Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC38410.15690/vramn384CARDIOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ КАРДИОЛОГИИDEPRESSION AND CARDIOVASCULAR DISEASESДЕПРЕССИЯ И СЕРДЕЧНО-СОСУДИСТЫЕ ЗАБОЛЕВАНИЯNuralievaN. F.НуралиеваН. Ф.
Russian Federation

undergraduate of Faculty of general medicine of I.M. Sechenov First Moscow State Medical University Address: bld. 2, 8, Trubetskaya Street, Moscow, 119992, tel.: +7 (495) 609-14-00

студентка 6-го курса лечебного факультета Первого МГМУ им. И.М. Сеченова Адрес: 119992, Москва, ул. Трубецкая, д. 8, стр. 2, тел.: +7 (495) 609-14-00

NNurana@yandex.ruNapalkovD. A.НапалковД. А.
Russian Federation

PhD, professor of the Intermediate Level Therapy Department of №1 of Faculty of general medicine of I.M. Sechenov First Moscow State Medical University, Head of the Therapy School of I.M. Sechenov First MSMU Address: bld. 2, 8, Trubetskaya Street, Moscow, 119992, tel.: +7 (495) 609-14-00

доктор медицинских наук, профессор кафедры факультетской терапии №1 лечебного факультета Первого МГМУ им. И.М. Сеченова, руководитель Школы мастерства по терапии Первого МГМУ им. И.М. Сеченова Адрес: 119992, Москва, ул. Трубецкая, д. 8, стр. 2, тел.: +7 (495) 609-14-00

dminap@mail.ruI.M. Sechenov First Moscow State Medical University, Russian FederationПервый Московский государственный медицинский университет им. И.М. Сеченова, Российская Федерация20102014699-10Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук212607082015Copyright ©; 1970, "Paediatrician" Publishers LLCCopyright ©; 1970, Издательство "Педиатръ"1970"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/384

Depression is considered to be an independent cardiovascular risk factor and it may worsen the symptoms of already established cardiovascular pathology such as coronary heart disease, chronic heart failure, stroke and hypertension. 3 key psychobiological mechanisms by means of which depression influences cardiovascular system: disbalance in stress response of endocrine system, hyperregulation of autonomic nervous system and immune disorders leading to dysregulation of acute phase proteins and proinflammatory cytokines release. In majority of studies in patients with depression and cardiovascular diseases it was shown that antidepressants improve the symptoms. By the way, in some studies controversial results were obtained. Future studies in this direction with involvement of cardiologists and psychiatrists should be held.

Депрессия представляет собой независимый фактор риска развития сердечно-сосудистых заболеваний, а также ухудшает течение уже имеющейся кардиологической патологии: ишемической болезни сердца, хронической сердечной недостаточности, перенесенного инсульта, артериальной гипертензии. Определены три основных психобиологических механизма, посредством которых депрессия влияет на сердечно-сосудистую систему: нарушение стрессового ответа эндокринной системы; гиперрегуляция автономной нервной системы и нарушения в иммунной системе с дисрегуляцией высвобождения белков острой фазы и провоспалительных цитокинов. В большинстве исследований у пациентов с депрессией и сердечно-сосудистыми заболеваниями показано, что лечение антидепрессантами приводит к улучшению симптоматики. В то же время в ряде исследований продемонстрирована обратная закономерность, ввиду чего необходимо дальнейшие проведение исследований в данном направлении с участием клиницистов-кардиологов и психиатров.

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