Annals of the Russian academy of medical sciencesAnnals of the Russian academy of medical sciencesВестник Российской академии медицинских наук0869-60472414-3545"Paediatrician" Publishers LLC24610.15690/vramn.v67i11.471PHTHISIOLOGY: CURRENT ISSUESАКТУАЛЬНЫЕ ВОПРОСЫ ФТИЗИАТРИИPREVENTION OF TUBERCULOSIS: CURRENT APPROACHES TO DEVELOPMENT OF VACCINESПРОФИЛАКТИКА ТУБЕРКУЛЕЗА: СОВРЕМЕННЫЕ ПОДХОДЫ К РАЗРАБОТКЕ ПРОТИВОТУБЕРКУЛЕЗНЫХ ВАКЦИНStukovaM. A.СтуковаМ. А.
Russian Federation

кандидат медицинских наук, ведущий научный сотрудник лаборатории молеку- лярной вирусологии и генной инженерии ФГБУ «Научно-исследовательский институт гриппа» МЗ РФ Адрес: 197376, Санкт-Петербург, ул. Проф. Попова, д. 15/17 Тел.: (812) 499-15-20

stukova@influenza.spb.ruZabolotnykhN. V.ЗаболотныхН. В.
Russian Federation

доктор медицинских наук, ведущий научный сотрудник лаборатории экспери- ментального туберкулеза и новых медицинских технологий ФГБУ «Санкт-Петербургский научно-исследовательский институт фтизиопульмонологии» МЗ РФ Адрес: 191036, Санкт-Петербург, Лиговский пр-т, д. 2-4 Тел.: (812) 297-86-31

zabol-natal@yandex.ruVinogradovaT. I.ВиноградоваТ. И.
Russian Federation

доктор медицинских наук, профессор, ученый секретарь ФГБУ «Санкт- Петербургский научно-исследовательский институт фтизиопульмонологии» МЗ РФ Адрес: 191036, Санкт-Петербург, Лиговский пр-т, д. 2-4 Тел.: (812) 579-25-84

vinogradova@spbniif.ruGergertV. Ya.ГергертВ. Я.
Russian Federation

доктор медицинских наук, профессор, руководитель отдела иммунологии ФГБУ «Центральный научно-исследовательский институт туберкулеза» РАМН Адрес: 107564, Москва, ул. Яузская аллея, д. 2 Тел.: (499) 785-90-72

hergert@mail.ruAptA. S.АптА. С.
Russian Federation

доктор биологических наук, профессор, заведующий лабораторией иммуногенетики ФГБУ «Центральный научно-исследовательский институт туберкулеза» РАМН Адрес: 107564, Москва, ул. Яузская аллея, д. 2 Тел.: (499) 785-90-72

stukova@influenza.spb.ruErokhinV. V.КапрелянцА. С.
Russian Federation

доктор биологических наук, профессор, заведующий лабораторией стрессов микроорганизмов ФГБУ «Научно-исследовательский институт биохимии им. А.Н. Баха» РАН Адрес: 125284, Москва, Ленинский пр-т, д. 33 Тел.: (495) 954-40-47

inbi@inbi.ras.ruKaprelyantsA. S.ЕрохинВ. В.
Russian Federation

доктор медицинских наук, профессор, член-корреспондент РАМН, директор ФГБУ «Центральный научно-исследовательский институт туберкулеза» РАМН Адрес: 107564, Москва, ул. Яузская аллея, д. 2 Тел.: (499) 785-91-36

cniit@ramn.ruYablonskiiP. K.ЯблонскийП. К.
Russian Federation

доктор медицинских наук, профессор, директор ФГБУ «Санкт-Петербургский научно-исследовательский институт фтизиопульмонологии» МЗ РФ, профессор медицинского факультета ФГБО ВПО «Санкт-Петербургский государственный университет» Адрес: 191036, Санкт-Петербург, Лиговский пр-т, д. 2-4 Тел.: (812) 579-25-54

spbniif_all@mail.ruKiselevO. I.КиселевО. И.
Russian Federation

академик РАМН, профессор, директор ФГБУ «Научно-исследовательский институт гриппа» МЗ РФ Адрес: 197376, Санкт-Петербург, ул. Проф. Попова, д. 15/17 Тел.: (812) 234-60-00

office@influenza.spb.ruResearch Institute of Influenza, Ministry of Health and Social Development, Saint Petersburg, Russian FederationНаучно-исследовательский институт гриппа МЗ РФ, Санкт-Петербург, Российская ФедерацияSaint-Petersburg Research Institute of Phthisiopulmonology, Ministry of Health and Social Development Saint Petersburg, Russian FederationСанкт-Петербургский научно-исследовательский институт фтизиопульмонологии МЗ РФ, Российская ФедерацияCentral Institute for Tuberculosis, Russian Academy of Medical Science, Moscow, Russian FederationЦентральный научно-исследовательский институт туберкулеза РАМН, Москва, Российская ФедерацияA.N. Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russian FederationНаучно-исследовательский институт биохимии им. Баха РАН, Москва, Российская ФедерацияSaint-Petersburg Research Institute of Phthisiopulmonology, Ministry of Health and Social Development Saint Petersburg, Russian Federation Saint Petersburg State University, Russian FederationСанкт-Петербургский научно-исследовательский институт фтизиопульмонологии МЗ РФ, Российская Федерация Санкт-Петербургский государственный университет, Российская Федерация101120126711Вестник Российской академии медицинских наук455207082015Copyright ©; 2012, "Paediatrician" Publishers LLCCopyright ©; 2012, Издательство "Педиатръ"2012"Paediatrician" Publishers LLCИздательство "Педиатръ"https://vestnikramn.spr-journal.ru/jour/about/submissionshttps://vestnikramn.spr-journal.ru/jour/article/view/246

This review is focused on recent advances in development of new vaccines for the prevention of tuberculosis. The main reasons for lack of BCG vaccine efficacy in different populations and geographic regions are presented. Design of new vaccines based on live modified strains of Mycobacterium bovis BCG, attenuated strains of Mycobacterium tuberculosis, recombinant proteins and viral vectors is considered in the specific examples. The usage of the heterologous «prime-boost» vaccination strategy against tuberculosis is discussed.

В обзоре освещены современные достижения в области разработки новых вакцин для профилактики туберкулеза. Представлены основные причины недостаточной эффективности вакцины БЦЖ в различных популяциях и географических регионах. На конкретных примерах рассмотрены направления дизайна новых вакцин на основе живых модифицированных штаммов Mycobacterium bovis БЦЖ, аттенуированных штаммов Mycobacterium tuberculosis, рекомбинантных белков и вирусных векторов. Обсуждается перспектива применения схемы гетерологичной «prime-boost» вакцинации против туберкулеза.

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