Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC3510.15690/vramn.v70i3.1326PEDIATRICS: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ПЕДИАТРИИMEDICAL AND SOCIAL PROBLEMS OF ASSISTED REPRODUCTIVE TECHNOLOGIES FROM THE PERSPECTIVE OF PEDIATRICSМЕДИКО-СОЦИАЛЬНЫЕ ПРОБЛЕМЫ ВСПОМОГАТЕЛЬНЫХ РЕПРОДУКТИВНЫХ ТЕХНОЛОГИЙ С ПОЗИЦИИ ПЕДИАТРИИBaranovA. A.БарановА. А.
Russian Federation

доктор медицинских наук, профессор, академик РАН, директор Научного центра здоровья детейАдрес: 119991, Москва, Ломоносовский пр-т, д. 2, стр. 1, тел.: +7 (499) 134-30-83

baranov@nczd.ruNamazova-BaranovaL. S.Намазова-БарановаЛ. С.
Russian Federation

доктор медицинских наук, профессор, член-корреспондент РАН, директор НИИ педиатрии Научного центра здоровья детей, заведующая кафедрой факультетской педиатрии РНИМУ им. Н.И. ПироговаАдрес: 119991, Москва, Ломоносовский пр-т, д. 2, стр. 2, тел.: +7 (495) 967-14-14

namazova@nczd.ruBelyaevaI. A.БеляеваИ. А.
Russian Federation

доктор медицинских наук, заведующая отделением для недоношенных детей НИИ педиатрии Научного центра здоровья детейАдрес: 119991, Москва, Ломоносовский пр-т, д. 2, стр. 1, тел.: +7 (499) 134-15-19

belyaeva@nczd.ruBombardirovaE. P.БомбардироваЕ. П.
Russian Federation

доктор медицинских наук, профессор, главный научный сотрудник отделения для недоношенных детей НИИ педиатрии Научного центра здоровья детейАдрес: 119991, Москва, Ломоносовский пр-т, д. 2, стр. 1, тел.: +7 (499) 134-15-19

namazova@nczd.ruSmirnovE. P.СмирновИ. Е.
Russian Federation

доктор медицинских наук, профессор, главный научный сотрудник лабораторного отдела НИИ педиатрии Научного центра здоровья детейАдрес: 119991, Москва, Ломоносовский пр-т, д. 2, стр. 1, тел.: +7 (499) 134-30-83

smirnov@nczd.ruScientific Center of Children's Health, Moscow, Russian Federation I.M. Sechenov First Moscow State Medical University, Moscow, Russian FederationНаучный центр здоровья детей, Москва, Российская Федерация Первый Московский государственный медицинский университет им. И.М. Сеченова, Российская ФедерацияScientific Center of Children's Health, Moscow, Russian Federation I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation Pirogov Russian National Research Medical University, Moscow, Russian FederationНаучный центр здоровья детей, Москва, Российская Федерация Первый Московский государственный медицинский университет им. И.М. Сеченова, Российская Федерация Российский национальный исследовательский медицинский университет им. Н.И. Пирогова, Москва, Российская ФедерацияScientific Center of Children's Health, Moscow, Russian FederationНаучный центр здоровья детей, Москва, Российская Федерация10062015703Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук07082015Copyright ©; 2015, "Paediatrician" Publishers LLCCopyright ©; 2015, Издательство "Педиатръ"2015"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/35

The article presents a literature review over the last few years devoted to the health status and development peculiarities of children born using assisted reproductive technologies (ART) procedures. The statistics shows an explosive increase in the frequency of ART application as a fertility treatment method. The presented data analysis reflects the perinatal outcomes after ART in children, the frequency of congenital malformations and genetic diseases in this population, possible long-term malconditions and pathologies in children born using ART. The overwhelming majority of investigators consider the adverse effect of ART on a child’s body to be the result of prematurity and multiple pregnancy (transfer multiple embryos followed by partial reduction). It is stated that the widespread introduction of ART may contribute to the vertical transmission of parental infertility factors in the population. The application of ART procedures in some cases is associated with controversial ethical and legal issues (surrogacy, oocyte donation). Further improvements in ART procedures (preimplantation training, medical and genetic diagnosis, reducing the frequency of multiple pregnancy) cannot be stated as an alternative to the general medical and social prevention of reproductive disorders in adolescents and youth.

В статье представлен анализ данных литературы последних лет, посвященной особенностям состояния здоровья и развития детей, родившихся с помощью вспомогательных репродуктивных технологий (ВРТ). Данные статистики свидетельствуют о лавинообразном увеличении частоты применения ВРТ как метода лечения бесплодия. В обзоре литературы отражены исходы перинатального периода у детей после ВРТ, частота врожденных пороков развития и генетических заболеваний в этой популяции, возможные отдаленные патологические состояния у детей, родившихся с помощью ВРТ. Подавляющее большинство исследователей связывают неблагоприятные влияния ВРТ на организм ребенка с недоношенностью и многоплодием (трансфер нескольких эмбрионов с последующей частичной редукцией). Указывается, что широкое внедрение ВРТ может способствовать вертикальной передаче факторов родительского бесплодия в популяции. Применение ВРТ в некоторых случаях сопряжено со спорными этическими и правовыми проблемами (суррогатное материнство, донорство ооцитов). Дальнейшее совершенствование технологий ВРТ (предимплантационная подготовка, медико-генетическая диагностика, сокращение частоты многоплодий) не является альтернативой для широкой медико-социальной профилактики нарушений в репродуктивной сфере у подростков и молодежи.

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