Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC32810.15690/vramn.v67i3.181ONCOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ОНКОЛОГИИNANOSTRUCTURED LIPOSOMAL SYSTEMS AS TRANSPORT AGENTS FOR ANTICANCER DRUGSНАНОСТРУКТУРИРОВАННЫЕ ЛИПОСОМАЛЬНЫЕ СИСТЕМЫ КАК СРЕДСТВО ДОСТАВКИ ПРОТИВООПУХОЛЕВЫХ ПРЕПАРАТОВBaryshnikovA. Yu.БарышниковА. Ю.
Russian Federation

доктор медицинских наук, профессор, зам. директора РОНЦ им. Н.Н. Блохина РАМН по научной части, директор НИИ ЭДиТО РОНЦ им. Н.Н. Блохина РАМН Адрес: 115448, Москва, Каширское шоссе, д. 24 Тел.: (499) 324-22-74

baryshnikov_anat@mail.ruFSBI Blokhin Russian oncological scientific centre RAMS, MoscowФГБУ «Российский онкологический научный центр имени Н.Н. Блохина» РАМН, Москва23032012673Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук233107082015Copyright ©; 2012, "Paediatrician" Publishers LLCCopyright ©; 2012, Издательство "Педиатръ"2012"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/328

Liposomes quite recently have turned from a model of biological membranes into an object of extensive research and practical use. The versatile traits of liposomal formulation allow its' universal implementation, especially in cancer chemotherapy. The advantages of liposomal use as a carrier of an anticancer drug for its targeted selective accumulation are discussed in this article. This article contains description of new types of liposomes, differing in contents and use, such as: simple, sterically stabilized, targeted (immunoliposomes),cationic, sensitive to physical and chemical stimuli. The characteristics of liposomal systems of anticancer drug delivery designed at Blokhin Russian Oncological Scientific Centre is given in the article.

За сравнительно короткий срок липосомы превратились из простой модели, имитирующей клеточные мембраны, в объект активных научных исследований и практического применения. Универсальные свойства липосомальной лекарственной формы объясняют широкие возможности ее применения, особенно в химиотерапии рака. В обзоре рассматриваются преимущества использования липосом в качестве носителей лекарственных препаратов для селективного накопления действующих веществ в патологических очагах. Приводится описание основных типов липосом, отличающихся составом и применением in vivo: простые, стерически стабилизированные, направленные (иммунолипосомы), катионные, липосомы, чувствительные к физическим и химическим стимулам. Представлена характеристика липосомальных систем доставки противоопухолевых препаратов, разработанных в РОНЦ им. Н.Н. Блохина РАМН.

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