; 2015, "Paediatrician" Publishers LLCCopyright ©; 2015, Издательство "Педиатръ"2015"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/498

MicroRNAs (miRs) are the class of short nucleotide sequences (21–27 nucleotides) RNA, non-coding protein synthesis. miRs are known as effective posttranscriptional negative regulators of gene expression with specific binding sites of targeted messenger RNA (mRNA) in the cytoplasm, providing translational repression or degradation of the target miR transcript. In this review we studied the role of miRNAs in the development of a physiological pregnancy and obstetric complications. The placenta is a unique organ which provides modulation of the immune system of the maternal organism during pregnancy including miRs which determine immunological tolerance of the body to the tissues of the fetus. Thus the «placental» miRs in maternal circulation may be the potential biomarker revealed at various obstetric pathology on the early stages before clinical manifestation of the diseases.

МикроРНК (мкНК) — класс коротких нуклеотидных последовательностей (21–27 нуклеотидов) РНК, не участвующих в синтезе белка. мкРНК рассматривают как эффективные посттранскрипционные негативные регуляторы экспрессии генов, связывающи- еся со специфическими участками матричных РНК (мРНК) в цитоплазме, обеспечивающие репрессию трансляции или деградацию транскриптов мишеней мРНК. Показана роль мкРНК в развитии нормальной беременности и ее осложнений, уделено внимание профилям мкРНК на разных сроках физиологической беременности, особенно при иммунологической толерантности организма матери к тканям плода во время беременности. Также отмечены мкРНК, ассоциированные с иммуносупрессией, представлен профиль мкРНК, связанных с преэклампсией. Определение плацентарных мкРНК в материнском кровотоке рекомендовано исполь- зовать в качестве раннего прогностического биомаркера значимой акушерской патологии до наступления клинической манифестации заболевания.

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