Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciences0869-60472414-3545"Paediatrician" Publishers LLC42110.15690/vramn.v69i7-8.1123PROBLEMS OF DEPRESSIVE INSOMNIATarakanovaE. A.<p>PhD, associate professor of the Department of Psychiatry, Addiction and Psychotherapy with a course of psychiatry, addiction psychiatrists of Doctors Improvement Faculty of VolgSMU</p><p> </p>yolka20@yandex.ruIvanchukE. G.virostov11@yandex.ruRostovshchikovV. V.virostov11@yandex.ruVolgograd State Medical UniversityVolgograd State Medical University, Russian Federation20072014697-815315707082015Copyright © 1970, "Paediatrician" Publishers LLC1970<em><strong>Aim:</strong> To evaluate the efficacy and safety of antidepressant agomelatine in relation to the normalization of circadian rhythms in a psychiatric outpatient practice. <strong>Patients and methods</strong>: It was an open label, non-comparative observational study of 32 patients 18–55 years during the eight-week therapy of major depressive episode mild or moderate severity. For statistical analysis the obtained results were used software package Excel 97. <strong>Results:</strong> On the background of treatment marked improvement in levels of depression and decreased intra-group scores of the indicators of the scale of Leeds. A statistically significant increase in the proportion of responders and remitters is achieved already in the first 2 weeks of therapy. <strong>Conclusion:</strong> Thus, in the course of the study, it was shown that along with antidepressant effects, agomelatine able to synchronize disturbed circadian rhythms and to correct sleep disorders in patients with depression.</em><br /><br />depressionsleep disordersantidepressantдепрессиянарушения снаантидепрессант[1.Оруджев Н.Я., Тараканова Е.А. Пограничная психическая патология в общемедицинской практике. Вестн. ВолгГМУ.2008; 2: 3–6.][2.Краснов В.Н. Выявление и лечение депрессий в пер-вичной медицинской сети. Соц. и клин. психиатрия. 1999; 9 (4): 59.][3.Mischoulon D., McColl-Vuolo R., Howarth S., Lagomasino T., Alpert J.E., Nierenberg A.A., Fava M. Management of MD in the primary care setting. Psychother. 2001; 70: 103–107.][4.Смулевич А.Б. Депрессии при соматических и психиче-ских заболеваниях. М.: МИА. 2003. 432 с.][5.Furlanetto L.M., Cavanaugh S., Bueno J.R. Association between depressive symptoms and mortality in medical inpatients. Psychosom. 2000; 41 (5): 426– 432.][6.Клиника, дифференциальная диагностика и лечение депрессивных расстройств: Уч.-метод. пос. Под ред. Н.Я. Оруджева, В.В. Ростовщикова. Волгоград: Вол-гГМУ. 2013. 108 с.][7.Дробижев М.Ю., Макух Е.А. Депрессии у больных, наблюдающихся врачами разных специальностей в общей медицине. Обозрение психиатрии и мед. психол. 2007; 9 (4): 26–29.][8.Johansson C., Willeit M., Smedh C., Ekholm J., Paunio T., Kieseppä T., Lichtermann D., Praschak-Rieder N., Neumeister A., Nilsson L.G., Kasper S., Peltonen L., Adolfsson R., Schalling M., Partonen T. Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference. Neuropsychopharmacol. 2003; 28: 734–739.][9.Клиническое применение психотропных средств: Уч. пос. Под ред. Н.Я. Оруджева, Е.А. Таракановой. Волгоград: ВолгГМУ. 2013. 100 с.][10.Аведисова А.С. Ремиссия: новая цель терапии и новые методы ее оценки. Психиатр. и психофармакотер. 2004; 6 (4): 156–158.]