<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Annals of the Russian academy of medical sciences</journal-id><journal-title-group><journal-title xml:lang="en">Annals of the Russian academy of medical sciences</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российской академии медицинских наук</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0869-6047</issn><issn publication-format="electronic">2414-3545</issn><publisher><publisher-name xml:lang="en">"Paediatrician" Publishers LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">266</article-id><article-id pub-id-type="doi">10.15690/vramn.v67i9.405</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>PROCEEDINGS OF THE RAMS SESSION</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>МАТЕРИАЛЫ СЕССИИ РАМН</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">THE FUNDAMENTS OF NEURONAL PLASTICITY</article-title><trans-title-group xml:lang="ru"><trans-title>ФУНДАМЕНТАЛЬНЫЕ ОСНОВЫ ПЛАСТИЧНОСТИ НЕРВНОЙ СИСТЕМЫ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Skrebitskii</surname><given-names>V. G.</given-names></name><name xml:lang="ru"><surname>Скребицкий</surname><given-names>В. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>доктор биологических наук, профессор, член-корр. РАН и РАМН, заведующий лабораторией функциональной синаптологии отдела исследований мозга ФГБУ «НЦН» РАМН Адрес: 125319, Москва, ул. Черняховского, д. 4/7 Тел./факс: (495) 917-23-82</p></bio><email>skrebitsky@yahoo.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shtark</surname><given-names>M. B.</given-names></name><name xml:lang="ru"><surname>Штарк</surname><given-names>М. Б.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>доктор биологических наук , профессор, академик РАМН, руководитель отдела физики и биоинженерии Института молекулярной биологии и биофизики Адрес: 630117, Новосибирск, ул. Тимакова, д. 2 Тел./факс: (383)335-98-47</p></bio><email>mark@soramn.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Research Center of Neurology Russian Academy of medical Science, Moscow&#13;
Institute of Molecular Biology and Biophysics Siberian Division of RAMS, Novosibirsk</institution></aff><aff><institution xml:lang="ru">Научный центр неврологии РАМН, отдел исследований мозга, Москва&#13;
Институт молекулярной биологии и биофизики СО РАМН, Новосибирск</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2012-09-10" publication-format="electronic"><day>10</day><month>09</month><year>2012</year></pub-date><volume>67</volume><issue>9</issue><issue-title xml:lang="ru">Вестник Российской академии медицинских наук</issue-title><fpage>39</fpage><lpage>44</lpage><history><date date-type="received" iso-8601-date="2015-08-07"><day>07</day><month>08</month><year>2015</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2012, "Paediatrician" Publishers LLC</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2012, Издательство "Педиатръ"</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="en">"Paediatrician" Publishers LLC</copyright-holder><copyright-holder xml:lang="ru">Издательство "Педиатръ"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://vestnikramn.spr-journal.ru/jour/article/view/266">https://vestnikramn.spr-journal.ru/jour/article/view/266</self-uri><abstract xml:lang="en"><p> <italic>Plasticity of the nervous system is determined by the modification of efficacy of synaptic transmission: long- term potentiation and long- term depression. Different modern technical approaches such as: registration of ionic currents in single neuron, molecular- genetic analysis, neurovisualization, and others reveal the molecular mechanisms of synaptic plasticity. The understanding of these mechanisms, in its turn, stimulates the development of methods of pharmacological correction of different forms of brain pathology such as Alzheimer disease, parkinsonism, alcoholism, aging and others. </italic></p><p> </p></abstract><trans-abstract xml:lang="ru"><p><italic>Основой пластичности нервной системы является модификация эффективности синаптической передачи: длительная потенциация или депрессия. Применение современных технологий: регистрация ионных токов отдельных клеток, молекулярно-генетический анализ нейровизуализация, компьютерное моделирование и другие методы раскрывают молекулярные механизмы, лежащие в основе синаптической пластичности, что, в свою очередь, открывает перспективы фармакологической коррекции и генной терапии неврологическиих расстройств, связанных с болезнью Альцгеймера, алкоголизмом, гипоксией, старением и различными формами нарушения обучения и памяти.</italic></p><p> </p></trans-abstract><kwd-group xml:lang="en"><kwd>Synaptic plasticity</kwd><kwd>hippocamp</kwd><kwd>long term potentiation</kwd><kwd>early genes</kwd><kwd>protein S-100B</kwd><kwd>Alzheimar’s disease</kwd><kwd>alcoholism</kwd><kwd>donepezil</kwd><kwd>noopept</kwd><kwd>patch- clamp method</kwd><kwd>ionic currents</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>синаптическая пластичность</kwd><kwd>гиппокамп</kwd><kwd>болезнь Альцгеймера</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>1.	Kandel E.R., Schwartz J.H. and Jessell T.M. Principles of Neuronal Science. 2000, McGrow-Hill.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>2.	Bliss T.V. P., Lomo T. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol. 1973; 232: 331–336.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>3.	Skrebitskii V.G. Neuroregulators influence on hippocampal synaptic activity. Uspekhi fiziologichekikh nauk = Achievements of physiological sciences. 1985; 4: 35-48.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>4.	Sokolova O.O., Shtark M.B., Lisachev P.D., Pustyl'nyak V.O., Epshtein O.I. Dynamics of early gene expression in long-term post-tetanic potentiation in the CA1 region of the hippocampus of rats. Byul. Eksp. Biol i med. = Bulletin of experimental biology and medicine. 2009; 147: 227–229.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>5.	Bramham C.R., Wells D.C. Dendritic mRNA: transport and function. Nature Publishing Group. 2007; 8: 776–789.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>6.	Lisachev P.D., Shtark М.B., Sokolova O.O., Pustylnyak V.O., Salakhutdinova M.Yu. and Epstein O.I.A Comparison of the Dynamics of S100B, S100A1, and S100A6 mRNA Expression in Hippocampal CA1 Area of Rats during Long-TermPotentiation and after Low-Frequency Stimulation. Cardiovascular Psychiatry and Neurology. 2010; Article ID 720958: 1–6.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>7.	Kapai N.A., Bukanova Yu. V.Solntseva E.I., Skrebitsky V.G. Donepezil in a narrow concentration range augments control and impaired by beta-amiloid peptide hippocampal LTP in NMDA- independent manner. Cell. Molec. Neurobiol. 2012; 32: 219–226.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>8.	Gudasheva T.A., Ostrovskaya R.U., Trofimov S.S. et al. Peptide analogs of piracetam suspected nootropic ligands as receptors. Khim. Farm. Zhurn. = Chemical and pharmaceutical journal. 1985; 11: 1322–1328.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>9.	Kapai N.A, Chepkova A.N., GudashevaT.A. et al. Piroglyutamilasparagina amide normalizes development long-term potentiation in rat hippocampal slices. Byul. Eksp. Biol i med. = Bulletin of experimental biology and medicine. 2004; 8: 176–179.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>10.	Kondratenko R.V., Derevyagin V.I., Skrebitsky V.G., Novel nootropic dipeptide Noopept increases inhibitory synaptic transmission in CA1 pyramidal cells. Neuroscience Letters. 2010; 476: 70–73.</mixed-citation></ref></ref-list></back></article>
