Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC30710.15690/vramn.v67i5.277SHORT MESSAGESКРАТКИЕ СООБЩЕНИЯGNOTOBIOLOGY IN MODERN BIO-MEDICAL RESEARCHГНОТОБИОЛОГИЯ В СОВРЕМЕННЫХ МЕДИКО-БИОЛОГИЧЕСКИХ ИССЛЕДОВАНИЯХPodoprigoraG. I.ПодопригораГ. И.
Russian Federation

доктор медицинских наук, профессор, директор НИИ цитохимии и молеку- лярной фармакологии Адрес: 115404, Москва, ул. 6-я Радиальная, д. 24, стр. 14 Тел./факс: (495) 327-49-87

gipodoprigora@yandex.ruKafarskayaL. I.КафарскаяЛ. И.
Russian Federation

доктор медицинских наук, профессор, заведующая кафедрой микробиологии и вирусологии РНИМУ им. Н.А. Пирогова Адрес: 117869, Москва, ул. Островитянова, д. 1 Тел.: (495) 434-17-66

likmed@mail.ruBainovN. A.БайновН. А.
Russian Federation

кандидат медицинских наук, доцент кафедры микробиологии и вирусологии РНИМУ им. Н.А. Пирогова Адрес: 117869, Москва, ул. Островитянова, д. 1 Тел.: (495) 434-17-66

vonib@mail.ruThe Russian National Research Medical University named after N.I. Pirogov (RNRMU), Moscow Research Institute of Cytochemistry and Molecular Pharmacology, MoscowФГБУ Российский национальный исследовательский медицинский университет им. Н.И. Пирогова Минздравсоцразвития России, Москва Некоммерческое учреждение Научно-исследовательский институт цитохимии и молекулярной фармакологии, МоскваThe Russian National Research Medical University named after N.I. Pirogov (RNRMU), MoscowФГБУ Российский национальный исследовательский медицинский университет им. Н.И. Пирогова Минздравсоцразвития России, Москва23052012675Вестник Российской академии медицинских наук637007082015Copyright ©; 2012, "Paediatrician" Publishers LLCCopyright ©; 2012, Издательство "Педиатръ"2012"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/307

An overview of the present status and prospects of gnotobiology along with a role of normal microflora studied using laboratory animals with controlled microflora (gnotobiotes) is presented. The principal elements of gnotobiotechnology as well as possibilities of its using in both experimental and clinical investigations are analyzed. A multifaceted role of normal microflora in the host physiology and pathology prejudge the increasing importance of gnotiological models in various fields of biology and medicine, such as the development of new generations probiotics. An assessment and characteristics of selected microbial strains, host-microbe interactions etc. An organization of further complex gnotobiotic research is of prospective value.

В обзоре освещено современное состояние и перспективы гнотобиологии и исследований роли нормальной микрофлоры на основе экспериментов с лабораторными животными с контролируемой микрофлорой (гнотобиотами). Рассмотрены основные элементы гнотобиологической технологии и возможности ее использования в экспериментальных и клинических исследованиях. Показана многогранная роль нормальной микрофлоры в физиологических реакциях и при патологии макроорганизма, предопределяющая значение гнотобиологических моделей в различных областях медицины и биологии, в частности, при разработке и изучении пробиотиков нового поколения, при оценке и характеристике выделенных штаммов и при изучении их взаимодействия с другими представителями микробиоты. Перспективна организация комплексных гнотобиологических исследований.

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