Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC24810.15690/vramn.v67i11.473SHORT MESSAGESКРАТКИЕ СООБЩЕНИЯTHE ROLE OF INTERLEUKIN-1 AND ASSOCIATED CYTOKINES IN GASTRIC CARCINOGENESISРОЛЬ ЦИТОКИНОВ СЕМЕЙСТВА ИНТЕРЛЕЙКИНА-1 В ЖЕЛУДОЧНОМ КАНЦЕРОГЕНЕЗЕMatveevaL. V.МатвееваЛ. В.
Russian Federation

кандидат медицинских наук, доцент кафедры иммунологии, микробиологии и виру- сологии медицинского института МГУ им. Н.П. Огарева Адрес: 430032, Республика Мордовия, г. Саранск, ул. Ульянова, д. 26а Тел.: (8342) 35-25-16

MatveevaLjubov1@mail.ruMosinaL. M.МосинаЛ. М.
Russian Federation

доктор медицинских наук, профессор кафедры госпитальной терапии медицинского института МГУ им. Н.П. Огарева Адрес: 430032, Республика Мордовия, Саранск, ул. Ульянова, д. 26а Тел.: (8342) 32-19-83

lardoc@rambler.ruMedical Institute of N.P. Ogarev Mordovian State University, Saransk, Russian FederationМедицинский институт Мордовского государственного университета им. Н.П. Огарева, Саранск, Российская Федерация101120126711Вестник Российской академии медицинских наук596507082015Copyright ©; 2012, "Paediatrician" Publishers LLCCopyright ©; 2012, Издательство "Педиатръ"2012"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/article/view/248

This review presents detailed analysis of scientific data on influence of the associated with interleukin-1 cytokines on the development of malignant tumors of stomach with the definition of spectrum of diagnostic and therapeutic possibilities. Cytokines associated with interleukin-1 directly and indirectly involved into gastric carcinogenesis. Implementation of pro- and contreoncogenic effects depends on many factors. The serological and genetic criteria changes of interleukin-1 have high diagnostic value and prognostic significance opening new differential approaches to the treatment of precancer conditions and gastric cancer.

Целью работы был углубленный анализ научных данных о влиянии цитокинов семейства интерлейкина-1 на развитие злокачественных опухолей желудка с определением спектра диагностических и терапевтических возможностей. Цитокины семейства интерлейкина-1 прямо и опосредованно участвуют в желудочном канцерогенезе. Реализация их про- и антионкогенных эффектов определяется многими факторами. Серологические и генетические критерии изменений содержания интерлейкина-1 обладают высокой диагностической ценностью, прогностической значимостью, открывают новые дифференциальные подходы к терапии предопухолевых заболеваний и рака желудка.

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