Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC43010.15690/vramn.v69i5-6.1045CARDIOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ КАРДИОЛОГИИTHE ROLE OF ALFA-2-BETA-ADRENORECEPTOR IN DEVELOPMENT OF VENTRICULAR CONDUCTION DISTURBANCEРОЛЬ ГЕНА α2β-АДРЕНОРЕЦЕПТОРА В РАЗВИТИИ НАРУШЕНИЙ ВНУТРИЖЕЛУДОЧКОВОЙ ПРОВОДИМОСТИNikulinaS. Yu.НикулинаС. Ю.
Russian Federation

PhD, professor, Head of the Department of Intestinal Diseases № 1 of V.F.Voino-Yasenetskii Krasnoyarsk State Medical University. Address: 3G, Partizana Zheleznyaka Street, Krasnoyarsk, RF, 660022; tel.: +7 (391) 292-53-79

nicoulina@mail.ruTret'yakovaS. S.ТретьяковаС. С.
Russian Federation

resident physician of the Department of Intestinal Diseases № 1 of V.F.Voino-Yasenetskii Krasnoyarsk State Medical University. Address: 3G, Partizana Zheleznyaka Street, Krasnoyarsk, RF, 660022; tel.: +7 (983) 151-97-89,

tretyakova-svet@mail.ruMaksimovV. N.МаксимовВ. Н.
Russian Federation

Head of the Laboratory of Molecular Genetic Study of Therapeutic diseases of Research Institute of Therapy and Preventive Medicine. Address: 175/1, Borisa Bogatkova Street, Novosibirsk, RF, 630089; tel.: +7 (383) 373-09-81

rootnii@iimed.ruVoevodaM. I.ВоеводаМ. И.
Russian Federation

PhD, professor, correspondent member of RAMS, Director of Research Institute of Therapy and Preventive Medicine. Address: 175/1, Borisa Bogatkova Street, Novosibirsk, RF, 630089; tel.: +7 (383) 373-09-81

voevodami@mail.ruChernovV. N.ЧерновВ. Н.
Russian Federation

MD, assistant of the Department of Dental orthopedics of V.F.Voino-Yasenetskii Krasnoyarsk State Medical University. Address: 3G, Partizana Zheleznyaka Street, Krasnoyarsk, RF, 660022; tel.: +7 (391) 293-27-57,

chernovortstom@mail.ruChernovaA. A.ЧерноваА. А.
Russian Federation

MD, assistant professor of the Department of Intestinal Diseases № 1 of V.F.Voino-Yasenetskii Krasnoyarsk State Medical University. Address: 3G, Partizana Zheleznyaka Street, Krasnoyarsk, RF, 660022; tel.: +7 (391) 241-56-96

anechkachernova@yandex.ruVoino-Yasenetsky Krasnoyarsk State Medical University, Russian FederationКрасноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого, Российская ФедерацияInstitute of Internal Medicine, Novosibirsk, Russian FederationНИИ терапии, Новосибирск, Российская Федерация01102014695-6Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук606407082015Copyright ©; 1970, "Paediatrician" Publishers LLCCopyright ©; 1970, Издательство "Педиатръ"1970"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/430

Background: The purpose of this study was to investigate association between the genetic polymorphism I/D of gene α2β-adrenoreceptor (ADRA2B) and hereditary disorders of ventricular conduction. Patients and methods: In this study, 102 people with complete left bundle branch block (45,71±1,852 years) — 46 females and 56 males, and 86 people with complete right bundle branch block (34,59±1,86 years) — 41 females and 45 males. The study was approved by Ethic Committee of the KrasSMU. All participants were included in the study after written informed consent form. Cardiological examination included clinical examination, electrocardiography, echocardiography, Holter monitoring, stresstest, koronaroangiografy and radionuclide method of a myocardium and molecular and genetic researches. Results: Statistically, significant prevalence of a homozygous genotype of DD on rare allele gene ADRA2B in both groups in comparison with group of control is established. The reliable dominance of the homozygous rare genotypes (D allele) of gene ADRA2B were detected in all groups. Conclusion: Polymorphism DD of a gene ADRA2B is a genetic predictor of predisposition to the blockade of the right and left bundle branch block.

Цель исследования: изучить ассоциацию I/D-полиморфизма гена α2β-адренорецептора (ADRA2B) с первичными нарушениямивнутрижелудочковой проводимости. Пациенты и методы: в исследование были включены лица с наследственными нарушениями внутрижелудочковой проводимости. Обследовано 102 человека с нарушением проводимости по левой ножке пучка Гиса (45,71±1,85 лет; 46 женщин и 56 мужчин) и 86 — с нарушением проводимости по правой ножке пучка Гиса (34,59±1,86 лет; 41 женщина и 45 мужчин). Научное исследование одобрено Этическим комитетом КрасГМУ. Всем обследуемым с нарушениями сердечной проводимости было проведено клинико-инструментальное исследование по следующей программе: клинический осмотр, электро- и эхокардиография, холтеровское мониторирование, велоэргометрия, коронароангиография и сцинтиграфия миокарда, молекулярно-генетические исследования. Результаты: установлено статистически значимое преобладание гомозиготного генотипа DD по редкому аллелю гена ADRA2B в обеих группах по сравнению с группой контроля. Выводы: полиморфизм DD гена ADRA2B является генетическим предиктором предрасположенности к возникновению полной блокады правой и левой ножки пучка Гиса.

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