Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC42210.15690/vramn.v69i5-6.1037РATHOPHYSIOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ПАТОФИЗИОЛОГИИPERSPECTIVE ОF USE ОF AGONISTS OF ADENOSINE AND OPIOID RECEPTORS FOR PREVENTION OF REPERFUSION DAMAGES OF HEART. ANALYSIS OF EXPERIMENTAL AND CLINICAL DATAПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ АГОНИСТОВ АДЕНОЗИНОВЫХ И ОПИОИДНЫХ РЕЦЕПТОРОВ ДЛЯ ПРЕДУПРЕЖДЕНИЯ РЕПЕРФУЗИОННЫХ ПОВРЕЖДЕНИЙ СЕРДЦА. АНАЛИЗ ЭКСПЕРИМЕНТАЛЬНЫХ И КЛИНИЧЕСКИХ ДАННЫХMaslovL. N.МасловД. Н.
Russian Federation

PhD, professor, Head of the Laboratory of Experimental Cardiology of Research Institute of Cardiology

доктор медицинских наук, профессор, руководитель лаборатории экспериментальной кардиологии НИИ кардиологии

Maslov@cardio-tomsk.ruMrochekA. G.МрочекА. Г.
Belarus

PhD, professor, academician of the National Academy of Sciences of Belarus, Director of the Republic Research Centre “Cardiology”

доктор медицинских наук, профессор, академик Национальной академии наук Беларуси, директор Республиканского научно-практического центра «Кардиология»

a.mrochek@mail.byKhaliulinI. G.ХалиулинИ. Г.
United Kingdom

MD, research scientist of the Laboratory of Biochemistry of Bristol University

кандидат медицинских наук, научный сотрудник лаборатории биохимии Университета Бристоля

I.Khaliulin@bristol.ac.ukPortnichenkoA. G.КрылатовА. В.
Ukraine

MD, senior research scientist of the Department of General and Molecular Pathophysiology of A.A. Bogomol'ts Institute of Physiology

кандидат медицинских наук, старший научный сотрудник отдела общей и молекулярной патофизиологии Института физиологии им. А.А. Богомольца

port@serv.biph.kiev.uaChausskayaEvaПортниченкоА. Г.
Israel

MD, research scientist at the Department of Developmental Biology and Cancer Research, Faculty of Medicine of the Hebrew University of Jerusalem

кандидат медицинских наук, научный сотрудник отдела биологии развития и исследования рака факультета медицины Еврейского университета Иерусалима

evchik@inbox.ruKrylatovA. V.ЧаусскаяЕ.
Russian Federation

MD, senior research scientist of the Laboratory of Experimental Cardiology of Research Institute of Cardiology. Address: 111, Kievskaya Street, Tomsk, RF, 634012, tel.: +7 (3822) 26-21-74

Maslov@cardio-tomsk.ruNaryzhnayaN. V.НарыжнаяН. В.
Russian Federation

kandidat meditsinskikh nauk, starshii nauchnyi sotrudnik laboratorii ekspe-rimental’noi kardiologii NII kardiologii Address: 111, Kievskaya Street, Tomsk, RF, 634012, tel.: +7 (3822) 26-21-74

natalynar@yandex.ruGorbunovA. S.ГорбуновА. С.
Russian Federation

kandidat meditsinskikh nauk, mladshii nauchnyi sotrudnik laboratorii eksperimental’noi kardiologii NII kardiologii Address: 111, Kievskaya Street, Tomsk, RF, 634012, tel.: +7 (3822) 26-21-74

barabator@sibmail.comTsibul'nikovS. Yu.ЦибульниковС. Ю.
Russian Federation

kandidat meditsinskikh nauk, mladshii nauchnyi sotrudnik laboratorii eksperimental’noi kardiologii NII kardiologii Address: 111, Kievskaya Street, Tomsk, RF, 634012, tel.: +7 (3822) 26-21-74

seregka2010@hotmail.comResearch Institute for Cardiology, TomskНИИ кардиологии, ТомскRepublic Scientific-Practical Center «Cardiology», MinskРеспубликанский научно-практический центр «Кардиология», МинскUniversity of BristolУниверситет БристоляA.A. Bogomoletz Institute of Physiology, KievИнститут физиологии им. А.А. Богомольца, КиевThe Hebrew University of JerusalemЕврейский университет ИерусалимаResearch Institute for Cardiology, Tomsk, Russian FederationНИИ кардиологии, Томск, Российская Федерация01102014695-6Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук51307082015Copyright ©; 1970, "Paediatrician" Publishers LLCCopyright ©; 1970, Издательство "Педиатръ"1970"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/article/view/422

In Russia inhospital lethality after acute myocardial infarction is 16,5–16,7%. The part of patients perishes even after recanalisation of infarctrelated coronary artery as a result of reperfusion cardiac injury. Experimental data indicate that adenosine receptor agonists and opioids can prevent reperfusion damages of heart that is mimic postconditioning phenomena. Data of clinical observation show that adenosine during intravenous infusion or intracoronary administration during thrombolysis or percutaneous coronary intervention exert infarct reducing effect and eliminate manifestation of «no-reflow» phenomenon. Clinical data indicate that morphine is able to prevent cardiac reperfusion injury in human. Thus, analysis of published data testifies that adenosine and opioid receptor agonists can be prototype for development of drugs for prophylaxis of reperfusion heart injury.

В Российской Федерации внутригоспитальная летальность после острого инфаркта миокарда составляет 16,5–16,7%. Часть пациентов погибают уже после реканализации инфарктсвязанной коронарной артерии в результате реперфузионных повреждений сердца. Экспериментальные данные свидетельствуют, что агонисты аденозиновых рецепторов и опиоиды могут предупреждать реперфузионные повреждения сердца, т.е. имитировать феномен посткондиционирования. Данные клинических наблюдений показывают, что аденозин при внутривенной инфузии, интракоронарном введении при тромболизисе или чрескожном коронарном вмешательстве оказывает инфарктлимитирующий эффект и устраняет проявления феномена «no-reflow». Клинические данные свидетельствуют, что морфин способен предупреждать реперфузионные повреждения сердца у человека. Таким образом, анализ литературных данных говорит о том, что агонисты аденозиновых и опиоидных рецепторов могут стать прототипом для разработки препаратов для профилактики реперфузионных повреждений сердца.

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