Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC44210.15690/vramn.v69.i1-2.934ONCOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ОНКОЛОГИИMOLECULAR BIOLOGICAL CHARACTERISTICS OF CANCERМОЛЕКУЛЯРНО-БИОЛОГИЧЕСКИЕ ХАРАКТЕРИСТИКИ ЗЛОКАЧЕСТВЕННЫХ НОВООБРАЗОВАНИЙKushlinskiiN. E.КушлинскийН. Е.
Russian Federation

доктор медицинских наук, профессор, член-корреспондент РАМН, заведующий лабораторией клинической биохимии РОНЦ им. Н.Н. Блохина Адрес: 115446, Москва, Каширское ш., д. 23А, тел.: (499) 324-11-79

biochimia@mtu-net.ruNemtsovaM. V.НемцоваМ. В.
Russian Federation

Russian Medical Academy of Postgraduate Education, Russian Federation

доктор биологических наук, профессор, профессор кафедры медицинской генетики ГБОУ ДПО «РМАПО» МЗ РФ Адрес: 123995, Москва, ул. Баррикадная, д. 2/1, тел.: (495) 622-96-35

nemtsova_m_v@mail.ruN.N. Blokhin Russian Cancer Research Center, Moscow, Russian FederationРоссийский онкологический научный центр им. Н.Н. Блохина, Москва, Российская ФедерацияРоссийская медицинская академия последипломного образования, Москва, Российская Федерация20082014691-2Вестник Российской академии медицинских наук5152008201520082015Copyright ©; 2015, "Paediatrician" Publishers LLCCopyright ©; 2015, Издательство "Педиатръ"2015"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/442

The review presents the main and additional features that distinguish tumor cells from normal tissue cells. They include sustained proliferative signaling, evasion from growth suppressors, resisting cell death, enabling replicative immortality, angiogenesis induction, and invasion and metastasis activation. Basis for the formation of these features is provided by tumor genome instability. Tumors are complex tissues that consist of different cell types interacting with each other as well as with normal cells. An important characteristic of tumor cells is the ability to interact with the tumor microenvironment and the formation of tumor stroma.

В обзоре представлены основные и дополнительные признаки, отличающие опухолевую клетку от клетки нормальной ткани. Эти признаки включают в себя поддержание постоянной пролиферативной сигнализации, уклонение от действия опухолевых супрессоров, избегание апоптоза, увеличение времени жизни клетки, стимуляцию ангиогенеза, и активацию инвазии и метастазирования. Основу для формирования этих признаков предоставляет нестабильность опухолевого генома. Опухоли — это сложные ткани, которые состоят из различных типов клеток, взаимодействующих как друг с другом, так и с нормальными клетками. Важной характеристикой опухолевой клетки является способность к взаимодействию с клеточным микроокружением и формирование опухолевой стромы.

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