Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC32410.15690/vramn.v67i4.203ENDOCRINOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ЭНДОКРИНОЛОГИИNOVEL CONCEPTS IN BIOLOGY OF DIFFUSE ENDOCRINE SYSTEM: RESULTS AND FUTURE INVESTIGATIONSНОВЫЕ КОНЦЕПЦИИ БИОЛОГИИ ДИФФУЗНОЙ ЭНДОКРИННОЙ СИСТЕМЫ: ИТОГИ И ПЕРСПЕКТИВЫ ЕЕ ИЗУЧЕНИЯYaglovV. V.ЯгловВ. В.
Russian Federation

доктор медицинских наук, профессор, заведующий лабораторией развития эндо- кринной системы НИИ морфологии человека РАМН Адрес: 117418, Москва, ул. Цюрупы, д. 3 Тел./факс: (499) 120-80-65

yaglova@mail.ruYaglovaV. N.ЯгловаН. В.
Russian Federation

кандидат медицинских наук, старший научный сотрудник лаборатории развития эндокринной системы НИИ морфологии человека РАМН Адрес: 117418, Москва, ул. Цюрупы, д. 3 Тел.: (499) 120-80-65

yaglova@mail.ruResearch Institute of Human Morphology of Russian Academy of Medical Sciences, MoscowФГБУ «Научно-исследовательский институт морфологии человека» РАМН23042012674Vestnik Rossiiskoi akademii medetsinskikh nauk / Annals of the Russian academy of medical sciencesВестник Российской академии медицинских наук748107082015Copyright ©; 2012, "Paediatrician" Publishers LLCCopyright ©; 2012, Издательство "Педиатръ"2012"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/324

Diffuse endocrine system is a largest part of endocrine system of vertebrates. Recend findings showed that DES-cells are not neuroectodermal but have ectodermal, mesodermal, and entodermal ontogeny. The article reviews novel concept of diffuse endocrine system anatomy and physiology, functional role of DES hormones and poorly investigated aspects like DES-cell morphology, hormones secretion in normal and pathologic conditions. Further research of diffuse endocrine system has a great significance for biochemistry, morphology, and clinical medicine.

Диффузная эндокринная система — крупнейшее звено эндокринной системы позвоночных животных. В последние годы появились убедительные данные в пользу того, что клетки диффузной эндокринной системы имеют не нейроэктодермальное происхождение, а развиваются из экто-, мезо- и энтодермы. Рассмотрена современная концепция ее структурно-функциональной организации, значение в регуляции функций организма и нерешенные проблемы ее биологии, к которым относится не только гистогенез клеток, но и строение диффузной эндокринной системы, функциональное значение продуцируемых гормонов, а также процессы секреции гормонов в норме и при различных патологиях, что имеет большое научно-практическое значение как для биохимии и морфологии, так и для многих клинических дисциплин.

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